The Renin Angiotensin System, Molecular, Geroscience and Aging-Related Disorders 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 9677
Special Issue Editor
Interests: cardiovascular signaling; angiotensin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous special issue "The Renin Angiotensin System, Molecular, Geroscience and Aging-Related Disorders".
The renin angiotensin system (RAS) plays a key role in blood pressure regulation by controlling vascular smooth muscle constriction and renal water/sodium reabsorption. Disruption of RAS regulation occurs in individuals with cardiovascular disease (CVD) risk factors, leading to hypertension and associated complications. Aging is one of the major nonmodifiable risk factors for hypertension and other CVDs, which is exemplified in middle age individuals whose vasculature is more prematurely aged than that of their chronologically aged counterparts, and who therefore suffer from CVD development sooner. Recent research suggests that over-reactivity of the RAS plays a critical role in the pathogenesis of an accelerated aging phenotype seen in various diseases, such as neurodegenerative, cardiovascular, and metabolic disorders. While the exact mechanism by which RAS contributes to the development of these pathologies is not clear, it likely involves induction of premature senescence and senescence associated secretory phenotype (SASP). Disruption of organelle (i.e., mitochondria) quality control and proteostasis may also be affected in senescence-associated diseases, as these decline with age. Therefore, elucidating the molecular mechanism of the premature aging phenotype induced by the RAS would likely provide potential new therapeutic opportunities to maintain healthy aging and reduce the economic burden of aging diseases in the next century. Accordingly, the topics of this Special Issue include but are not limited to the recent findings in molecular mechanisms of the RAS in cellular aging, how the RAS influences age-related cardiovascular, metabolic, and neurological disorders, and translational evaluations on the findings.
Prof. Satoru Eguchi
Guest Editor
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Keywords
- Senescence
- Biological aging
- Early vascular aging (EVA)
- Aortic stiffness
- Senolytics
- Longevity
- Mitochondria
- Proteotoxicity
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