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Advances in the Molecular Biology of Lung Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 2153

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Guest Editor
Respiratory Diseases and Lung Transplantation Unit, Department of Medicine, Surgery and Neurosciences, University Hospital of Siena, 53100 Siena, Italy
Interests: interstitial lung disease; KL-6; lung transplant; vasculitis; myositis
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Special Issue Information

Dear Colleagues,

A novel era in respiratory medicine is approaching. New innovative scientific techniques, including omics sciences, as well as the analysis and interpretation of Big Data through the implementation of artificial intelligence and bioinformatic algorithms, have already demonstrated tremendous and unseen perspectives for the comprehension of the pathobiology of many respiratory disorders.

This Special Issue of IJMS represents a call for articles that provide new insights into the molecular aspects of the physiology and biochemistry of respiratory diseases. Submissions with an emphasis on emerging approaches, such as omics sciences (genomics, metabolomics, proteomics, lipidomics and glycomics) and cytofluorimetric assays, are welcome. The molecular and immunological bases of diseases are often poorly understood, and so are the effects of aging, gender, smoking, pollution and pharmaceutical intervention.

This Special Issue aims to expand the current comprehension of the molecular pathogenesis of lung diseases and the biomolecular effects of the newest currently approved therapeutical approaches. Experimental studies, including in vitro and in vivo models, review articles and clinical studies, are all eligible for consideration.

Dr. Paolo Cameli
Guest Editor

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Keywords

  • severe asthma
  • COPD
  • lung cancer
  • pathology
  • molecular biomarkers
  • interstitial lung diseases
  • immunobiology
  • omics
  • prognosis
  • pathogenesis
  • proteomics
  • genetics

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Published Papers (1 paper)

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Research

12 pages, 1177 KiB  
Article
Baricitinib and Pulse Steroids Combination Treatment in Hyperinflammatory COVID-19: A Rheumatological Approach in the Intensive Care Unit
by Francesco Ferro, Gaetano La Rocca, Elena Elefante, Nazzareno Italiano, Michele Moretti, Rosaria Talarico, Erika Pelati, Katia Valentini, Chiara Baldini, Roberto Mozzo, Luigi De Simone and Marta Mosca
Int. J. Mol. Sci. 2024, 25(13), 7273; https://doi.org/10.3390/ijms25137273 - 2 Jul 2024
Cited by 1 | Viewed by 1270
Abstract
Hyperinflammatory Coronavirus disease 2019 (COVID-19) and rapidly-progressive interstitial lung diseases (RP-ILD) secondary to inflammatory myopathies (IIM) present important similarities. These data support the use of anti-rheumatic drugs for the treatment of COVID-19. The aim of this study was to compare the efficacy of [...] Read more.
Hyperinflammatory Coronavirus disease 2019 (COVID-19) and rapidly-progressive interstitial lung diseases (RP-ILD) secondary to inflammatory myopathies (IIM) present important similarities. These data support the use of anti-rheumatic drugs for the treatment of COVID-19. The aim of this study was to compare the efficacy of combining baricitinib and pulse steroids with the Standard of Care (SoC) for the treatment of critically ill COVID-19 patients. We retrospectively enrolled consecutive patients admitted to the Intensive Care Unit (ICU) with COVID-19-pneumonia. Patients treated with SoC (dexamethasone plus remdesivir) were compared to patients treated with baricitinib plus 6-methylprednisolone pulses (Rheuma-group). We enrolled 246 patients: 104/246 in the SoC and 142/246 in the Rheuma-group. All patients presented laboratory findings suggestive of hyperinflammatory response. Sixty-four patients (26.1%) died during ICU hospitalization. The mortality rate in the Rheuma-group was significantly lower than in the SoC-group (15.5 vs. 40.4%, p < 0.001). Compared to the SoC-group, patients in the Rheuma-group presented significantly lower inflammatory biomarker levels after one week of treatment. Higher ferritin levels after one week of treatment were strongly associated with mortality (p < 0.001). In this large real-life COVID-19 cohort, baricitinib and pulse steroids led to a significant reduction in mortality, paralleled by a prompt reduction in inflammatory biomarkers. Our experience supports the similarities between hyperinflammatory COVID-19 and the IIM-associated RP-ILD. Full article
(This article belongs to the Special Issue Advances in the Molecular Biology of Lung Disease 2.0)
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