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Molecular Diagnostics and Treatment Advances in Lung Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 584

Special Issue Editor


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Guest Editor
Department of Respiratory Medicine and Laboratory of Molecular and Cellular Pneumonology, School of Medicine, University of Crete, 71500 Heraklion, Greece
Interests: interstitial lung diseases; idiopathic pulmonary fibrosis; rare lung diseases; bronchoalveolar lavage; systemic autoimmune rheumatic diseases

Special Issue Information

Dear Colleagues,  

I would like to invite you to participate in this Special Issue focused on the advancements in molecular diagnostics and treatment options for lung diseases. As our understanding of these conditions evolves, the need for innovative approaches to diagnosis and therapy is crucial. The investigation of molecular biomarkers might promote the early diagnosis of lung diseases, while deeper research on pathogenetic mechanisms will explore potential targeted therapies, hopefully leading to the enhancement of patient care through personalized medicine approaches.

We encourage the submission of research articles about the development of novel molecular diagnostic tools and treatment strategies that may significantly improve the patients’ outcomes and quality of life. Review articles on this topic are welcome as well. Both obstructive pulmonary diseases (COPD, asthma, bronchiectasis) and rare and interstitial lung diseases (ILDs) may be included. 

We look forward to receiving your contributions.

Dr. Eirini Vasarmidi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung diseases
  • pulmonary
  • alveolar
  • diagnosis
  • treatment
  • biomarkers
  • molecular
  • bronchoalveolar lavage
  • genetics
  • pathogenesis

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Published Papers (1 paper)

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Research

13 pages, 2052 KiB  
Article
Serum KL-6 and SP-D: Markers of Lung Function in Autoimmune-Related Interstitial Lung Diseases
by Ewa Miądlikowska, Joanna Miłkowska-Dymanowska, Adam Jerzy Białas, Joanna Samanta Makowska, Anna Lewandowska-Polak, Anna Puła, Anna Kumor-Kisielewska and Wojciech Jerzy Piotrowski
Int. J. Mol. Sci. 2025, 26(3), 1091; https://doi.org/10.3390/ijms26031091 - 27 Jan 2025
Viewed by 407
Abstract
This study evaluates the usefulness of serum KL-6, SP-D and TGF-β1 levels in assessing lung impairment and predicting interstitial lung disease (ILD) short-term progression in patients with interstitial pneumonia with autoimmune features (IPAF). A total of 24 patients with IPAF, 21 with connective [...] Read more.
This study evaluates the usefulness of serum KL-6, SP-D and TGF-β1 levels in assessing lung impairment and predicting interstitial lung disease (ILD) short-term progression in patients with interstitial pneumonia with autoimmune features (IPAF). A total of 24 patients with IPAF, 21 with connective tissue disease-associated ILD (CTD-ILD) and 23 with CTD without ILD were followed for 1 year. Serum levels of KL-6, SP-D and TGF-β1 were measured and their associations with disease severity and progression were analysed. KL-6, SP-D and TGF-β1 levels were significantly higher in IPAF and CTD-ILD patients compared to CTD without ILD (p < 0.0001, p = 0.0005 and p = 0.0001, respectively). KL-6 (r = 0.45, p = 0.002) and SP-D (r = 0.35, p = 0.02) levels correlated with lung involvement in HRCT in the ILD group. In IPAF, KL-6 levels correlated with pulmonary function tests (FVC%, TLCO%, and 6MWD) and SpO2, while SP-D correlated with 6MWD and SpO2. In CTD-ILD, KL-6 and SP-D levels were positively correlated with BAL cell count (KL-6: r = 0.58, p = 0.04; SP-D: r = 0.63, and p = 0.02). KL-6 also showed a negative correlation with the time since symptom onset (r = −0.51, p = 0.02). No significant associations were found between the baseline biomarker levels and ILD progression risk. KL-6 and SP-D may serve as potential biomarkers for assessing lung impairment in IPAF, though their predictive value for short-term prognosis remains uncertain. Full article
(This article belongs to the Special Issue Molecular Diagnostics and Treatment Advances in Lung Diseases)
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