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Biomaterials and Cell–Material Interactions 2023
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Biomaterials and Cell–Material Interactions 2023

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 11061

Special Issue Editor

Dr. Axel T. Neffe

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Guest Editor
Helmholtz-Zentrum Hereon, Teltow, Germany
Interests: biobased materials; bio-inspired polymers; biofunctionalization; regenerative medicine; drug release; hydrogels; degradable polymers; peptides and peptidomimetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Generating materials to guide cellular behavior in fundamental studies has been gaining great interest, as has biomedical applications, including regenerative medicine. In this respect, the design and synthesis of biomaterials, their processing, the study of cell–material interactions, and gaining understanding of the underlying mechanisms are all continuing efforts in the field. We do not want to be limited to the knowledge that molecular structures, mechanical properties, degradation behavior, stimulus sensitivity, specific molecular interactions and the 3D forms of materials (e.g., nanoparticles, 3D scaffolds, coatings and films) are key to the performance of a material in its interaction with living systems and the environment; we want to develop quantitative relationships as well. This may include the use of theoretical models and data science approaches. Material performances may be endowed by combining biomaterials with cells or drugs. In addition, cellular and protein adsorption to materials, as well as its degradation and degradation products, may change the material’s biological effect. Therefore, the dynamic changes of a biomaterial in a biological environment over time is of particular relevance.

This Special Issue on “Biomaterials and Cell–Material Interactions 2023” focuses on these aspects of biomaterials and cell–biomaterial interaction, and we invite contributions of reviews and/or original papers reporting on recent efforts in the field of biomaterials and their wider applications.

Dr. Axel T. Neffe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • cell–material interaction
  • biomaterials
  • regenerative medicine
  • stem cells
  • cell therapy
  • nanomedicine
  • cell fate
  • nanoparticles
  • 3D scaffolds
  • biofunctionalization

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Related Special Issue

Published Papers (4 papers)

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Research

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11 pages, 5559 KiB  
Article
Composition-Dependent Protein–Material Interaction of Poly(Methyl Methacrylate-co-styrene) Nanoparticle Series
by Barbara Seifert, Stefan Baudis and Christian Wischke
Int. J. Mol. Sci. 2023, 24(22), 16390; https://doi.org/10.3390/ijms242216390 - 16 Nov 2023
Viewed by 970
Abstract
Polymer nanoparticles continue to be of high interest in life science applications. Still, adsorption processes occurring in protein-containing media and their implications for biological responses are not generally predictable. Here, the effect of nanoparticle composition on the adsorption of bovine serum albumin (BSA), [...] Read more.
Polymer nanoparticles continue to be of high interest in life science applications. Still, adsorption processes occurring in protein-containing media and their implications for biological responses are not generally predictable. Here, the effect of nanoparticle composition on the adsorption of bovine serum albumin (BSA), fibronectin (FN) and immunoglobulin G (IgG) as structurally and functionally different model proteins was explored by systematically altering the composition of poly(methyl methacrylate-co-styrene) nanoparticles with sizes in a range of about 550 nm. As determined by protein depletion from the suspension medium via a colorimetric assay, BSA and IgG adsorbed at similar quantities, while FN reached larger masses of adsorbed protein (up to 0.4 ± 0.06 µg·cm−2 BSA, 0.42 ± 0.09 µg·cm−2 IgG, 0.72 ± 0.04 µg·cm−2 FN). A higher content of styrene as the more hydrophobic polymer component enhanced protein binding, which suggests a contribution of hydrophobic interactions despite the particles exhibiting strongly negatively charged surfaces with zeta potentials of −44 to −52 mV. The quantities of adsorbed proteins were estimated to correspond to a confluent surface coverage. Overall, this study illustrated how protein binding can be controlled by systematically varying the nanoparticle bulk composition and may serve as a basis for establishing interfaces with a targeted level of protein retention and/or presentation. Full article
(This article belongs to the Special Issue Biomaterials and Cell–Material Interactions 2023)
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16 pages, 4510 KiB  
Article
Octacalcium Phosphate-Laden Hydrogels on 3D-Printed Titanium Biomaterials Improve Corrosion Resistance in Simulated Biological Media
by Aydin Bordbar-Khiabani, Ilijana Kovrlija, Janis Locs, Dagnija Loca and Michael Gasik
Int. J. Mol. Sci. 2023, 24(17), 13135; https://doi.org/10.3390/ijms241713135 - 24 Aug 2023
Cited by 13 | Viewed by 1737
Abstract
The inflammatory-associated corrosion of metallic dental and orthopedic implants causes significant complications, which may result in the implant’s failure. The corrosion resistance can be improved with coatings and surface treatments, but at the same time, it might affect the ability of metallic implants [...] Read more.
The inflammatory-associated corrosion of metallic dental and orthopedic implants causes significant complications, which may result in the implant’s failure. The corrosion resistance can be improved with coatings and surface treatments, but at the same time, it might affect the ability of metallic implants to undergo proper osteointegration. In this work, alginate hydrogels with and without octacalcium phosphate (OCP) were made on 3D-printed (patterned) titanium alloys (Ti Group 2 and Ti-Al-V Group 23) to enhance their anticorrosion properties in simulated normal, inflammatory, and severe inflammatory conditions in vitro. Alginate (Alg) and OCP-laden alginate (Alg/OCP) hydrogels were manufactured on the surface of 3D-printed Ti substrates and were characterized with wettability analysis, XRD, and FTIR. The electrochemical characterization of the samples was carried out with open circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). It was observed that the hydrophilicity of Alg/OCP coatings was higher than that of pure Alg and that OCP phase crystallinity was increased when samples were subjected to simulated biological media. The corrosion resistance of uncoated and coated samples was lower in inflammatory and severe inflammatory environments vs. normal media, but the hydrogel coatings on 3D-printed Ti layers moved the corrosion potential towards more nobler values, reducing the corrosion current density in all simulated solutions. These measurements revealed that OCP particles in the Alg hydrogel matrix noticeably increased the electrical charge transfer resistance at the substrate and coating interface more than with Alg hydrogel alone. Full article
(This article belongs to the Special Issue Biomaterials and Cell–Material Interactions 2023)
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13 pages, 5286 KiB  
Article
Time-Dependent Controlled Release of Ferulic Acid from Surface-Modified Hollow Nanoporous Silica Particles
by Tetsuo Yamaguchi, Taeho Kim, Jin-Kuen Park and Jae-Min Oh
Int. J. Mol. Sci. 2023, 24(13), 10560; https://doi.org/10.3390/ijms241310560 - 23 Jun 2023
Viewed by 1581
Abstract
Release of ferulic acid from surface-functionalized hollow nanoporous silica particles (HNSPs) was investigated in deionized water (DI water) and in ethanol. The host material, an HNSP, was synthesized in the presence of polymer and surfactant templates, and the pore as well as the [...] Read more.
Release of ferulic acid from surface-functionalized hollow nanoporous silica particles (HNSPs) was investigated in deionized water (DI water) and in ethanol. The host material, an HNSP, was synthesized in the presence of polymer and surfactant templates, and the pore as well as the surface were modified with either pentyltriethoxysilane (PTS) or octyltriethoxysilane (OTS) through silane coupling reactions. The inner hollow space occupied a volume of ~45% of the whole HNSP with a 2.54 nm pore channel in the wall. The pore size was estimated to decrease to 1.5 nm and 0.5 nm via the PTS and OTS functionalization, respectively. The encapsulation efficiencies of the HNSP (25 wt%), PTS-functionalized HNSP (PTS-HNSP, 22 wt%) and OTS-functionalized HNSP (OST-HNSP, 25 wt%) toward ferulic acid were similar, while the %release in DI water and ethanol varied following HNSP > PTS-HNSP > OTS-HNSP. Release kinetic analyses with Korsmeyer–Peppas fitting suggested a trade-off relationship between the solvent’s ability to access the HNSP and the affinity of ferulic acid to the surface, allowing us to understand the solvent’s controlled release rate and mechanism. Full article
(This article belongs to the Special Issue Biomaterials and Cell–Material Interactions 2023)
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Review

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28 pages, 2599 KiB  
Review
Current Advances in the Biomedical Applications of Quantum Dots: Promises and Challenges
by Nhi Le and Kyoungtae Kim
Int. J. Mol. Sci. 2023, 24(16), 12682; https://doi.org/10.3390/ijms241612682 - 11 Aug 2023
Cited by 22 | Viewed by 5861
Abstract
Quantum dots (QDs) are a type of nanoparticle with exceptional photobleaching-resistant fluorescence. They are highly sought after for their potential use in various optical-based biomedical applications. However, there are still concerns regarding the use of quantum dots. As such, much effort has been [...] Read more.
Quantum dots (QDs) are a type of nanoparticle with exceptional photobleaching-resistant fluorescence. They are highly sought after for their potential use in various optical-based biomedical applications. However, there are still concerns regarding the use of quantum dots. As such, much effort has been invested into understanding the mechanisms behind the behaviors of QDs, so as to develop safer and more biocompatible quantum dots. In this mini-review, we provide an update on the recent advancements regarding the use of QDs in various biomedical applications. In addition, we also discuss# the current challenges and limitations in the use of QDs and propose a few areas of interest for future research. Full article
(This article belongs to the Special Issue Biomaterials and Cell–Material Interactions 2023)
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