ijms-logo

Journal Browser

Journal Browser

Gastric Cancer: Molecular Pathways and Candidate Biomarkers 5.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 2512

Special Issue Editor


E-Mail Website
Guest Editor
Immunopathology and Oncological Biomarkers (IBO) Lab, Department of Translational Research and Advanced Diagnostics of Tumors (DRDT), Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy
Interests: biology of cancers of the gastrointestinal tract; Hodgkin's lymphoma, with a focus on infectious and autoimmune related factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous issues on related topics, namely "Molecular Features Distinguishing Gastric Cancer Subtypes", "Molecular Pathways and Candidate Biomarkers", "Gastric Cancers: Molecular Pathways and Candidate Biomarkers 3.0" and "Gastric Cancers: Molecular Pathways and Candidate Biomarkers 4.0".

Although there has been progress in the treatment of gastric cancer and a worldwide decline in its pathology, gastric cancer remains a disease characterized by uncontrolled growth and high mortality, which is mostly due to a delay in diagnosis. The epidemiology of gastric cancer has changed in the last 25 years, with a decline in the intestinal type and stomach antral localization but an increase in presence in young people and in the diffuse type. In recent decades, the introduction of high-throughput technologies that are able to analyse several gastric cancers from small biological samples has caused significant advances in the development of biomarkers in oncology. Molecular pathways and biomarkers molecules are potentially useful for GC diagnosis because they increase the accuracy of diagnosis (e.g., the nanomolecule used in confocal laser endomicroscopy) and can be used to select patients at risk for GC at an early stage (e.g., ABC pepsinogen test in japan) and also to propose new GC classifications (e.g., TCAG, ACRG). This research has produced important results that enable us to better understand gastric cancer pathogenesis and individualized important targetable molecules used to achieve novel drug targets and new treatment strategies in advanced gastric cancer. Target therapies are now ongoing, with moderate benefits seen in some subsets of gastric cancer papers, and several trials are underway to achieve an increase in the survival benefit of patients with gastric cancer. The aim of this Special Issue is to provide new findings regarding molecular pathways and biomarkers that could improve the diagnosis and/or the prognostic classification of gastric cancer, and to resume their potential application in GC detection and classification, or in clinics.

Dr. Valli De Re
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • pathogenesis
  • immune response
  • Helicobacter pylori
  • genomics
  • proteomics
  • diagnostic marker
  • prognostic marker

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

18 pages, 2480 KiB  
Review
Historical and Molecular Perspectives on the Presence of Helicobacter pylori in Latin America: A Niche to Improve Gastric Cancer Risk Assessment
by Roxana González-Stegmaier, Patricia Aguila-Torres and Franz Villarroel-Espíndola
Int. J. Mol. Sci. 2024, 25(3), 1761; https://doi.org/10.3390/ijms25031761 - 1 Feb 2024
Cited by 4 | Viewed by 2004
Abstract
Helicobacter pylori (H. pylori) is responsible for causing chronic gastritis, which can cause peptic ulcer and premalignant lesions such as atrophic gastritis, intestinal metaplasia, and dysplasia, with the risk of developing gastric cancer. Recent data describe that H. pylori colonizes the [...] Read more.
Helicobacter pylori (H. pylori) is responsible for causing chronic gastritis, which can cause peptic ulcer and premalignant lesions such as atrophic gastritis, intestinal metaplasia, and dysplasia, with the risk of developing gastric cancer. Recent data describe that H. pylori colonizes the gastric mucosa of more than 50% of the world’s population; however, this bacterium has been described as infecting the human population since its prehistory. This review focuses on the populations and subpopulations of H. pylori, differentiated by the polymorphisms present in their constitutive and virulence genes. These genes have spread and associated with different human populations, showing variability depending on their geographical distribution, and have evolved together with the human being. The predominant genotypes worldwide, Latin America and Chile, are described to understand the genetic diversity and pathogenicity of H. pylori in different populations and geographic regions. The high similarity in the sequence of virulence genes between H. pylori strains present in Peruvian and Spanish natives in Latin America suggests a European influence. The presence of cagA-positive strains and vacA s1 m1 allelic variants is observed with greater prevalence in Chilean patients with more severe gastrointestinal diseases and is associated with its geographical distribution. These findings highlight the importance of understanding the genetic diversity of H. pylori in different regions of the world for a more accurate assessment of the risk of associated diseases and their potential impact on health. Full article
(This article belongs to the Special Issue Gastric Cancer: Molecular Pathways and Candidate Biomarkers 5.0)
Show Figures

Graphical abstract

Back to TopTop