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New Molecular Insights and Therapeutic Strategies for Ocular Vascular Pathologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 716

Special Issue Editor


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Guest Editor
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Interests: choroidal neovascularization; eye; retina; retinal vessels; retinal neovascularization; vascular endothelial growth factor; drug delivery therapy

Special Issue Information

Dear Colleagues,

We invite you to contribute to our Special Issue entitled “New Molecular Insights and Therapeutic Strategies for Ocular Vascular Pathologies”. 

This Special Issue aims to highlight innovative research and reviews on the pathogenesis and treatment of ocular vascular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, which remain the leading causes of vision impairment and blindness globally. Progress in molecular biology and biotechnology has deepened our understanding of the underlying mechanisms of these conditions, paving the way for innovative therapeutic strategies.

We welcome papers that address molecular insights, including the VEGF pathway, the role of inflammation and cytokines, and the importance of oxidative stress in ocular pathologies. In addition, we are interested in papers investigating recent advances in therapeutic strategies for retinal and choroidal diseases, including new approaches for delivering anti-VEGF therapies, anti-inflammatory agents, gene therapy, antioxidants, neuroprotective agents, and stem cell therapy.

We look forward to your valuable contributions to this Special Issue, which aims to advance our understanding and treatment of ocular vascular pathologies.

This Special Issue is now open for submissions. If you are interested in contributing your work, please send a short abstract or tentative title to the Guest Editor or Editorial Office.

Dr. Raquel Lima e Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • VEGF pathway
  • anti-VEGF therapy
  • retinal neovascularization
  • choroidal neovascularization
  • oxidative stress

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Published Papers (1 paper)

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Research

11 pages, 1397 KiB  
Article
Prolonged Photobiomodulation with Deep Red Light Mitigates Incipient Retinal Deterioration in a Mouse Model of Type 2 Diabetes
by Gabriela Opazo, Felipe Tapia, Alejandra Díaz, Alex H. Vielma and Oliver Schmachtenberg
Int. J. Mol. Sci. 2024, 25(22), 12128; https://doi.org/10.3390/ijms252212128 - 12 Nov 2024
Viewed by 337
Abstract
Diabetic retinopathy is a prevalent complication of type 2 diabetes mellitus, characterized by progressive damage to the retinal structure and function. Photobiomodulation therapy, using red or near-infrared light, has been proposed as a non-invasive intervention to mitigate retinal damage, but has been tested [...] Read more.
Diabetic retinopathy is a prevalent complication of type 2 diabetes mellitus, characterized by progressive damage to the retinal structure and function. Photobiomodulation therapy, using red or near-infrared light, has been proposed as a non-invasive intervention to mitigate retinal damage, but has been tested generally with short-term stimuli. This study aimed to evaluate the effects of prolonged photobiomodulation with deep red light on retinal structure and function in a type 2 diabetes mouse model. Transgenic LepRdb/J (db/db) mice were exposed to photobiomodulation therapy via LED devices emitting 654 nm light for 12 h daily over ten weeks and compared to untreated mice. Retinal function was evaluated by flash electroretinography, while structural changes were assessed through histology and immunohistochemistry to detect astro- and microgliosis. At 33 weeks of age, db/db mice were obese and severely diabetic, but exhibited only incipient indicators of retinal deterioration. Electroretinogram b-wave peak latencies were prolonged at intermediate flash intensities, while the outer plexiform layer displayed significantly elevated IBA1 expression. Photobiomodulation therapy prevented these two markers of early retinal deterioration but had no effect on other morphological and functional parameters. Photobiomodulation is well-tolerated and maintains potential as a complementary treatment option for diabetic retinopathy but requires further optimization of therapeutic settings and combinatory treatment approaches. Full article
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