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Emerging Advances in Cancer Biomarkers: Machine Learning, Radiomics, Genomics, and More

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 1583

Special Issue Editors

Special Issue Information

Dear Colleagues,

In the last decade, the exponential growth in human genomics has enabled personalized medicine to enter the realm of diagnostics, prognostics and treatment for cancers. More recently, human radiomics has also been implicated in medical-image-guided precision medicine for cancers. Genomics and radiomics can be mutually linked and integrated to form an emerging discipline named “radiogenomics”, which aims to correlate imaging features with genetic characteristics.

Advances in artificial intelligence and machine learning have spurred significant interest in precision medicine. The application of these techniques in the analysis of genomics, radiomics and/or radiogenomics provides an opportunity for many aspects of clinical oncology, including the identification of biomarkers, the development of therapeutics, and the clarification of the mechanisms implicated.

This Special Issue aims to highlight the two omics bases involved in the improvement of precision oncology. Research areas may include (but are not limited to) genomics, radiomics, radiogenomics, transcriptomics, pharmacogenetics, and the machine learning approach. We welcome basic research papers addressing cancer biomarkers, and professional opinions and reviews investigating the broad role of molecular biology and imaging in the clinical management of cancer. We look forward to receiving your contributions.

Dr. Hung-Yu Lin
Dr. Pei-Yi Chu
Guest Editors

Manuscript Submission Information

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Keywords

  • cancers
  • biomarkers
  • precision medicine
  • artificial intelligence
  • machine learning
  • radiomics
  • genomics
  • radiogenomics
  • multi-omics
  • pharmacogenetics

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Published Papers (1 paper)

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Research

18 pages, 19195 KiB  
Article
Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven Seven-Gene Stemness Signature That Predicts Progression
by Agustina Sabater, Pablo Sanchis, Rocio Seniuk, Gaston Pascual, Nicolas Anselmino, Daniel F. Alonso, Federico Cayol, Elba Vazquez, Marcelo Marti, Javier Cotignola, Ayelen Toro, Estefania Labanca, Juan Bizzotto and Geraldine Gueron
Int. J. Mol. Sci. 2024, 25(21), 11356; https://doi.org/10.3390/ijms252111356 - 22 Oct 2024
Viewed by 1112
Abstract
Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signature using advanced machine learning techniques, including Random Forest and Lasso regression, applied [...] Read more.
Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signature using advanced machine learning techniques, including Random Forest and Lasso regression, applied to large-scale transcriptomic datasets. The resulting seven-gene signature (KMT5C, DPP4, TYMS, CDC25B, IRF5, MEN1, and DNMT3B) was validated across independent cohorts and patient-derived xenograft (PDX) models. This signature demonstrated strong prognostic value for progression-free, disease-free, relapse-free, metastasis-free, and overall survival. Importantly, the signature not only identified specific NEPC subtypes, such as large-cell neuroendocrine carcinoma, which is associated with very poor outcomes, but also predicted a poor prognosis for PCa cases that exhibit this molecular signature, even when they were not histopathologically classified as NEPC. This dual prognostic and classifier capability makes the seven-gene signature a robust tool for personalized medicine, providing a valuable resource for predicting disease progression and guiding treatment strategies in PCa management. Full article
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