The Role of Sphingolipids in Skin Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 5511
Special Issue Editor
Interests: photo-aging/fibroblast biology; atopic dermatitis/sphingolipid metabolism; melanogenesis/melanocyte biology; keratinization/keratinocyte biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sphingolipids in the skin play a crucial role in skin health and diseases. The most abundant sphingolipids in the skin are ceramides, which are found in great numbers, especially in the most upper stratum corneum layers. Since stratum corneum ceramides have a water-holding function and serve as a percutaneous permeability barrier by forming a multi-lamellar structure between the stratum corneum layers, their deficiency provokes skin diseases characterized by dry and barrier-disrupted skin, which include diseases, such as Niemann–Pick and Gaucher, as well as atopic dermatitis associated with the genetic defects of sphingomyelinase and beta-glucocerebrosidase, and the abnormal expression of sphingomyelin deacylase, recently identified as a beta-subunit of acid ceramidase. Acid ceramidase hydrolyzes the sphingolipid and ceramide into sphingosine and free fatty acids, in order to act as a rheostat that controls the levels of ceramide, sphingosine (a potent antimicrobial agent for St. Aureus) and sphingosine-1-phosphate (acting as an intracellular signaling factor) in cells and/or extracellular spaces. Farber disease is a genetic disorder resulting from a deficiency of acid ceramidase. Despite the many discovered mechanisms involved in the role of sphingolipids, there are stilll several unresolved mechanisms. For instance, how is sphingomyelin deacylase generated from acid ceramidase, which leads to a ceramide deficiency in atopic dermatitis? What is a precise role of acid ceramidase in skin cancers? How does a potent signaling factor such as sphingosine-1-phosphate contribute to skin health and diseases? Most importantly, what are biological factors or chemicals used to ameliorate ceramide or sphingosine deficiencies, as well as regulate sphingosine-1-phosphate levels in the intracellular space? This Special Issue, entitled “The Role of Sphingolipids in Skin Health and Diseases”, aims to provide a summary of these emerging fields, with an emphasis on novel evidence in the biological function of sphingolipids, and novel results on the pathophysiological molecular mechanisms of sphingolipids-associated skin diseases, especially atopic dermatitis and xerosis. This Special Issue will collate original research articles, as well as full reviews, including perspectives from the field on the current understanding of molecular mechanisms involved in atopic dermatitis and other sphingolipids-associated skin diseases. Manuscripts on the molecular mechanisms of new anti-atopic agents, the introduction of ideas for new skin anti-atopic agents, and new techniques for measuring the level of atopic dermatitis severity are all welcome.
Prof. Dr. Genji Imokawa
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sphingolipids
- ceramides
- atopic dermatitis
- skin health and diseases
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
