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Stem Cells and Cardiovascular Diseases—More than Just about Cells
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Stem Cells and Cardiovascular Diseases—More than Just about Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 4171

Special Issue Editor

Dr. Katherine Sattler

E-Mail Website
Guest Editor
First Department of Medicine, Cardiology, Angiology, Hemostaseology and Internal Intensive Care Medicine, University Medical Centre Mannheim, 68167 Mannheim, Germany
Interests: cardiomyocyte function; ischemia; inflammation and metabolic models; arrhythmias; molecular biomarkers; intracellular pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The term “cardiovascular diseases” includes disorders of blood vessels which supply either single organs such as the brain (cerebrovascular) or the heart (coronary heart), or whole limbs (peripheral artery disease). Disorders of each of these vascular beds can have deleterious effects such as ischemic stroke, myocardial infarction, heart failure, or critical limb ischemia. Since the success of stem-cell transplantation for the treatment of hematologic malignancies in the late 1990s, a plethora of pre-clinical and clinical studies were undertaken to attenuate tissue injury and stimulate tissue regeneration by use of cell-based therapy in cardiovascular diseases as well. From the early attempts of injecting cardiomyocytes into the scar area of infarcted hearts, this research field has advanced towards the use of bone marrow-derived mononuclear cells, mesenchymal stem cells, or embryonic- or induced pluripotent stem (iPS) cell-derived differentiated cells, the use of bioengineered matrices of various cellular composition, and even the cell-free approach by use of exosome transfer. During the development of this research field, the role of the paracrine function of the injected cells and their molecular interaction with cells and the immune system of the host has received increasing attention, as has the importance of microvascular repair and angiogenesis. Recent advances in genome editing might offer the possibility to tailor cells and their secretome individually toward personalized medicine.

We are pleased to invite you to share your results of current investigations on somatic stem cells (bone marrow of mesenchymal (stem) cells, cardiac stem or progenitor cells) or iPS-derived cells in cardiovascular research, with a focus on the paracrine function of these cells, their molecular interplay with a potential host, and of re-programming or adjusting their secretome using gene editing or environmental changes. In this line, reports on investigations of acellular models are welcome as well.

This Special Issue aims to increase the knowledge of cell-based therapies for vascular diseases including myocardial diseases, cerebral diseases or peripheral artery diseases. The emphasis lies on studying the molecular mechanisms of the cell therapies to provide the mechanistic base for future clinical applications.

Potential topics include, but are not limited to:

  • Different models of cardiomyocyte, vascular or neuronal ischemia treated with stem cells or iPS-derived cells in vitro
  • Analysis of stem cell secretome under different culturing conditions
  • Analysis of cell–cell interaction of stem cells with tissue resident or immune cells
  • Modeling stem cell function to the need in different disease models
  • Acellular treatment models of cardiomyocyte, vascular or neuronal ischemia, i.e., secretome transfer
  • Improvement of endothelial cell function by modified paracrine functions of stem cells

Dr. Katherine Sattler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • somatic stem cells or iPS-derived cells
  • paracrine cell function
  • secretome modeling
  • microvascular repair
  • tissue regeneration
  • genome editing of stem cells
  • environmental interference with stem cell function
  • in vitro and preclinical model

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Published Papers (2 papers)

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Research

30 pages, 3625 KiB  
Article
Development of a Bmi1+ Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche
by Guillermo Albericio, Marina Higuera, Paula Araque, Cristina Sánchez, Diego Herrero, Miguel A. García-Brenes, Laura Formentini, José Luis Torán, Carmen Mora and Antonio Bernad
Int. J. Mol. Sci. 2024, 25(16), 8815; https://doi.org/10.3390/ijms25168815 - 13 Aug 2024
Viewed by 1112
Abstract
The adult mammalian heart has been demonstrated to be endowed with low but real turnover capacity, especially for cardiomyocytes, the key functional cell type. The source, however, of that turnover capacity remains controversial. In this regard, we have defined and characterized a resident [...] Read more.
The adult mammalian heart has been demonstrated to be endowed with low but real turnover capacity, especially for cardiomyocytes, the key functional cell type. The source, however, of that turnover capacity remains controversial. In this regard, we have defined and characterized a resident multipotent cardiac mouse progenitor population, Bmi1+DR (for Bmi1+ Damage-Responsive cells). Bmi1+DR is one of the cell types with the lowest ROS (Reactive Oxygen Species) levels in the adult heart, being particularly characterized by their close relationship with cardiac vessels, most probably involved in the regulation of proliferation/maintenance of Bmi1+DR. This was proposed to work as their endothelial niche. Due to the scarcity of Bmi1+DR cells in the adult mouse heart, we have generated an immortalization/dis-immortalization model using Simian Vacuolating Virus 40-Large Antigen T (SV40-T) to facilitate their in vitro characterization. We have obtained a heterogeneous population of immortalized Bmi1+DR cells (Bmi1+DRIMM) that was validated attending to different criteria, also showing a comparable sensitivity to strong oxidative damage. Then, we concluded that the Bmi1-DRIMM population is an appropriate model for primary Bmi1+DR in vitro studies. The co-culture of Bmi1+DRIMM cells with endothelial cells protects them against oxidative damage, showing a moderate depletion in non-canonical autophagy and also contributing with a modest metabolic regulation. Full article
(This article belongs to the Special Issue Stem Cells and Cardiovascular Diseases—More than Just about Cells)
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14 pages, 2925 KiB  
Article
Cardiac Progenitor Cells and Adipocyte Stem Cells from Same Patients Exhibit In Vitro Functional Differences
by Anthony Soonseng Yee-Goh, Atsushi Yamauchi, Isabelle van Hout, Jayanthi Bellae Papannarao, Ramanen Sugunesegran, Dominic Parry, Philip Davis and Rajesh Katare
Int. J. Mol. Sci. 2022, 23(10), 5588; https://doi.org/10.3390/ijms23105588 - 17 May 2022
Cited by 1 | Viewed by 2259
Abstract
Cardiac progenitor cells (CPCs) and adipocyte stem cells (ASCs) are widely tested for their efficacy in repairing the diseased heart with varying results. However, no study has directly compared the functional efficacy of CPCs and ASCs collected from the same patient. CPCs and [...] Read more.
Cardiac progenitor cells (CPCs) and adipocyte stem cells (ASCs) are widely tested for their efficacy in repairing the diseased heart with varying results. However, no study has directly compared the functional efficacy of CPCs and ASCs collected from the same patient. CPCs and ASCs were isolated from the right atrial appendage and epicardial adipose tissue of the same patients, using explant culture. The flow cytometry analysis confirmed that both the cell types express common mesenchymal stem cells markers CD90 and CD105. ASCs, in addition, expressed CD29 and CD73. The wound-healing assay demonstrated that CPCs migrate faster to cover the wound area. Both cell types were resistant to hypoxia-induced cell death when exposed to hypoxia and serum deprivation; however, the ASCs showed increased proliferation. Conditioned medium (CM) collected after culturing serum-deprived CPCs and ASCs showed differential secretion patterns, with ASC CM showing an increased IGF-1 level, while CPC CM showed an increased FGF level. Only CPC CM reduced hypoxia-induced apoptosis in AC-16 human ventricular cardiomyocytes, while vascular network formation by endothelial cells was comparable between CPC and ASC CM. In conclusion, ASCs and CPCs exhibit differential characteristics within the same patient, and in vitro studies showed that CPCs have marginally superior functional efficacy. Full article
(This article belongs to the Special Issue Stem Cells and Cardiovascular Diseases—More than Just about Cells)
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