Human Papillomavirus and Cancers: Advances and Future Prospects
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 5845
Special Issue Editors
Interests: oncogenic viruses; virus-host interactions; viral genome editing; viral evolution
Special Issues, Collections and Topics in MDPI journals
Interests: molecular virology; oncology; HPV; cervical cancer; molecular phylogenetics; biomarkers; HPV genotyping assays; genetics
Special Issue Information
Dear Colleagues,
Human Papillomaviruses (HPVs) are non-enveloped, double–stranded circular DNA viruses that infect basal keratinocytes of mucosal and cutaneous epithelia. Persistent high-risk HPV infection is the etiologic agent of approximately all cervical cancer incidences and of a considerable part of various types of malignancies including vulvar, vaginal, anal, penile, oropharyngeal and skin cancers. Although cytological testing (the Papanicolaou, Pap test), HPV screening and HPV vaccination programs have reduced the rates of cervical malignancy, it remains a major public health problem, globally.
HPVs have developed several molecular approaches in order to inhibit cell-cycle arrest and apoptosis. The extensive expression of viral oncoproteins and the integration of viral DNA into the host chromosome are involved in chromosomal instability and the accumulation of DNA damage in the infected cells, thus leading to cancer development. Moreover, various epigenetic changes, including viral or host genes΄ methylation and miRNAs differential expression play an important role in host-viral interplay. The HPV tumorigenic capacity has also been associated with specific nucleotide and amino-acid substitutions, characterizing specific genotypes and variant lineages, that have been reported globally.
The aim of this special issue is to better understand the molecular mechanisms that are implicated in HPV carcinogenicity. We welcome submissions of research articles and reviews focused on the following potential topics (but are not limited to): molecular mechanisms (e.g epigenetic mechanisms, viral integration events, viral oncoproteins deregulation), HPV genetic variability, biomarkers development, molecular epidemiology and new HPV detection and genotyping molecular assays in order to meet expert views, state of the art and recent advancements in the field of HPV, in the present Special Issue of International Journal of Molecular Sciences.
Dr. Christine Kottaridi
Dr. Dimitris Tsakogiannis
Dr. Zaharoula Kyriakopoulou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- α-HPV
- β-ΗPV
- γ-HPV
- variability
- epidemiology
- oncogenic viruses
- methylation
- miRNA
- biomarkers
- molecular typing
- carcinogenesis
- cervical cancer
- oropharyngeal cancer
- skin cancer
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
