Advances in Tumor-Associated Microbiome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 8336
Special Issue Editors
Interests: head and neck cancers; experimental therapeutics—drug development; immune biomarkers; human papillomavirus; microbiome
Special Issue Information
Dear Colleagues,
The study of the human microbiome in oncology is a growing and rapidly evolving field. Accumulating evidence indicates an association between microbiome and cancer, from oncogenesis and cancer progression to resistance or sensitivity to specific anticancer therapies. Microbial communities located either in the tumor or within its body compartment - also known as tumor-associated microbiome - seem to interact with the local microenvironment and the tumor immune contexture, enabling and/or facilitating tumorigenesis and progression, ultimately impacting on treatment outcome. Pre-clinical research focusing on causality and mechanistic pathways, proof-of-concept studies as well as methodology standardization across research groups and institutions are key areas for development that will be crucial to understand the potential clinical utility of tumor-associated microbiome in cancer patients. This Special Issue will be dedicated to the impact of microbiome on cancer development and progression, with a particular focus on tumor-associated microbiome, welcoming all those studies that will help to clarify and expand on how microorganisms interact with cancer cells and immune cells within the tumor microenvironment. Investigations on tumor-specific interactions with local microbiome at a molecular level are of particular interest. Research studies evaluating the relationship between tumor microbiome and response to cancer therapies including radiotherapy and systemic treatments (ie. Cytotoxic chemotherapy, molecular targeted agents and immunotherapies) are highly encouraged.
Dr. Marc Oliva
Dr. Laia Alemany
Guest Editors
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Keywords
- cancer
- carcinogenesis
- microbiome
- tumor-associated microbiome
- oral microbiome
- gut microbiome
- 16S RNAseq
- metagenomics
- cancer cell-microbiome interactions
- immune-cell microbiome interactions
- molecular pathways
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