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Research on Cyclodextrin

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1109

Special Issue Editor


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Guest Editor
Institute of Biomolecular Chemistry CNR-ICB, Via Paolo Gaifami 18, 95125 Catania, Italy
Interests: organic chemistry; polymer science; mass spectrometry

Special Issue Information

Dear Colleagues,

Cyclodextrins (CyDs), a cyclic oligosaccharide with a hydrophobic internal cavity, are characterized by exceptional inclusion capability and molecular recognition properties that allow them to encapsulate hydrophobic molecules through a host–guest interaction, playing a crucial role in pharmaceuticals, food, agriculture, biotechnology, chemicals, and environmental applications. Over the past 30 years, researchers have developed cyclodextrin-based polymers and nanocomposites to improve their adsorptive capacity and selectivity. These materials combine the inclusion properties of cyclodextrins with the stability and robustness of polymeric frameworks. Moreover, the functionalization of cyclodextrins with various chemical groups can further improve their binding affinity and selectivity for specific molecules. Additionally, these materials can be regenerated and reused, making them cost-effective and sustainable.

This Special Issue aims to bring to the scientific community the latest advancements in the development of novel and smart CyD-based systems, ranging from pharmaceutical to environmental field applications. To this end, scientists involved in this multidisciplinary research field are invited to contribute by submitting reviews or original articles presenting their valuable results in this collection.

Dr. Valentina Giglio
Guest Editor

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Keywords

  • drug delivery systems
  • polymeric cyclodextrin
  • pollution removal
  • sponge-like material
  • selective targeting systems
  • catalyst

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Published Papers (1 paper)

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Research

21 pages, 6576 KiB  
Article
Impact of Methylated Cyclodextrin KLEPTOSE® CRYSMEB on Inflammatory Responses in Human In Vitro Models
by Damien Truffin, Flora Marchand, Mathias Chatelais, Gérald Chêne, Laure Saias, Frauke Herbst, Justin Lipner and Alastair J. King
Int. J. Mol. Sci. 2024, 25(17), 9748; https://doi.org/10.3390/ijms25179748 - 9 Sep 2024
Viewed by 905
Abstract
KLEPTOSE® CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol complexation and immune response, however, its impact on inflammatory cascade pathways is not [...] Read more.
KLEPTOSE® CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol complexation and immune response, however, its impact on inflammatory cascade pathways is not clear. Thus, the impact of KLEPTOSE® CRYSMEB on various pharmacological targets was assessed using human umbilical vein endothelial cells under physiological and inflammatory conditions, followed by screening against twelve human primary cell-based systems designed to model complex human tissue and disease biology of the vasculature, skin, lung, and inflammatory tissues using the BioMAP® Diversity PLUS® panel. Finally, its anti-inflammatory mechanism was investigated on peripheral blood mononuclear cells to evaluate anti-inflammatory or pro-resolving properties. The results showed that KLEPTOSE® CRYSMEB can modulate the immune system in vitro and potentially manage vascular issues by stimulating the expression of molecules involved in the crosstalk between immune cells and other cell types. It showed anti-inflammatory effects that were driven by the inhibition of pro-inflammatory cytokine secretion and could have different impacts on different tissue types. Moreover, this cyclodextrin showed no clear impact on pro-resolving lipid mediators. Additionally, it appeared that the mechanism of action of KLEPTOSE® CRYSMEB seems to not be shared by other well-known anti-inflammatory molecules. Finally, KLEPTOSE® CRYSMEB may have an anti-inflammatory impact, which could be due to its effect on receptors such as TLR or direct complexation with LPS or PGE2, and conversely, this methylated cyclodextrin could stimulate a pro-inflammatory response involving lipid mediators and on proteins involved in communication with immune cells, probably via interaction with membrane cholesterol. Full article
(This article belongs to the Special Issue Research on Cyclodextrin)
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