Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 263
Special Issue Editor
Interests: epigenetics; molecular biology; biomarkers; Keap1; Nrf2; Notch; oxidative stress; lung cancer; next generation sequencing; resistance; tyrosine kinase inhibitors
Special Issue Information
Dear Colleagues,
Overall, lung cancer remains one of the major causes of cancer-related deaths worldwide. Despite the big efforts in ameliorating therapeutic strategies, both intrinsic and acquired resistance represent a concrete obstacle to the effectiveness of long-term treatment, resulting in ineffective therapeutic action and poor prognosis of lung cancer patients. Resistance mechanisms currently include genetic mutations and/or epigenetic changes, unregulated overexpression of drug efflux pumps, reduced oxygen availability, genomic instability and other pathological molecular events. In this context, the deregulation of epigenetic mechanisms, as well as DNA methylation, histone modification, and non-coding RNA regulation, could contribute to tumor resistance. To this purpose, a comprehensive overview of the current knowledge about several mechanisms responsible for targeting genetic and/or epigenetic factors linked to therapeutic resistance could be an effective strategy to reverse or overcome acquired drug resistance in patients with solid cancer, particularly in lung cancer patients.
This special issue aims to focus on the understanding of current landscape of intrisinic and acquired resistance in lung cancer cells and patients after therapy and the potential interventions to overcome these resistance mechanisms.
We encourage contributions of original research articles and reviews in the field of both genetic and epigenetic mechanisms related to lung cancer research.
Dr. Federico Pio Fabrizio
Guest Editor
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Keywords
- lung cancer
- NSCLC
- cancer therapy
- resistance
- DNA methylation
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