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Health Benefits of Catechins

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 1208

Special Issue Editor

Special Issue Information

Dear Colleagues,

Catechin is an important phenolic compound extracted from tea and other natural plants, it’s the main substance of tea polyphenols to play the biological active role. The chemical structure of catechins shows that they contain multiple phenolic hydroxyl groups, one of the reasons for its biological function is the high activity of phenol hydroxyl group, which makes it the first to be attacked by foreign harmful substances and protect normal tissues from being damaged. Most research has shown that catechin have many functions, such as preventing cardiovascular diseases, anti-tumor, anti-oxidation. Therefore catechins are recognized as a natural, efficient, green and safe alternative to antibiotics. The study on the biological activity of catechins is of great social benefit to the development of drugs for the treatment of various diseases.

Dr. Elena Azzini
Guest Editor

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Keywords

  • catechins
  • diseases prevention
  • antioxidant
  • molecular mechanism
  • epicatechin

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Published Papers (1 paper)

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Research

12 pages, 1548 KiB  
Article
Inhibitory Effects of New Epicatechin Oligomers on Nitric Oxide Production
by Gyeong Han Jeong, Hanui Lee, Byung Yeoup Chung and Hyoung-Woo Bai
Int. J. Mol. Sci. 2024, 25(20), 11022; https://doi.org/10.3390/ijms252011022 - 14 Oct 2024
Viewed by 553
Abstract
The primary aim of this research was to identify the structural characteristics of three newly derived procyanidins from cold plasma-treated (–)-epicatechin, known for their anti-inflammatory properties. The newly generated compounds were isolated through column chromatography, and their chemical structures were elucidated through spectroscopic [...] Read more.
The primary aim of this research was to identify the structural characteristics of three newly derived procyanidins from cold plasma-treated (–)-epicatechin, known for their anti-inflammatory properties. The newly generated compounds were isolated through column chromatography, and their chemical structures were elucidated through spectroscopic data analyses, including both one-dimensional and two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry (MS) techniques. Furthermore, their absolute configurations were determined via circular dichroism (CD) spectroscopy. The inhibitory activity of the isolated compounds on nitric oxide (NO) production and expression levels of inducible NO synthase (iNOS) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages was evaluated. Three new procyanidins—methylenetrisepicatechin (2), isomethylenetrisepicatechin (3), and methylenebisepicatechin (4)—along with two reported dimeric flavan-3-ols (5 and 6), were identified from plasma-treated (–)-epicatechin (1). The unique oligomerized products 2 and 3 linked by methylene bridges significantly suppressed both NO production and iNOS expression, demonstrating higher anti-inflammatory activities in LPS-stimulated RAW 264.7 cells compared with the parent compound. The newly oligomerized procyanidins have potential applications in the treatment of inflammatory diseases owing to their significant anti-inflammatory properties. Full article
(This article belongs to the Special Issue Health Benefits of Catechins)
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