Molecular Mechanisms and Treatment of Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 1235
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is a global public health problem with adverse outcomes of kidney failure, cardiovascular disease, and premature death. The prevalence of CKD has been increasing at an alarming rate over the past two decades as a result of the ageing population and growing prevalence of diabetes, hypertension, and obesity, exacerbated by the frequent occurrence of superimposed acute kidney injury. A forecasting analysis suggests that the number of global Years of Life Lost (YLLs) due to CKD will increase from ~26 million in 2016 to 52.5 million in 2040, and deaths will rise from 1.2 million in 2016 to 3.1 million in 2040. Despite targeted control of diabetes, blood pressure, hyperlipidemia, and proteinuria, a large proportion of patients with CKD eventually develop renal failure. Although intensive studies to identify the cellular and molecular mechanisms in CKD have been performed, the exact mechanisms of CKD development remain unknown. The current clinical strategies for CKD are largely ineffective. Thus, discovering novel mechanisms and developing innovative strategies are urgently needed to both prevent and treat CKD. Currently, it seems that the therapies using stem cells and stem cell-derived extracellular vesicles may widen the scope of CKD treatment in the future.
Dr. Xinming Chen
Guest Editor
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Keywords
- diabetes
- cardiovascular diseases
- nephrology
- diabetic nephropathy
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