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Jaw Bone Disorders—Temporomandibular Joint Disorders, Periodontal Pathology and Others

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 7579

Special Issue Editor

Columbia University College of Dental Medicine, New York, NY 10019, USA
Interests: alveolar bone; estrogen; temporomandibular joint disease; orthodontics; HIV

Special Issue Information

Dear Colleagues,

The jaw bones (maxilla and mandible) are unique developmentally, functionally and in their disease affliction. For example, jaw bones are different than long bones in that they are derived from neural crest cells, are formed by intramembranous bone formation, are exposed to the oral cavity and are predominantly loaded by forces of mastication.

Temporomandibular joint, periodontal disease and bisphosphonate-induced osteonecrosis are examples of diseases that afflict the jaw bones and their associated anatomical structures. Surprisingly, there has been little progress in the treatment and the prevalence of these specific jaw diseases in the past few decades. Therefore, the goal of this Special Issue is to gain knowledge of the unique biology of the jaw bones in order to better understand the etiology of jaw-specific diseases. Articles dealing with the jaws’ response to mechanical loading, pharmaceuticals and hormones are encouraged. In addition, articles dealing with jaw-specific bone, ligament and soft tissue remodeling, immunology and regeneration are also invited to this Special Issue. It is hoped that better understanding of the uniqueness of the jaw would lead to new treatment modalities for jaw diseases.

Dr. Sunil Wadhwa
Guest Editor

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Keywords

  • temporomandibular
  • alveolar bone
  • periodontal diseases
  • periodontal ligament
  • mastication
  • mandible
  • maxilla

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Published Papers (2 papers)

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11 pages, 1626 KiB  
Article
Analysis of SIRT1 Gene SNPs and Clinical Characteristics in Medication-Related Osteonecrosis of the Jaw
by Bence Bojtor, Mihaly Vaszilko, Richard Armos, Balint Tobias, Janos Podani, Szofia Szentpeteri, Bernadett Balla, Balazs Lengyel, Henriett Piko, Anett Illes, Andras Kiss, Zsuzsanna Putz, Istvan Takacs, Janos P. Kosa and Peter Lakatos
Int. J. Mol. Sci. 2024, 25(7), 3646; https://doi.org/10.3390/ijms25073646 - 25 Mar 2024
Cited by 1 | Viewed by 1456
Abstract
Certain genetic factors, including single-nucleotide polymorphisms (SNPs) in the SIRT1 gene, have been linked to medication-related osteonecrosis of the jaw (MRONJ). This study examined four SNPs in the SIRT1 gene and implemented multivariate statistical analysis to analyze genetic and clinical factors in MRONJ [...] Read more.
Certain genetic factors, including single-nucleotide polymorphisms (SNPs) in the SIRT1 gene, have been linked to medication-related osteonecrosis of the jaw (MRONJ). This study examined four SNPs in the SIRT1 gene and implemented multivariate statistical analysis to analyze genetic and clinical factors in MRONJ patients. Genomic DNA was isolated from peripheral blood samples of 63 patients of European origin treated for MRONJ, and four SNP genotypes in the gene encoding the SIRT-1 protein were determined by Sanger sequencing. The allele frequencies measured in the MRONJ population were compared with allele frequencies measured in the European population in the National Center for Biotechnology Information Allele Frequency Aggregator (NCBI ALFA) database. Genetic and clinical factors were examined with multivariate statistical analysis. A C:A allele distribution ratio of 77.8:22.2 was measured in the rs932658 SNP. In the ALFA project, a C:A allele distribution ratio of 59.9:40.1 was detected in the European population, which was found to be a significant difference (p = 4.5 × 10−5). Multivariate statistical analysis revealed a positive correlation (0.275) between the genotype of SNP rs932658 and the number of stages improved during appropriate MRONJ therapy. It is concluded that allele A in SNP rs932658 in the SIRT1 gene acts as a protective factor in MRONJ. Full article
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21 pages, 1536 KiB  
Review
Oral Pyogenic Granuloma: A Narrative Review
by Sarah Monserrat Lomeli Martinez, Nadia Guadalupe Carrillo Contreras, Juan Ramón Gómez Sandoval, José Sergio Zepeda Nuño, Juan Carlos Gomez Mireles, Juan José Varela Hernández, Ana Esther Mercado-González, Rubén Alberto Bayardo González and Adrián Fernando Gutiérrez-Maldonado
Int. J. Mol. Sci. 2023, 24(23), 16885; https://doi.org/10.3390/ijms242316885 - 28 Nov 2023
Cited by 6 | Viewed by 5670
Abstract
Pyogenic granuloma (PG) is a benign vascular lesion found predominantly in the oral cavity. Characterized by rapid growth and propensity to bleed, PG presents diagnostic challenges due to its similarity and alarming proliferation. This narrative review synthesizes current knowledge on the epidemiology, etiopathogenesis, [...] Read more.
Pyogenic granuloma (PG) is a benign vascular lesion found predominantly in the oral cavity. Characterized by rapid growth and propensity to bleed, PG presents diagnostic challenges due to its similarity and alarming proliferation. This narrative review synthesizes current knowledge on the epidemiology, etiopathogenesis, clinical manifestations, and management of oral PG, with emphasis on recent advances in diagnostic and therapeutic approaches. The epidemiology of the injury is meticulously analyzed, revealing a higher incidence in women and a wide range of ages of onset. It delves into the etiopathogenesis, highlighting the uncertainty surrounding the exact causal factors, although historical attributions suggest an infectious origin. It exhaustively analyzes the clinical and histopathological aspects of oral PG, offering information on its various presentations and the importance of an accurate diagnosis to guide effective treatment. It details treatment strategies, emphasizing the personalized approach based on individual patient characteristics. This comprehensive review consolidates current knowledge on oral PG, highlighting the need for further research to clarify its pathogenesis and optimize treatment protocols. Full article
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