Cellular and Molecular Mechanisms of Autoimmune Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 1333
Special Issue Editor
Interests: lysosomal storage disorders; vesicular trafficking; endosomal sorting; lysosome biogenesis; mitochondrial diseases; autoimmune disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases are characterized by an impaired self-tolerance and by pathogenic antibodies against normal tissue proteins. These autoantibodies can directly damage their target tissues, or they can induce aberrant downstream effects, e.g., by stimulating signaling molecules. Various tissues such as the epidermis, thyroid, neuromuscular junction, myelinated nerves or the pancreas can be targets of such autoantibodies. Profound inflammation can be a result of autoimmunity, and the first line of treatment has traditionally been anti-inflammatory therapy with corticosteroids. However, more targeted therapies have started to emerge as our understanding of the molecular and cellular pathomechanisms is growing.
The purpose of this Special Issue is to highlight novel aspects of the cellular and molecular mechanisms of human autoimmune diseases. We encourage the submission of review articles and original research papers of any length. Our aim is to provide a comprehensive update on the pathomechanisms of autoimmune diseases at the cellular and molecular level.
Prof. Dr. Ritva Tikkanen
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune diseases
- self-tolerance
- immune cells
- autoantibodies
- autoantigens
- pathomechanisms
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