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Editorial Board Members’ Collection Series: Stem Cells and Regenerative Medicine
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Editorial Board Members’ Collection Series: Stem Cells and Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 4965

Special Issue Editors

Prof. Dr. Mark L. Weiss

E-Mail Website
Guest Editor
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Interests: regenerative therapy; stem cells; cell biology; mesenchymal stromal cells
Prof. Dr. Maciej Kurpisz

E-Mail Website
Guest Editor
Department of Reproductive Biology and Stem Cells, Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
Interests: stem cells; male infertility; human genetics; reproductive immunology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Alessandra Marconi

E-Mail Website
Guest Editor
DermoLab, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, 42124 Modena, Italy
Interests: cell biology; stem cells; 3D culture models; cell migration; cell adhesion; skin biology; cancer research; anti-cancer agents; translational medicine

Special Issue Information

Dear Colleagues,

Over the last decade, advances in stem cell biology have provided hope for the treatment of human diseases that cannot be cured with conventional medicines. Regenerative medicine is a broad field that includes the processes of replenishing human cells in tissues or organs to restore their normal functions. Therefore, tissue regeneration depends on a population of self-renewing stem cells and their integration into the appropriate tissue niche.

This Special Issue is open to all researchers studying stem cells and their potential therapeutic use at any level, such as the identification of key molecular signaling or clinical applications. We welcome novel works on stem cell biology, stem microenvironment, stem cell signals, tissue engineering technology allowing for ex vivo cell maintenance, and their clinical application. Furthermore, manuscripts introducing the latest progress, new challenges, and knowledge in the field of tissue regeneration are welcome.

Prof. Dr. Mark L. Weiss
Prof. Dr. Maciej Kurpisz
Prof. Dr. Alessandra Marconi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative medicine
  • niche
  • tissue engineering
  • cell signaling
  • differentiation
  • stem cells therapies
  • cell culture technologies

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Published Papers (3 papers)

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Research

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19 pages, 19243 KiB  
Article
Aspirin Stimulates the Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitro
by Sarah Funke, Paul Severin Wiggenhauser, Anna Grundmeier, Sara Taha, Benedikt Fuchs, Alexandra Birt, Konstantin Koban, Riccardo E. Giunta and Constanze Kuhlmann
Int. J. Mol. Sci. 2024, 25(14), 7690; https://doi.org/10.3390/ijms25147690 - 13 Jul 2024
Viewed by 1774
Abstract
This study investigates the impact of acetylsalicylic acid (ASA), also known as aspirin, on adipose tissue-derived stem cells (ASCs), aiming to elucidate its dose-dependent effects on morphology, viability, proliferation, and osteogenic differentiation. Isolated and characterized human ASCs were exposed to 0 µM, 100 [...] Read more.
This study investigates the impact of acetylsalicylic acid (ASA), also known as aspirin, on adipose tissue-derived stem cells (ASCs), aiming to elucidate its dose-dependent effects on morphology, viability, proliferation, and osteogenic differentiation. Isolated and characterized human ASCs were exposed to 0 µM, 100 µM, 200 µM, 400 µM, 800 µM, 1000 µM, 10,000 µM, and 16,000 µM of ASA in vitro. Cell morphology, viability, and proliferation were evaluated with fluorescent live/dead staining, alamarBlue viability reagent, and CyQUANT® cell proliferation assay, respectively. Osteogenic differentiation under stimulation with 400 µM or 1000 µM of ASA was assessed with alizarin red staining and qPCR of selected osteogenic differentiation markers (RUNX2, SPP1, ALPL, BGLAP) over a 3- and 21-day-period. ASA doses ≤ 1000 µM showed no significant impact on cell viability and proliferation. Live/dead staining revealed a visible reduction in viable cell confluency for ASA concentrations ≥ 1000 µM. Doses of 10,000 µM and 16,000 µM of ASA exhibited a strong cytotoxic and anti-proliferative effect in ASCs. Alizarin red staining revealed enhanced calcium accretion under the influence of ASA, which was macro- and microscopically visible and significant for 1000 µM of ASA (p = 0.0092) in quantification if compared to osteogenic differentiation without ASA addition over a 21-day-period. This enhancement correlated with a more pronounced upregulation of osteogenic markers under ASA exposure (ns). Our results indicate a stimulatory effect of 1000 µM of ASA on the osteogenic differentiation of ASCs. Further research is needed to elucidate the precise molecular mechanisms underlying this effect; however, this discovery suggests promising opportunities for enhancing bone tissue engineering with ASCs as cell source. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Stem Cells and Regenerative Medicine)
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Review

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22 pages, 993 KiB  
Review
Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges
by Riccardo Foti, Gabriele Storti, Marco Palmesano, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Giulio Cervelli, Bong Sung Kim, Augusto Orlandi and Valerio Cervelli
Int. J. Mol. Sci. 2024, 25(15), 8390; https://doi.org/10.3390/ijms25158390 - 1 Aug 2024
Viewed by 1773
Abstract
Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro [...] Read more.
Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro into cells from other germinal lineages, including endothelial cells and neurons. ADSCs have a wide range of clinical applications, from breast surgery to chronic wounds. Furthermore, they are a promising cell population for future tissue-engineering uses. Accumulating evidence indicates a decreased proliferation and differentiation potential of ADSCs with an increasing age, increasing body mass index, diabetes mellitus, metabolic syndrome, or exposure to radiotherapy. Therefore, the recent literature thoroughly investigates this cell population’s senescence mechanisms and how they can hinder its possible therapeutic applications. This review will discuss the biological mechanisms and the physio-pathological causes behind ADSC senescence and how they can impact cellular functionality. Moreover, we will examine the possible strategies to invert these processes, re-establishing the full regenerative potential of this progenitor population. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Stem Cells and Regenerative Medicine)
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Other

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10 pages, 2013 KiB  
Brief Report
Characterization of Skin Interfollicular Stem Cells and Early Transit Amplifying Cells during the Transition from Infants to Young Children
by Marika Quadri, Caroline Baudouin, Roberta Lotti, Elisabetta Palazzo, Letizia Campanini, François-Xavier Bernard, Gaëlle Bellemere, Carlo Pincelli and Alessandra Marconi
Int. J. Mol. Sci. 2024, 25(11), 5635; https://doi.org/10.3390/ijms25115635 - 22 May 2024
Viewed by 925
Abstract
In the interfollicular epidermis, keratinocyte stem cells (KSC) generate a short-lived population of transit amplifying (TA) cells that undergo terminal differentiation after several cell divisions. Recently, we isolated and characterized a highly proliferative keratinocyte cell population, named “early” TA (ETA) cell, representing the [...] Read more.
In the interfollicular epidermis, keratinocyte stem cells (KSC) generate a short-lived population of transit amplifying (TA) cells that undergo terminal differentiation after several cell divisions. Recently, we isolated and characterized a highly proliferative keratinocyte cell population, named “early” TA (ETA) cell, representing the first KSC progenitor with exclusive features. This work aims to evaluate epidermis, with a focus on KSC and ETA cells, during transition from infancy to childhood. Reconstructed human epidermis (RHE) generated from infant keratinocytes is more damaged by UV irradiation, as compared to RHE from young children. Moreover, the expression of several differentiation and barrier genes increases with age, while the expression of genes related to stemness is reduced from infancy to childhood. The proliferation rate of KSC and ETA cells is higher in cells derived from infants’ skin samples than of those derived from young children, as well as the capacity of forming colonies is more pronounced in KSC derived from infants than from young children’s skin samples. Finally, infants-KSC show the greatest regenerative capacity in skin equivalents, while young children ETA cells express higher levels of differentiation markers, as compared to infants-ETA. KSC and ETA cells undergo substantial changes during transition from infancy to childhood. The study presents a novel insight into pediatric skin, and sheds light on the correlation between age and structural maturation of the skin. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Stem Cells and Regenerative Medicine)
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