New Molecular Mechanisms and Advanced Therapies for Solid Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 6165
Special Issue Editor
Interests: cancer; kinase inhibitor; target therapy; signal transduction; cell cycle; mitogenesis; survival; resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Solid tumors account for approximately 90% of adult human cancers. The two main types of solid tumors are sarcomas and carcinomas.
The current most common solid tumors are breast cancer, lung cancer, prostate cancer, colon cancer and skin cancer.
Treatment for solid tumors generally combines several types of therapy, which can basically include surgery, chemotherapy, and radiation therapy. With the new understanding of the molecular mechanisms of solid tumor progression, leading to the evolution of many new therapeutic regimens and their subsequent trials, targeted drug therapy, immunotherapy and personalized medicines are now widely employed.
Current precision medicine for solid tumors includes a combination of appropriate cytotoxic agents and targeted drugs for each molecular subtype. Since molecular subtypes provide appropriate therapeutic targets, various molecular subtypes have been explored for gene mutation, gene expression, and protein expression. However, this tumor heterogeneity is considered to be one of the main reasons for chemoresistance, as refractory solid tumors exhibit very high tumor heterogeneity and fail to be eradicated even when treated with different anticancer drugs.
This Special Issue aims to provide a platform for the research on new molecular mechanisms in solid tumors, with particular attention to potential new targets and treatments and therefore to new pathogenetic pathways involved in these diseases. We welcome your submissions of original papers and updated review articles based on findings from a molecular point of view.
Prof. Dr. Valentina De Falco
Guest Editor
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Keywords
- solid tumor
- kinase inhibitors
- animal model
- cell culture
- drug resistance
- signal transduction
- survival
- cell reprogramming
- pathways
- clinical trials
- target therapy
- cell cycle
- cell death inhibiting
- oncogene
- precision medicine
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