Induction and Regulation of Autoimmunity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2018) | Viewed by 5514
Special Issue Editor
Interests: autoimmunity; targeted therapy; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases result from unabated immune responses to self-antigens following a break in immune tolerance leading to tissue dysfunction and damage. Both genetic and environmental factors are involved in the pathogenesis of autoimmunity. Several autoimmune diseases show an association with particular major histocompatibility complex (MHC) haplotypes. In addition, non-MHC genes have also been shown to influence susceptibility/resistance to autoimmunity. The environmental factors comprise diverse agents and stimuli, including external microbes, smoke and other toxic substances. The outcome of the interactions between genetic and environmental factors can be further modulated by stress. In addition, the impact of microbial flora and metabolic factors on autoimmune pathogenesis is becoming increasingly clear. The activity of pathogenic effector lymphoid cells can be controlled by a variety of regulatory T cells. Furthermore, some of the above-mentioned factors that are implicated in the induction of autoimmunity can, under different circumstances, also mediate regulatory activities, thus emphasizing the dual role of some of the mediators of autoimmunity. Strategies aimed at inhibiting the generation and expansion of pathogenic effector cells and/or enhancing the induction and activity of regulatory cells are being extensively pursued for the prevention and treatment of autoimmunity. Stem cell research is adding a new dimension to the therapeutic arsenal against these diseases. This Special Issue is devoted to the elaboration of cellular and molecular mechanisms underlying the induction and regulation of autoimmunity, as well as novel therapeutic approaches for the control of autoimmunity. Both original and review articles covering these aspects of autoimmunity are welcome.
Prof. Dr. Kamal D. Moudgil
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Autoantigens
- Autoantibodies
- Autoimmunity
- Immunoregulation
- Immunotherapy
- Major histocompatibility complex
- Metabolomics
- Microbial flora
- Regulatory cells
- Self-tolerance
- T helper cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
