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Novel Biomarkers in Cardiovascular Disease: From Bench to Bedside

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 3235

Special Issue Editors


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Guest Editor
Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany
Interests: acute coronary syndrome; interventional procedures and pharmacological therapy; reperfusion injury; arginine metabolism; endothelial biology; metabolism and regeneration; microcirculation; cardiogenic shock and heart failure
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Internal Medicine II, University Clinic Salzburg, Paracelsus Medical University Salzburg, Müllner Hauptstraße 48, 5020 Salzburg, Austria
Interests: biomarkers; myocardial ischemia; heart failure; HFpEF; microRNA; vascular/endothelial stress; atherosclerosis; valvular heart disease; risk assessment; mortality prediction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomarker diagnostics in diseases as myocardial infarction, heart failure, chronic kidney disease, and inflammatory conditions have proven to be of substantial help in the last couple of years. Biomarkers such as troponins (myocardial ischemia) and NT-proBNP (myocardial wall stress), interleukin-6 or procalcitonin in inflammatory diseases have shown great potential, though, they just cover aspects of the pathophysiological process. Research on novel biomarkers is important for a better understanding of multiple cellular pathways that are involved in these disease conditions. For example, when heart disease is accompanied by other pathophysiological entities such as arrhythmia, renal failure, diabetes, pulmonary hypertension, or COPD, risk assessment could become even more complicated. Further research on biomarkers could help identify those patients at higher risk, plan individualized treatments, and improve secondary prevention strategies.

This Special Issue is dedicated to all original research articles and reviews, exploring novel biomarkers in cardiovascular diseases, focus on therapeutic targets, pathological effects and signaling pathways. Purely clinical investigations are not suitable but clinical submissions with some component of deep molecular studies are quite welcome.

Prof. Dr. Christian Jung

Dr. Michael Lichtenauer

Guest Editors

 

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Keywords

  • troponins
  • NT-proBNP
  • interleukin-6
  • procalcitonin
  • heart failure

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Published Papers (1 paper)

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Research

18 pages, 4926 KiB  
Article
Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning
by Marta Consegal, Norberto Núñez, Ignasi Barba, Begoña Benito, Marisol Ruiz-Meana, Javier Inserte, Ignacio Ferreira-González and Antonio Rodríguez-Sinovas
Int. J. Mol. Sci. 2021, 22(8), 4151; https://doi.org/10.3390/ijms22084151 - 16 Apr 2021
Cited by 13 | Viewed by 2518
Abstract
Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH inhibition is additive to that of remote ischemic perconditioning (RIC) in pigs [...] Read more.
Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH inhibition is additive to that of remote ischemic perconditioning (RIC) in pigs submitted to transient coronary artery occlusion, and whether protective maneuvers influence plasma levels of citric acid cycle metabolites. Forty pigs were submitted to 40 min coronary occlusion and reperfusion, and allocated to four groups (controls, sodium malonate 10 mmol/L, RIC, and malonate + RIC). Plasma was obtained from femoral and great cardiac veins and analyzed by LC-MS/MS. Malonate, RIC, and malonate + RIC reduced infarct size (24.67 ± 5.98, 25.29 ± 3.92 and 29.83 ± 4.62% vs. 46.47 ± 4.49% in controls, p < 0.05), but no additive effects were detected. Enhanced concentrations of succinate, fumarate, malate and citrate were observed in controls during initial reperfusion in the great cardiac vein, and most were reduced by cardioprotective maneuvers. Concentrations of succinate, fumarate, and malate significantly correlated with infarct size. In conclusion, despite the combination of SDH inhibition during reperfusion and RIC did not result in additive protection, plasma concentrations of selected citric acid cycle metabolites are attenuated by protective maneuvers, correlate with irreversible injury, and might become a prognosis tool in STEMI patients. Full article
(This article belongs to the Special Issue Novel Biomarkers in Cardiovascular Disease: From Bench to Bedside)
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