Advances in Human Breath Molecular Profiling for Medical Diagnosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 3390
Special Issue Editors
2. Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
3. V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
Interests: liquid chromatography; mass spectrometry; climate change; spectroscopy; chromatography; sample preparation; proteins; molecular biology
Special Issues, Collections and Topics in MDPI journals
Interests: metabolomics; proteomics; lipidomics; mass-spectrometry; clinical mass spectrometry; high resolution mass-spectrometry; translational medicine
Special Issues, Collections and Topics in MDPI journals
2. Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
3. V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
Interests: mass spectrometry; chromatography; liquid chromatography; proteomics; systems biology; biochemistry; proteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human breath, along with urine and blood, has long been one of the three major biological media for assessing human health and environmental exposure. Exhaled breath contains thousands of potential biomarkers, many of which are relevant to the respiratory clinician and researcher. Although less common in comparison to contemporary bio-fluids analyses, breath has become an attractive diagnostic medium as sampling is non-invasive. Over the past 20 years, breath research has made many advances in assessing health state, especially for new potential biomarkers for diseases such as lung cancer, chronic obstructive pulmonary disease (COPD), pneumonia and others non respiratory diseases. Overcoming many of its initial challenges related to sampling and analysis the new advanced methods for breath molecular profiling are constantly developed. Mass spectrometry (MS) coupled to separation techniques such as gas/liquid chromatography (GC/LC) is the main tool in Omics studies (proteomics, metabolomics) and is the most powerful approach for breath research which ensures reliable identification and discovery of new substances and potential biomarkers. At the same time more portable online MS based methods such as SIFT MS, PTR-MS, ambient MS with direct breath ionization (SESI, EESI etc.) and ion mobility approaches such as FAIMS showed its potential for online breath molecular profiling and patients diagnostics. Also new spectroscopy based technologies which included Nuclear magnetic resonance (NMR) and optical/chemical/biosensors are developing for online/offline analysis of breath and its molecular profiling for clinical application.
The current issue is focused on methodological advances in breath molecular profiling for assessing health state and new potential biomarkers discovery for diseases such as lung cancer, chronic obstructive pulmonary disease (COPD), pneumonia and others non respiratory diseases. The special attention will be paid to studies of the breath research capabilities for monitoring of respiratory diseases associated with COVID-19.
With regards,
Dr. Alexey Koninikhin
Prof. E N Nikolaev
Dr. Vladimir Frankevich
Guest Editors
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Keywords
- Exhaled Breath Analysis
- Exhaled Breath Condensate (EBC)
- Mass-Spectrometry
- SIFT MS
- PTR-MS
- FAIMS
- Spectroscopy
- Biosensors
- NMR
- Omics
- Proteomics
- Metabolomics
- Respiratory Diseases
- Lung Cancer
- COPD
- Tuberculosis
- Pneumonia
- COVID-19
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