Frontiers in Cardiometabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 4495
Special Issue Editor
Interests: platelets function; nitric oxide; haemostasis; thrombosis; anti-platelet drugs; platelet dysfunction in metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiometabolic diseases are the result of a combination of unhealthy lifestyle and genetic factors that may lead to obesity, obesity-related euglycaemic insulin resistance, type 2 diabetes mellitus (T2DM), thus contributing to the development of cardiovascular disease (CVD). Together, these metabolic diseases are among the leading causes of death in westernized societies and frequently present themselves as comorbid conditions also for the presence of a prothrombotic tendency. An increased thrombotic tendency in these metabolic disorders stems from platelet hyperactivity, enhanced activity of prothrombotic coagulation factors and impaired fibrinolysis. Furthermore, a low-grade inflammatory response and increased oxidative stress accelerate the atherothrombosis process and result in premature and more severe cardiovascular disease.
This Special Issue is calling both original articles and reviews providing to the readers of IJMS a comprehensive elucidation about dysregulation of the cellular processes involved in the increased thrombotic risk in metabolic diseases characterized by obesity, dyslipidemia, hyperglycemia, and/or insulin resistance.
Dr. Isabella Russo
Guest Editor
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Keywords
- thrombosis
- platelets
- coagulation
- diabetes
- obesity
- insulin resistance
- metabolic disease
- cardiovascular diseases
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