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IJMS
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Endometrium and Pregnancy Immune Tolerance
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Endometrium and Pregnancy Immune Tolerance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 13165

Special Issue Editors

Dr. Kazuya Kusama

E-Mail Website
Guest Editor
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
Interests: endometrium; implantation; trophoblast; extracellular vesicle; endogenous retrovirus; decidualization; syncytialization; endometriosis; preeclampsia; innate immunity
Prof. Dr. Kazuhiro Tamura

E-Mail Website
Guest Editor
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
Interests: endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; senolysis; prostaglandin; inflammation; hypertensive disorders of pregnancy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pregnancy is a unique physiological process, and complicated interaction between the embryo and uterine endometrium is required for its establishment. During the implantation period from fertilization to embryo implantation to the endometrium, many pregnancy losses occur due possibly to insufficient communication between the blastocyst and the maternal endometrium. After embryo implantation, many factors, including immune abnormality, cause pregnancy complications, leading to preterm labor. Notably, immunologic tolerance to the fetal allograft must be established to permit embryo development and subsequent pregnancy maintenance.

This Special Issue is dedicated to all aspects of maternal pregnancy immune tolerance, including the immunology of pregnancy in health and disease. When considering your submission, please keep in mind that IJMS is a journal of molecular science, and so, pure clinical studies will not be suitable. However, submissions of clinical studies that include biomolecular experiments are welcomed.

Dr. Kazuya Kusama
Prof. Dr. Kazuhiro Tamura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrium
  • embryo implantation
  • immunotolerance
  • infertility
  • placentation
  • pregnancy complication
  • inflammation
  • preterm labor
  • sex hormone
  • maternal recognition of pregnancy

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Published Papers (3 papers)

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20 pages, 9441 KiB  
Article
Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization
by Zhuo Song, Bo Li, Meng-Yuan Li, Jia-Mei Luo, Yu-Qi Hong, Yu-Ying He, Si-Ting Chen, Zhen-Shan Yang, Chen Liang and Zeng-Ming Yang
Int. J. Mol. Sci. 2022, 23(7), 3699; https://doi.org/10.3390/ijms23073699 - 28 Mar 2022
Cited by 13 | Viewed by 2977
Abstract
Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In [...] Read more.
Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level in uterine stromal cells. Progesterone upregulates Caveolin-1 expression in luminal epithelium. During mouse in vitro decidualization, Caveolin-1 is significantly increased. However, Caveolin-1 is obviously decreased during human in vitro decidualization. Caveolin-1 overexpression and siRNA suppress and upregulate IGFBP1 expression under in vitro decidualization, respectively. Blastocysts-derived tumor necrosis factor α (TNFα) and human Chorionic Gonadotropin (hCG) regulate Caveolin-1 in mouse and human decidual cells, respectively. Caveolin-1 levels are also regulated by high glucose and insulin. In conclusion, a low level of Caveolin-1 should be beneficial for human decidualization. Full article
(This article belongs to the Special Issue Endometrium and Pregnancy Immune Tolerance)
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Review

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18 pages, 834 KiB  
Review
Endometrial Microbiota and Immune Tolerance in Pregnancy
by Annalisa Inversetti, Enrica Zambella, Alice Guarano, Marinella Dell’Avanzo and Nicoletta Di Simone
Int. J. Mol. Sci. 2023, 24(3), 2995; https://doi.org/10.3390/ijms24032995 - 3 Feb 2023
Cited by 20 | Viewed by 5204
Abstract
Recent studies have demonstrated that the uterus has its own microbiota. However, there is no consensus on endometrial microbiota composition, thus its role in the healthy uterine environment is still a frontier topic. Endometrial receptivity is key to embryo implantation, and in this [...] Read more.
Recent studies have demonstrated that the uterus has its own microbiota. However, there is no consensus on endometrial microbiota composition, thus its role in the healthy uterine environment is still a frontier topic. Endometrial receptivity is key to embryo implantation, and in this specific context immunological tolerance against fetal antigens and the tightly regulated expression of inflammatory mediators are fundamental. According to recent evidence, endometrial microbiota may interact in a very dynamic way with the immune system during the peri-conceptional stage and later during pregnancy. For this reason, a condition of dysbiosis might lead to adverse pregnancy outcomes. The aim of this review is to summarize the evidence on the molecular mechanisms by which the endometrial microbiota may interact with the immune system. For this purpose, the link between dysbiosis and reproductive disorders, such as infertility, recurrent pregnancy loss (RPL), and preterm birth, will be discussed. In conclusion, the most recent findings from molecular analyses will be reported to illustrate and possibly overcome the intrinsic limitations of uterine microbiota detection (low endometrial biomass, high risk of contamination during sampling, and lack of standardization). Full article
(This article belongs to the Special Issue Endometrium and Pregnancy Immune Tolerance)
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20 pages, 1581 KiB  
Review
Immune Tolerance of Embryo Implantation and Pregnancy: The Role of Human Decidual Stromal Cell- and Embryonic-Derived Extracellular Vesicles
by Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu and Chyong-Huey Lai
Int. J. Mol. Sci. 2022, 23(21), 13382; https://doi.org/10.3390/ijms232113382 - 2 Nov 2022
Cited by 19 | Viewed by 4200
Abstract
Embryo–endometrial communication plays a critical role in embryo implantation and the establishment of a successful pregnancy. Successful pregnancy outcomes involve maternal immune modulation during embryo implantation. The endometrium is usually primed and immunomodulated by steroid hormones and embryo signals for subsequent embryo implantation [...] Read more.
Embryo–endometrial communication plays a critical role in embryo implantation and the establishment of a successful pregnancy. Successful pregnancy outcomes involve maternal immune modulation during embryo implantation. The endometrium is usually primed and immunomodulated by steroid hormones and embryo signals for subsequent embryo implantation and the maintenance of pregnancy. The roles of extracellular vesicles (EVs) and microRNAs for the embryo–maternal interactions have been elucidated recently. New evidence shows that endometrial EVs and trophectoderm-originated EV cargo, including microRNAs, proteins, and lipids in the physiological microenvironment, regulate maternal immunomodulation for embryo implantation and subsequent pregnancy. On the other hand, trophoblast-derived EVs also control the cross-communication between the trophoblasts and immune cells. The exploration of EV functions and mechanisms in the processes of embryo implantation and pregnancy will shed light on a practical tool for the diagnostic or therapeutic approaches to reproductive medicine and infertility. Full article
(This article belongs to the Special Issue Endometrium and Pregnancy Immune Tolerance)
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