The Emerging Role of Extracellular Vesicles in Experimental Oncology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 15885
Special Issue Editors
Interests: oncology; ethics in oncology; palliative care in oncology; cancer-associated coagulation; extracellular vesicles; cancer cell resistance; cell signaling
Special Issues, Collections and Topics in MDPI journals
Interests: extracellular vesicles; microvesicles; plasma membrane; cancer cell resistance; extrinsic coagulation; high-resolution flow cytometry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs) are nonreplicating, lipid-bilayer-delimited particles that are released from almost all cells. Thanks to modern technologies such as differential centrifugation, high-resolution flow cytometry, precipitation of subgroups by magnetic beads and surface markers, different subgroups of EVs have been defined such as ectosomes/microvesicles/microparticles (plasma membrane origin), exosomes (endosomal origin), apoptotic bodies (formed by dying cells), large oncosomes, etc. Research in this area is not only of interest from the point view of biochemistry and biology but at the threshold of gaining clinical relevance, especially in inflammatory medicine and oncology. Particularly the latter is promising as we know now that tumor cells in an inflammatory environment (microenvironment) release a huge number of EVs. These can be isolated from virtually all body fluids and are about to be used in early detection, characterization, and therapy monitoring of malignant diseases.
Nevertheless, many questions are still open, such as:
- The appropriate and suitable isolation method of the EV subpopulation of interest;
- The target structures of potential clinical interest (e.g., encapsulated genetic material, surface markers and receptors, membrane components);
- The correlation with established clinical and pathological parameters;
- Differentiation between tumor- and host-derived EVs.
With this Special Issue named “The Emerging Role of EVs in Experimental Oncology”, we would like to contribute to this evolving and rapidly expanding field. If you work in this research area, we would be pleased to receive a contribution from you. Let us make this Special Issue forward-looking!
Prof. Dr. Frank Gieseler
Dr. Fanny Ender
Guest Editors
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