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Polymeric Nano-Biomaterials for Medical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 4988

Special Issue Editors


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Guest Editor
Engineering Research Centre for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Technology, Shanghai 200237, China
Interests: nano-biomaterials
Special Issues, Collections and Topics in MDPI journals
Institute of Translational Medicine, Shanghai University, Shanghai 200444, China
Interests: biomaterials; cancer immunotherapy; tissue regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to participate in the following Special Issue of International Journal of Molecular Sciences (IJMS) on “Polymeric Nano-Biomaterials for Medical Applications”, the details of which can be found below:

Special Issue: Polymeric Nano-Biomaterials for Medical Applications;       
Guest Editor: Dr. Yulin Li; Dr. Jie Gao
Deadline for manuscript submissions: 31 May 2022.

This Special Issue aims to focus on the current and future development of functional polymer nanomaterials for clinical transformation applications. Polymer nanomaterials are emerging nano-sized biomaterials with broad application potentials in medicine, due to features such as quantum size, surface and macroscopic quantum tunneling, which lead to good magnetic guidance targeting and biocompatibility. At present, nano polymers have been applied in immunoassays and interventional diagnosis and treatment and as carriers for the controlled release of drugs, growth factor and gene delivery. This issue will cover research on novel approaches for the development of advanced nano polymers and their specific applications in the field of biomedical science, such as drug/gene delivery, sensing, tissue engineering, etc.

Given your expertise on this topic and related disciplines, we would like to invite you and your colleagues to contribute to this Special Issue. The article may be either original research or a review (mini reviews are excluded). If you decide to contribute, please let us know, and send us your manuscript before the deadline. We also encourage authors to send us their tentative title and short abstract by e-mail ([email protected]) for approval by the Editorial Office. If you cannot meet the deadline, please feel free to contact us.

Prof. Dr. Yulin Li
Prof. Dr. Jie Gao
Guest Editors

Manuscript Submission Information

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Published Papers (1 paper)

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Research

17 pages, 4174 KiB  
Article
Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells
by Aleksandar Radivoievych, Benjamin Kolp, Sergii Grebinyk, Svitlana Prylutska, Uwe Ritter, Oliver Zolk, Jörn Glökler, Marcus Frohme and Anna Grebinyk
Int. J. Mol. Sci. 2023, 24(2), 1020; https://doi.org/10.3390/ijms24021020 - 5 Jan 2023
Cited by 7 | Viewed by 4181
Abstract
The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C [...] Read more.
The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C60), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT). For that purpose, we analyzed C60 effects on human cervix carcinoma HeLa cells in combination with a low-intensity US treatment. The time-dependent accumulation of C60 in HeLa cells reached its maximum at 24 h (800 ± 66 ng/106 cells). Half of extranuclear C60 is localized within mitochondria. The efficiency of the C60 nanostructure’s sonoexcitation with 1 MHz US was tested with cell-based assays. A significant proapoptotic sonotoxic effect of C60 was found for HeLa cells. C60′s ability to induce apoptosis of carcinoma cells after sonoexcitation with US provides a promising novel approach for cancer treatment. Full article
(This article belongs to the Special Issue Polymeric Nano-Biomaterials for Medical Applications)
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