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Advanced Strategies in Probiotic Approaches and Disease
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Advanced Strategies in Probiotic Approaches and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 11090

Special Issue Editor

Dr. Maria Santagati

E-Mail Website
Guest Editor
Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy
Interests: screening and characterization of probiotic strains including strains producing bacteriocins involved in antimicrobial activity; microbial genome analysis and microbiome studies; sequencing and characterization of mobile genetic elements responsible for antibiotic resistance and production of bacteriocin genes

Special Issue Information

Dear Colleagues,

The search for probiotic strains possessing innovative functional characteristics and their formulations has been evolving rapidly and could lead to innovative therapeutic strategies; this is also due to the propagation of antibiotic resistance genes and the spread of multidrug resistant pathogens. Probiotic strains are usually associated with their health-promoting effects in the host, both on direct interactions between cells and indirectly through their released metabolites modulating and improving the human microbiota. Overall, the beneficial probiotic activities include competitive exclusion, co-aggregation and production of antimicrobial compounds, such as lactic acid, bacteriocin-like substances and biosurfactants, all properties that interfere with pathogen growth. As well as probiotic strategies, more recently, the use of non-live microorganisms such as heat-killed probiotics, microbial extracts and cell-free supernatants, has been growing in interest for their applications in alternative strategies and eventual use in practice.

This Special Issue would cover all molecular aspects of research related topics for therapeutic probiotic strains, health-promoting effects of probiotics and new advances in probiotic strategies.

Dr. Maria Santagati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • bacteriocins
  • cell free supernatants (CFSs)
  • microbiome
  • antimicrobial activity
  • metabolites

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Published Papers (2 papers)

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Review

34 pages, 45281 KiB  
Review
Molecular and Cellular Mechanisms Influenced by Postbiotics
by Rafał Jastrząb, Damian Graczyk and Pawel Siedlecki
Int. J. Mol. Sci. 2021, 22(24), 13475; https://doi.org/10.3390/ijms222413475 - 15 Dec 2021
Cited by 32 | Viewed by 5840
Abstract
In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a plethora of functions, including the synthesis of bioactive [...] Read more.
In recent years, commensal bacteria colonizing the human body have been recognized as important determinants of health and multiple pathologic conditions. Among the most extensively studied commensal bacteria are the gut microbiota, which perform a plethora of functions, including the synthesis of bioactive products, metabolism of dietary compounds, and immunomodulation, both through attenuation and immunostimulation. An imbalance in the microbiota population, i.e., dysbiosis, has been linked to many human pathologies, including various cancer types and neurodegenerative diseases. Targeting gut microbiota and microbiome–host interactions resulting from probiotics, prebiotics, and postbiotics is a growing opportunity for the effective treatment of various diseases. As more research is being conducted, the microbiome field is shifting from simple descriptive analysis of commensal compositions to more molecular, cellular, and functional studies. Insight into these mechanisms is of paramount importance for understanding and modulating the effects that microbiota, probiotics, and their derivatives exert on host health. Full article
(This article belongs to the Special Issue Advanced Strategies in Probiotic Approaches and Disease)
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19 pages, 853 KiB  
Review
Short- and Long-Term Implications of Human Milk Microbiota on Maternal and Child Health
by María García-Ricobaraza, José Antonio García-Santos, Mireia Escudero-Marín, Estefanía Diéguez, Tomás Cerdó and Cristina Campoy
Int. J. Mol. Sci. 2021, 22(21), 11866; https://doi.org/10.3390/ijms222111866 - 1 Nov 2021
Cited by 11 | Viewed by 4587
Abstract
Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides [...] Read more.
Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides or polyamines, among others; in addition, HM has a “bifidogenic effect”, a prebiotic effect, as a result of the low concentration of proteins and phosphates, as well as the presence of lactoferrin, lactose, nucleotides and oligosaccharides. Recently, has been a growing interest in HM as a potential source of probiotics and commensal bacteria to the infant gut, which might, in turn, influence both the gut colonization and maturation of infant immune system. Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. Furthermore, we will summarize the current knowledge of how HM microbiota dysbiosis acts as a short- and long-term predictor of maternal and infant health. Finally, we also provide a critical view of the role of breast milk-related bacteria as a novel probiotic strategy in the prevention and treatment of maternal and offspring diseases. Full article
(This article belongs to the Special Issue Advanced Strategies in Probiotic Approaches and Disease)
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