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Role of Signaling Pathways in the Viral Life Cycle
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Role of Signaling Pathways in the Viral Life Cycle

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 12682

Special Issue Editor

Prof. Ugo Moens

E-Mail Website
Guest Editor
Faculty of Health Sciences, Institute of Medical Biology, University of Tromsø, NO-9037 Tromsø, Norway
Interests: polyomavirus; viral oncology; anti-viral therapy; replication; host interaction; DNA viruses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Signal transduction pathways control crucial cellular processes, including proliferation, differentiation, metabolism, gene expression, cell survival, and immune responses. Viruses are obligate intracellular parasites that hijack the host cell machinery for their own benefit. Therefore, it is not surprising that viruses manipulate signaling pathways to sustain different aspects of their life cycle such as viral genome replication, viral gene expression, controlling inflammation, and evading immune surveillance. Oncolytic viruses engage different signaling pathways to induce tumorigenesis by suppressing apoptosis, triggering cell cycle progression, affecting DNA damage response, and promoting angiogenesis and migration.

This Special Issue of the International Journal of Molecular Sciences focuses on how viruses exploit signaling pathways for their own purpose. This Special Issue accepts research articles, review articles, as well as short communications that highlight the role of signaling pathways in all aspects of the viral life cycle, but also how viruses manipulate signaling pathways to escape the immune system and to cause pathogenesis.

Prof. Ugo Moens
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • protein interaction
  • immune response
  • inflammation
  • oncogenesis
  • protein kinase
  • disease
  • RNA virus
  • DNA virus
  • signal transduction

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Published Papers (2 papers)

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Review

24 pages, 2700 KiB  
Review
The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection
by Nícia Rosário-Ferreira, António J. Preto, Rita Melo, Irina S. Moreira and Rui M. M. Brito
Int. J. Mol. Sci. 2020, 21(4), 1511; https://doi.org/10.3390/ijms21041511 - 22 Feb 2020
Cited by 43 | Viewed by 7372
Abstract
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according to the World [...] Read more.
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it according to the World Health Organization (WHO). Influenza viruses belong to the Orthomyxoviridae family and have a negative sense eight-segment single-stranded RNA genome that encodes 11 different proteins. The only control over influenza seasonal epidemic outbreaks around the world are vaccines, annually updated according to viral strains in circulation, but, because of high rates of mutation and recurrent genetic assortment, new viral strains of influenza are constantly emerging, increasing the likelihood of pandemics. Vaccination effectiveness is limited, calling for new preventive and therapeutic approaches and a better understanding of the virus–host interactions. In particular, grasping the role of influenza non-structural protein 1 (NS1) and related known interactions in the host cell is pivotal to better understand the mechanisms of virus infection and replication, and thus propose more effective antiviral approaches. In this review, we assess the structure of NS1, its dynamics, and multiple functions and interactions, to highlight the central role of this protein in viral biology and its potential use as an effective therapeutic target to tackle seasonal and pandemic influenza. Full article
(This article belongs to the Special Issue Role of Signaling Pathways in the Viral Life Cycle)
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34 pages, 1289 KiB  
Review
Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways
by Ugo Moens and Andrew Macdonald
Int. J. Mol. Sci. 2019, 20(16), 3914; https://doi.org/10.3390/ijms20163914 - 12 Aug 2019
Cited by 15 | Viewed by 4958
Abstract
Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or [...] Read more.
Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the infected cell into a tumor cell. One mechanism viruses employ to reprogram the host cell is through interference with signaling pathways. Polyomaviruses are naked, double-stranded DNA viruses whose genome encodes the regulatory proteins large T-antigen and small t-antigen, and structural proteins that form the capsid. The large T-antigens and small t-antigens can interfere with several host signaling pathways. In this case, we review the interplay between the large T-antigens and small t-antigens with host signaling pathways and the biological consequences of these interactions. Full article
(This article belongs to the Special Issue Role of Signaling Pathways in the Viral Life Cycle)
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