Cell Signaling Regulation in Extracellular Matrix
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 10488
Special Issue Editor
Interests: extracellular matrix; fibrosis; fibroblasts; heart; diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The extracellular matrix (ECM) is composed of an everchanging composite of glycoproteins, collagen types, proteoglycans, and glycosaminoglycans. These matrix proteins form the three-dimensional physical structure of the cell’s microenvironment. This diverse cluster of ECM proteins also imparts various biological functions through its ability to bind multiple interacting signaling molecules, such as other ECM proteins, growth factors, and adhesion receptors, to activate signaling pathways inducing cell growth, cell migration, proliferation, and gene expression. The ECM is also capable of transmitting mechanical forces throughout the tissue as well as to neighboring cells. This highly dynamic network must alter its composition and organization in order to meet the mechanical demands of tissues and organs. The ECM represents a key driver for mechanical and biochemical change as well as pathogenesis of multiple diseases throughout the body. A greater understanding of the molecular and cellular mechanisms responsible for pathophysiological changes is required to allow for development of effective therapies that specifically target ECM-cellular interactions.
This Special Issue aims to provide review and primary research articles focused on the cellular and molecular mechanisms of the ECM-cellular interactions in disease and the advancement of potential therapeutic interventions of these maladaptive processes.
We look forward to your contributions to this exciting Special Edition.
Dr. James A. Stewart
Guest Editor
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Keywords
- extracellular matrix (ECM)
- collagen
- proteoglycans
- glycoproteins
- adhesion receptors
- integrins
- growth factors
- growth factor receptors
- matrix metalloproteases (MMPs)
- fibroblasts
- myofibroblasts
- fibrosis
- signal regulation
- mechanical regulation
- microenvironment
- migration
- ECM remodeling
- pathogenesis
- tissue engineering
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