Targeting Stromal Cell Signaling within the Tumor Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 7282
Special Issue Editors
Interests: tumor microenvironment; cell–cell signaling; cell metabolism; hypoxia; oxidative stress; drug repurposing; ovarian cancer; breast cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Advances describing the interactions within cells in the tumor microenvironment (TME) have identified the dependencies of tumor cells on signaling arising from stromal cells within these tissues that are required for tumor development, progression, and resistance to standard therapeutic approaches. Preclinical studies demonstrate that targeting the stromal compartment within the TME may inhibit tumor cell self-renewal, proliferation, invasion, angiogenesis, immune evasion and other mechanisms involved in treatment resistance. There remains, however, an urgent need to further develop our understanding of the contribution of stromal cells to these important processes that are exploited by cancer cells which may define novel interactions that can be targeted using new or repurposed pharmacologic agents. In this Special Issue "Targeting Stromal Cell Signaling within the Tumor Microenvironment", we will highlight new research that elucidates the novel interactions within the TME, which may provide actionable mechanisms to exploit therapeutically, as well as discuss advances in preclinical therapeutic targeting of the TME, which may inform new approaches to improve patient outcomes.
This Special Issue is open to both original research manuscripts and review articles focusing on novel tumor–stromal signaling and advances in the preclinical evaluation of approaches to modulate the tumor microenvironment to improve therapeutic strategies.
Dr. Peter C. Hart
Dr. Michael Bradaric
Guest Editors
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Keywords
- fibroblast
- adipocyte
- endothelial cell
- macrophage
- t cell
- nk cell
- extracellular matrix
- extracellular vesicles
- cytokines
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