Novel Insights into Soft Tissue Sarcoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6163
Special Issue Editor
Special Issue Information
Dear Colleagues,
Soft tissue sarcomas (STSs) comprise 1% of adult malignant tumors (7% of childhood malignancies). Sarcomas encompass a heterogeneous group of malignancies of mesenchymal origin and may occur in any site of the body, which represents an additional challenge when it comes to therapy. They are a heterogeneous group of rare tumors, with more than 50 histological subtypes of STSs (WHO classification of tumors) having been identified, of which the most common in adults are malignant fibrous histiocytoma (28%), leiomyosarcoma (12%), liposarcoma (15%), synovial sarcoma (10%), and malignant peripheral nerve sheath tumors (6%). While the prognosis is good for patients diagnosed at an early stage and treated by adequate surgery, unresectable or metastatic diseases shrink the overall survival at 5 years to less than 10%, creating an unmet medical need.
The medical treatment of adult soft tissue sarcomas is more and more dictated by the histological subtype; this applies to both cytotoxic and target therapies. Anthracycline- and ifosfamide-based chemotherapies are the main therapeutic agents in the neoadjuvant, adjuvant, and metastatic adult-type STS disease settings, primarily for high-grade tumors, with the best-established response rates in adult soft tissue sarcomas for several years. In addition to this compound, there is evidence of efficacy of new drugs. Based on our current knowledge, 5–10% of all malignancies are part of hereditary cancer syndromes. Although the increasing diagnostic role of molecular genetic testing make us able to recognize more hereditary cancer patients, the careful exploration of family and clinical history by physicians is still the most important step for the diagnosis. Sarcomas are only 1% of all malignancies, but they often associate with familiar diseases so they can serve as an indicator of these syndromes. The diagnosis of hereditary cancer predisposition syndromes is essential to ensure appropriate therapy and follow-up for our patients. Multidisciplinary approach is mandatory in all cases (involving pathologist, radiologist, surgeons, radiation therapists, medical oncologists), and it should be carried out in reference centers for sarcomas.
Prof. Dr. Zsuzsanna Pápai
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
