Cellular Stress Response in Metabolic Syndrome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 6547
Special Issue Editor
Interests: ER stress; cellular stress; signaling pathways; autophagy; chaperone; apoptosis; mitochondria metabolism; functional Foods; inflammation; nutraceuticals; glucose metabolism; mTOR; PI3K
Special Issue Information
Dear Colleagues,
The trajectory of metabolic syndrome is determined by how cells respond to specific stress factors. These stress factors influence the form of response (adaptive/non-adaptive) to various pathological conditions, including diabetes, hepatic dysmetabolism, pancreatic disorder, and obesity. However, metabolic plasticity is largely driven by signaling networks that tune the cellular response. For instance, components of ER stress axis, such as IRE-α, PERK, ATF6, and ER-juxtaposed mitochondrial signaling, are emerging crucial hubs for autophagy, apoptosis, and energy metabolism with far-reaching implications on metabolic syndrome. ER and mitochondria are well-received key players in metabolism and are regulated by several molecular mechanisms. Therefore, regulators of ER stress and its associated metabolic stress could be targets for developing therapies against metabolic syndrome. However, the path to remedy is not possible without an in-depth understanding of molecular cues on cellular stress response in metabolic syndrome. Thus, this Special Issue aims to aggregate current breakthroughs and emerging novel concepts that drive a better understanding of metabolic syndrome, which could be applied to optimize cellular responses in order to treat metabolic syndrome.
Prof. Dr. Han-Jung Chae
Guest Editor
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Keywords
- metabolic syndrome
- metabolic plasticity
- cell response
- stress factors
- signaling networks
- ER stress
- mitochondrial signaling
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