Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration, 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1160

Special Issue Editor


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Guest Editor
IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy
Interests: neurodegenerative diseases; amyotrophic lateral sclerosis; multiple sclerosis; Parkinson's disease; Alzheimer's disease; Huntington's disease; multiple system atrophy; prion diseases; stroke
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue entitled “Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration, 2nd Edition”. In our previous Special Issue, entitled “Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration”, we collected high-quality papers covering a wide range of topics. This is a continuation of the previous series.

In recent decades, researchers have been trying to enhance the development of reliable biomarkers for neurodegenerative diseases, while medical practice has been moving toward precision medicine. However, there is still an urgent need to identify disease-specific biomarkers to improve early diagnostic workups, favor clinical classification and prognostic models, and facilitate the development of effective disease-modifying therapies. Most neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, have a late onset, meaning that, for each of these diseases, there are some factors which change as a person ages. One constant factor is that, in each disease, neurons gradually lose function as the disease progresses with age. About 20–40% of healthy people between 60 and 78 years of age experience discernable decrements in cognitive performance in several domains, including working, spatial, and episodic memory and processing speed.

This Special Issue aims to highlight current knowledge regarding neurodegeneration’s pathogenic mechanisms and underline possible current practices and future perspectives in neurodegenerative diseases.

In this Special Issue, original articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Lilla Bonanno
Guest Editor

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Keywords

  • neurodegenerative diseases
  • amyotrophic lateral sclerosis
  • multiple sclerosis
  • Parkinson's disease
  • Alzheimer's disease
  • Huntington's disease
  • multiple-system atrophy
  • prion diseases
  • stroke

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Published Papers (1 paper)

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Research

13 pages, 2278 KiB  
Article
Applications of Near Infrared Spectroscopy and Mirror Therapy for Upper Limb Rehabilitation in Post-Stroke Patients: A Brain Plasticity Pilot Study
by Caterina Formica, Simona De Salvo, Nunzio Muscarà, Lilla Bonanno, Francesca Antonia Arcadi, Viviana Lo Buono, Giuseppe Acri, Angelo Quartarone and Silvia Marino
J. Clin. Med. 2024, 13(21), 6612; https://doi.org/10.3390/jcm13216612 - 4 Nov 2024
Viewed by 961
Abstract
Objectives: The aim of this study was to identify the neural pattern activation during mirror therapy (MT) and explore any cortical reorganization and reducing asymmetry of hemispheric activity for upper limb rehabilitation in post-stroke patients. Methods: A box containing a mirror was placed [...] Read more.
Objectives: The aim of this study was to identify the neural pattern activation during mirror therapy (MT) and explore any cortical reorganization and reducing asymmetry of hemispheric activity for upper limb rehabilitation in post-stroke patients. Methods: A box containing a mirror was placed between the arms of the patients to create the illusion of normal motion in the affected limb by reflecting the image of the unaffected limb in motion. We measured the cerebral hemodynamic response using near-infrared spectroscopy (NIRS). We enrolled ten right-handed stroke patients. They observed healthy hand movements in the mirror (MT condition) while performing various tasks (MT condition), and then repeated the same tasks with the mirror covered (N-MT condition). Results: Significant activation of some brain areas was observed in the right and left hemiparesis groups for the MT condition, while lower levels of activation were observed for the N-MT condition. The results showed significant differences in hemodynamic response based on oxygenated (HbO) concentrations between MT and N-MT conditions across all tasks in sensorimotor areas. These neural circuits were activated despite the motor areas being affected by the brain injury, indicating that the reflection of movement in the mirror helped to activate them. Conclusions: These results suggest that MT promotes cortical activations of sensory motor areas in affected and non-affected brain sides in subacute post-stroke patients, and it encourages the use of these tools in clinical practice. Full article
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