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Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition
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Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 3248

Special Issue Editor

Dr. George K. Psillas

E-Mail Website
Guest Editor
1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, 546 36 Thessaloniki, Greece
Interests: hearing rehabilitation; middle and inner ear; ear surgery; cochlear implantation; auditory brainstem responses; facial nerve electrophysiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in the upcoming 3rd Edition of our Special Issue entitled "Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition". Building upon the resounding success of the previous two editions
[https://www.mdpi.com/journal/jcm/special_issues/hearing_disorders;
https://www.mdpi.com/journal/jcm/special_issues/EP71L3239L], this edition aims to continue fostering innovation and knowledge dissemination in this Hearing loss field.

Hearing loss represents one of the most wide-ranging disabilities, affecting more than 5% of the world's population. Different types of hearing loss, including conductive and sensorineural hearing loss, may lead to serious hearing impairments in children and adults. Diagnosis and management continue to be challenging for hearing disorders such as chronic otitis media, otosclerosis, cholesteatoma, congenital or acquired sensorineural hearing loss, sudden sensorineural hearing loss, autoimmune or metabolic hearing loss, and otogenic facial palsy. Electrophysiology and neuroscience approaches are needed to elucidate better the diagnostic dilemmas in the field of otology and neurotology. New treatment options will be discussed to improve potential methods of hearing restoration. We especially encourage submissions concerning hearing aids, cochlear/vestibular/auditory brainstem implantation, middle ear surgery, and stapedotomy.

Dr. George K. Psillas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • middle ear surgery
  • otosclerosis
  • sensorineural hearing loss
  • sudden hearing
  • cochlear implant

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Related Special Issue

Published Papers (4 papers)

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Research

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11 pages, 2056 KiB  
Article
Diagnosis of Enlarged Vestibular Aqueduct Using Wideband Tympanometry
by Akira Ganaha, Nao Nojiri, Takeshi Nakamura, Teruyuki Higa, Shunsuke Kondo and Tetsuya Tono
J. Clin. Med. 2024, 13(21), 6602; https://doi.org/10.3390/jcm13216602 - 3 Nov 2024
Viewed by 419
Abstract
Background: Wideband tympanometry (WBT) has the potential to distinguish various mechanical middle ear and inner ear pathologies noninvasively. This study investigated the diagnostic value of WBT in the diagnosis of enlarged vestibular aqueduct (EVA). Methods: The absorbance and resonance frequency (RF) of patients [...] Read more.
Background: Wideband tympanometry (WBT) has the potential to distinguish various mechanical middle ear and inner ear pathologies noninvasively. This study investigated the diagnostic value of WBT in the diagnosis of enlarged vestibular aqueduct (EVA). Methods: The absorbance and resonance frequency (RF) of patients with EVA (40 ears, 25 patients) and matched population controls (39 ears, 28 subjects) were compared, alongside receiver operating characteristic (ROC) analysis. Correlations between VA width and RF were also examined. Results: Patients with EVA had higher absorbance at low frequencies (226–917 Hz) and lower absorbance at high frequencies (2520–4896 Hz) compared to controls. The RF of the EVA group was significantly lower versus controls (751 [391–1165] vs. 933 [628–1346] Hz). The ROC analysis revealed area under the curve values of 0.771 and 0.801, respectively, for absorbance and RF. RF had a sensitivity, specificity, positive predictive value, and negative predictive value of 74.4%, 82.5%, 76.7%, and 80.6%, respectively, for diagnosing EVA. In the EVA group, the VA midpoint width (r = −0.334) and VA petrous width (r = −0.402) both significantly correlated with RF. Conclusions: Our findings support the utility of WBT for diagnosing EVA, with RF as the optimal index used. Full article
(This article belongs to the Special Issue Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition)
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13 pages, 2085 KiB  
Article
Evaluating Wideband Tympanometry Absorbance Changes in Cochlear Implant Recipients: Mechanical Insights and Influencing Parameters
by Rahel Bertschinger, Christian von Mitzlaff, Marlies Geys, Ahmet Kunut, Ivo Dobrev, Dorothe Veraguth, Christof Röösli, Alexander Huber and Adrian Dalbert
J. Clin. Med. 2024, 13(17), 5128; https://doi.org/10.3390/jcm13175128 - 29 Aug 2024
Viewed by 815
Abstract
Background: Cochlear implant (CI) electrode insertion can change the mechanical state of the ear whereby wideband tympanometry absorbance (WBTA) may serve as a sensitive tool to monitor these mechanical changes of the peripheral auditory pathway after CI surgery. In WBTA, the amount [...] Read more.
Background: Cochlear implant (CI) electrode insertion can change the mechanical state of the ear whereby wideband tympanometry absorbance (WBTA) may serve as a sensitive tool to monitor these mechanical changes of the peripheral auditory pathway after CI surgery. In WBTA, the amount of acoustic energy reflected by the tympanic membrane is assessed over a wide frequency range from 226 Hz to 8000 Hz. The objective of this study was to monitor changes in WBTA in CI recipients before and after surgery. Methods: Following otoscopy, WBTA measurements were conducted twice in both ears of 38 standard CI recipients before and in the range of 4 to 15 weeks after CI implantation. Changes from pre- to postoperative absorbance patterns were compared for the implanted as well as the contralateral control ear for six different frequencies (500 Hz, 750 Hz, 1000 Hz, 2000 Hz, 3000 Hz, 4000 Hz). Furthermore, the influence of the time point of the measurement, surgical access, electrode type, sex and side of the implantation were assessed for the implanted and the control ear in a linear mixed model. Results: A significant decrease in WBTA could be observed in the implanted ear when compared with the contralateral control ear for 750 Hz (p < 0.01) and 1000 Hz (p < 0.05). The typical two-peak pattern of WBTA measurements was seen in both ears preoperatively but changed to a one-peak pattern in the newly implanted ear. The linear mixed model showed that not only the cochlear implantation in general but also the insertion through the round window compared to the cochleostomy leads to a decreased absorbance at 750 and 1000 Hz. Conclusions: With WBTA, we were able to detect mechanical changes of the acoustical pathway after CI surgery. The implantation of a CI led to decreased absorbance in the lower frequencies and the two-peak pattern was shifted to a one-peak pattern. The result of the linear mixed model indicates that WBTA can detect mechanical changes due to cochlear implantation not only in the middle ear but also in the inner ear. Full article
(This article belongs to the Special Issue Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition)
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10 pages, 806 KiB  
Article
P1 and N1 Characteristics in Individuals with Normal Hearing and Hearing Loss, and Cochlear Implant Users: A Pilot Study
by Hye Yoon Seol, Soojin Kang, Sungkean Kim, Jihoo Kim, Euijin Kim, Sung Hwa Hong and Il Joon Moon
J. Clin. Med. 2024, 13(16), 4941; https://doi.org/10.3390/jcm13164941 - 22 Aug 2024
Viewed by 749
Abstract
Background: It has been reported in many previous studies that the lack of auditory input due to hearing loss (HL) can induce changes in the brain. However, most of these studies have focused on individuals with pre-lingual HL and have predominantly compared the [...] Read more.
Background: It has been reported in many previous studies that the lack of auditory input due to hearing loss (HL) can induce changes in the brain. However, most of these studies have focused on individuals with pre-lingual HL and have predominantly compared the characteristics of those with normal hearing (NH) to cochlear implant (CI) users in children. This study examined the visual and auditory evoked potential characteristics in NH listeners, individuals with bilateral HL, and CI users, including those with single-sided deafness. Methods: A total of sixteen participants (seven NH listeners, four individuals with bilateral sensorineural HL, and five CI users) completed speech testing in quiet and noise and evoked potential testing. For speech testing, the Korean version of the Hearing in Noise Test was used to assess individuals’ speech understanding ability in quiet and in noise (noise from the front, +90 degrees, and −90 degrees). For evoked potential testing, visual and auditory (1000 Hz, /ba/, and /da/) evoked potentials were measured. Results: The results showed that CI users understood speech better than those with HL in all conditions except for the noise from +90 and −90 degrees. In the CI group, a decrease in P1 amplitudes was noted across all channels after implantation. The NH group exhibited the highest amplitudes, followed by the HL group, with the CI group (post-CI) showing the lowest amplitudes. In terms of auditory evoked potentials, the smallest amplitude was observed in the pre-CI condition regardless of the type of stimulus. Conclusions: To the best of our knowledge, this is the first study that examined visual and auditory evoked potentials based on various hearing profiles. The characteristics of evoked potentials varied across participant groups, and further studies with CI users are necessary, as there are significant challenges in collecting and analyzing evoked potentials due to artifact issues on the CI side. Full article
(This article belongs to the Special Issue Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition)
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Review

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9 pages, 372 KiB  
Review
Unilateral Hearing Loss and Auditory Asymmetry in Mitochondrial Disease: A Scoping Review
by Marianna Manuelli, Andrea Migliorelli, Chiara Bianchini, Francesco Stomeo, Stefano Pelucchi, Elisabetta Genovese, Daniele Monzani, Silvia Palma and Andrea Ciorba
J. Clin. Med. 2024, 13(17), 5044; https://doi.org/10.3390/jcm13175044 - 26 Aug 2024
Viewed by 832
Abstract
Background/Objectives: Mitochondrial transfer RNA mutations are one of the most important causes of hereditary hearing loss in humans. In most cases, its presentation is bilateral and symmetrical; however, there are numerous cases of single-sided presentation or asymmetrical onset described in the literature [...] Read more.
Background/Objectives: Mitochondrial transfer RNA mutations are one of the most important causes of hereditary hearing loss in humans. In most cases, its presentation is bilateral and symmetrical; however, there are numerous cases of single-sided presentation or asymmetrical onset described in the literature that may represent a diagnostic challenge. The aim of this review is to present the evidence of auditory asymmetry in mitochondrial diseases, highlighting the possible presence of cases with atypical presentation. Methods: A review of the English literature to date on hearing loss and mitochondrial diseases was performed using PubMed, Scopus, and Google Scholar databases. The literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines for scoping review. Results: A total of 10 full-text articles were included in this review, comprising 25 patients with single-sided or asymmetrical hearing loss associated with mitochondrial disease. Conclusions: Sensorineural hearing loss due to mitochondrial disease can represent a complex diagnostic challenge in cases of asymmetric or unilateral presentation. It is critical to recognize this clinical variant and to diagnose it in daily clinical practice. Full article
(This article belongs to the Special Issue Hearing Disorders: Diagnosis, Management, and Future Opportunities: 3rd Edition)
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