Submit to JCM Review for JCM Propose a Special Issue

Journal Menu

Journal Browser

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application

Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Related Special Issues
Published Papers

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (1 May 2022) | Viewed by 20523

Share This Special Issue

Special Issue Editor

Dr. Kana Fujikura

E-Mail Website
Guest Editor

Department of Radiology, Division of Cardiology, NYU School of Medicine, NYU Langone Health Center for Biomedical Imaging, New York, NY 10016, USA
Interests: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The depth of information that can be obtained from non-invasive cardiovascular imaging continues to expand. Increasing numbers of clinical decisions are being made without intervention given the various non-invasive cardiovascular imaging methods available. Each imaging modality assesses cardiovascular conditions from a particular perspective. The relatively new multimodality approach offers multiple perspectives and thus the possibility of a better understanding of disease status and processes.

This Special Issue invites the submission of manuscripts that discuss the role of all non-invasive cardiovascular imaging modalities in critical clinical decision making. Articles that discuss recent advancements in non-invasive cardiovascular imaging are also welcomed. The imaging methods include but are not limited to echocardiography (TTE and TEE), cardiac magnetic resonance imaging (CMR), cardiovascular computed tomography imaging (CCT), nuclear cardiology, and stress test with imaging. The multimodality approach to non-invasive cardiovascular imaging is encouraged. Reviews including meta-analytic approaches in non-invasive cardiovascular imaging are also welcomed.

Dr. Kana Fujikura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Echocardiography
Cardiovascular magnetic resonance imaging
Cardiovascular computed tomography imaging
Nuclear cardiology imaging
Stress test with imaging
Multimodality cardiovascular imaging
Cardiomyopathy
Coronary artery disease
Microvascular disease
Valvular heart disease

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issues

Published Papers (8 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

13 pages, 2489 KiB

Open AccessArticle

Evaluation of Right Ventricular Function and Myocardial Microstructure in Fetal Hypoplastic Left Heart Syndrome

by Jing Ma, Yaping Yuan, Li Zhang, Shizhen Chen, Haiyan Cao, Liu Hong, Juanjuan Liu, Xiaoyan Song, Jiawei Shi, Yi Zhang, Li Cui, Xin Zhou and Mingxing Xie

J. Clin. Med. 2022, 11(15), 4456; https://doi.org/10.3390/jcm11154456 - 30 Jul 2022

Cited by 4 | Viewed by 1918

Abstract

Right ventricular (RV) function is one of the critical factors affecting the prognosis of fetuses with hypoplastic left heart syndrome (HLHS). Our study objectives included assessment of cardiac function and comprehensive measurement of cardiac microstructure. We retrospectively studied 42 fetuses diagnosed as HLHS by echocardiography. Myocardial deformation of the right ventricular wall was calculated automatically in offline software. Postmortem cardiac imaging for three control fetal hearts and four HLHS specimens was performed by a 9.4T DTI scanner. Myocardial deformation parameters of the RV (including strain, strain rate, and velocity) were significantly lower in HLHS fetuses (all p < 0.01). FA values increased (0.18 ± 0.01 vs. 0.21 ± 0.02; p < 0.01) in HLHS fetuses, but MD reduced (1.3 ± 0.15 vs. 0.88 ± 0.13; p < 0.001). The HLHS fetuses’ RV lateral base wall (−7.31 ± 51.91 vs. −6.85 ± 31.34; p = 0.25), middle wall (1.71 ± 50.92 vs. −9.38 ± 28.18; p < 0.001), and apical wall (−6.19 ± 46.61 vs. −11.16 ± 29.86, p < 0.001) had HA gradient ascent but HA gradient descent in the anteroseptal wall (p < 0.001) and inferoseptal wall (p < 0.001). RV basal lateral wall HA degrees were correlated with RVGLS (R² = 0.97, p = 0.02). MD values were positively correlated with RVGLS (R² = 0.93, p = 0.04). Our study found morphological and functional changes of the RV in HLHS fetuses, and cardiac function was related to the orientation patterns of myocardial fibers. It may provide insight into understanding the underlying mechanisms of impaired RV performance in HLHS. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

13 pages, 3315 KiB

Open AccessArticle

Decreased Left Atrial Reservoir Strain Is Associated with Adverse Outcomes in Restrictive Cardiomyopathy

by Jadranka Stojanovska, Nevriye Topaloglu, Kana Fujikura, Behnaz Khazai, El-Sayed Ibrahim, Alex Tsodikov, Nicole M. Bhave and Theodore J. Kolias

J. Clin. Med. 2022, 11(14), 4116; https://doi.org/10.3390/jcm11144116 - 15 Jul 2022

Cited by 3 | Viewed by 1738

Abstract

Background: Restrictive cardiomyopathy (RCM) places patients at high risk for adverse events. In this study, we aim to evaluate the association between left atrial function and time to adverse events such as all-cause mortality and cardiovascular hospitalizations related to RCM. Material and Methods: In this single-center study, ninety-eight patients with a clinical diagnosis of RCM were recruited from our registry: 30 women (31%); age (mean ± standard deviation) 61 ± 13 years. These patients underwent cardiac magnetic resonance (CMR) imaging from May 2007 to September 2015. Left atrial (LA) function (reservoir, contractile, and conduit strain), LA diameter and area, and left ventricular function (global longitudinal strain, ejection fraction), and volume were quantified, and the presence of late gadolinium enhancement was visually assessed. The cutoff value of the LA reservoir strain was selected based on tertile. An adjusted Cox proportional regression analysis was used to assess time to adverse outcomes with a median follow up of 49 months. Results: In our cohort, all-cause mortality was 36% (35/98). Composite events (all-cause mortality and cardiovascular hospitalizations) occurred in 56% of patients (55/98). All-cause mortality and composite events were significantly associated with a decreased LA reservoir strain (adjusted hazard ratio (aHR) = 0.957, p = 0.002 and aHR = 0.969, p = 0.008) using a stepwise elimination of imaging variables, demographics, and comorbidities. All-cause mortality and composite events were six and almost four times higher, respectively, in patients with the LA reservoir strain <15% (aHR = 5.971, p = 0.005, and HR = 4.252, p = 0.001) compared to patients with the LA reservoir strain >34%. Survival was significantly reduced in patients with an LA reservoir strain <15% (p = 0.008). Conclusions: The decreased LA reservoir strain is independently associated with time to adverse events in patients with RCM. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

10 pages, 612 KiB

Open AccessCommunication

Remodeling of Retinal Arterioles and Carotid Arteries in Heart Failure Development—A Preliminary Study

by Janusz Sadowski, Ryszard Targonski, Piotr Cyganski, Paulina Nowek, Magdalena Starek-Stelmaszczyk, Katarzyna Zajac, Judyta Juranek, Joanna Wojtkiewicz and Andrzej Rynkiewicz

J. Clin. Med. 2022, 11(13), 3721; https://doi.org/10.3390/jcm11133721 - 27 Jun 2022

Cited by 3 | Viewed by 1714

Abstract

Current data indicate that heart failure (HF) is associated with inflammation and microvascular dysfunction and remodeling. These mechanisms could be involved in HF development and progression, especially in HF with preserved ejection fraction (HFpEF). We aimed to compare structural changes in retinal arterioles and carotid arteries between HF patients and patients without heart failure. This preliminary, retrospective, case-control study included 28 participants (14 patients with HFpEF and 14 age- and sex-matched healthy controls). Carotid intima-media thickness to lumen ratio (cIMTLR) was assessed using B-mode ultrasonography. Retinal arterioles wall- to-lumen ratio (rWLR) was assessed by adaptive optics camera rtx1. The HF patients had higher IMTLR (Δ_median [HFpEF–control group] 0.07, p = 0.01) and eWLR (Δ_median 0.03, p = 0.001) in comparison to patients without HF. In the whole study group, rWLR correlated significantly with IMTLR (r = 0.739, p = 0.001). Prevalence of arterial hypertension was similar in both groups, however, patients with HF had a significantly lower office, central and 24-h ambulatory blood pressure (systolic Δ_median −21 to −18 mmHg; diastolic Δ_median −23 to −10 mmHg). Our data suggests gradual and simultaneous progression of vascular remodeling in both retinal arterioles and carotid arteries in HFpEF patients. This process could be a marker of HF development. Significantly lower blood pressure values in HF group may indicate that vascular remodeling could be independent of BP control. Nevertheless, further and larger prospective studies allowing to reduce the impact of confounding and address temporality are warranted. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

11 pages, 1128 KiB

Open AccessArticle

Pericardial Effusion on MRI in Autosomal Dominant Polycystic Kidney Disease

by Jin Liu, Kana Fujikura, Hreedi Dev, Sadjad Riyahi, Jon Blumenfeld, Jiwon Kim, Hanna Rennert and Martin R. Prince

J. Clin. Med. 2022, 11(4), 1127; https://doi.org/10.3390/jcm11041127 - 21 Feb 2022

Cited by 12 | Viewed by 2423

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiac abnormalities including mitral valve prolapse and aneurysmal dilatation of the aortic root. Herein, we investigated the potential association of pericardial effusion with ADPKD. Subjects with ADPKD (n = 117) and control subjects without ADPKD matched for age, gender and renal function (n = 117) undergoing MRI including ECG-gated cine MRI of the aorta and heart were evaluated for pericardial effusion independently by three observers measuring the maximum pericardial effusion thickness in diastole using electronic calipers. Pericardial effusion thickness was larger in ADPKD subjects compared to matched controls (Mann–Whitney p = 0.001) with pericardial effusion thickness >5 mm observed in 24 of 117 (21%) ADPKD subjects compared to 4 of 117 (3%) controls (p = 0.00006). Pericardial effusion thickness in ADPKD was associated with female gender patients (1.2 mm greater than in males, p = 0.03) and pleural effusion thickness (p < 0.001) in multivariate analyses. No subjects exhibited symptoms related to pericardial effusion or required pericardiocentesis. In conclusion, pericardial effusion appears to be more prevalent in ADPKD compared to controls. Although in this retrospective cross-sectional study we did not identify clinical significance, future investigations of pericardial effusion in ADPKD subjects may help to more fully understand its role in this disease. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

16 pages, 6692 KiB

Open AccessArticle

Early N-Terminal Pro B-Type Natriuretic Peptide (NTproBNP) Plasma Values and Associations with Patent Ductus Arteriosus Closure and Treatment—An Echocardiography Study of Extremely Preterm Infants

by Anna Gudmundsdottir, Marco Bartocci, Oda Picard, Joanna Ekström, Alexander Chakhunashvili, Kajsa Bohlin, Caroline Attner, Gordana Printz, Mathias Karlsson, Lilly-Ann Mohlkert, Jonna Karlén, Cecilia Pegelow Halvorsen and Anna-Karin Edstedt Bonamy

J. Clin. Med. 2022, 11(3), 667; https://doi.org/10.3390/jcm11030667 - 27 Jan 2022

Cited by 2 | Viewed by 2252

Abstract

The aim was to investigate the association of gestational age (GA), echocardiographic markers and levels of plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) with the closure rate of a haemodynamically significant patent ductus arteriosus (hsPDA). Ninety-eight Swedish extremely preterm infants, mean GA 25.7 weeks (standard deviation 1.3), born in 2012–2014, were assessed with echocardiography and for levels of NTproBNP. Thirty-three (34%) infants had spontaneous ductal closure within three weeks of age. Infants having spontaneous closure at seven days or less had significantly lower NTproBNP levels on day three, median 1810 ng/L (IQR 1760–6000 ng/L) compared with: infants closing spontaneously later, 10,900 ng/L (6120–19,200 ng/L); infants treated either with ibuprofen only, 14,600 ng/L (7740–28,100 ng/L); or surgery, 32,300 ng/L (29,100–35,000 ng/L). Infants receiving PDA surgery later had significantly higher NTproBNP values on day three than other infants. Day three NTproBNP cut-off values of 15,001–18,000 ng/L, predicted later PDA surgery, with an area under the curve in ROC analysis of 0.69 (0.54–0.83). In conclusion, the spontaneous PDA closure rate is relatively high in extremely preterm infants. Early NTproBNP levels can be used with GA in the management decisions of hsPDA. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

16 pages, 1219 KiB

Open AccessArticle

Stress Echocardiography Protocol for Deciding Type of Surgery in Ischemic Mitral Regurgitation: Predictors of Mitral Regurgitation Recurrence following CABG Alone

by Radoslaw Piatkowski, Janusz Kochanowski, Monika Budnik, Michal Peller, Marcin Grabowski and Grzegorz Opolski

J. Clin. Med. 2021, 10(21), 4816; https://doi.org/10.3390/jcm10214816 - 20 Oct 2021

Cited by 1 | Viewed by 2126

Abstract

Purpose: Although coronary artery bypass grafting alone (CABGa), or, with mitral annuloplasty (CABGmp), is considered the best therapeutic strategy for patients with ischemic mitral regurgitation (IMR), some recurrences are still reported. The aim of this study was to evaluate the use of the mitral deformation indices (MDI) as a predictor of recurrence of mitral regurgitation in a 12-month follow-up after CABG alone. Methods: A total of 145 patients after myocardial infarction with significant IMR, eligible for CABG, were prospectively enrolled in the study. Mitral valve morphology, left ventricle function, IMR degree as assessed by effective regurgitation orifice area (ERO), myocardial viability, and MDI were assessed prior to surgery. Patients were referred for CABGa (gr.1; n = 90) or CABGmp (gr.2; n = 55) based on clinical assessment, and the results of rest and stress echocardiography (exercise echocardiography and low dose dobutamine echocardiography-DBX). One year after surgery, each patient underwent the evaluation of cardiovascular events. Univariable logistic regression analysis was used to identify the factors of recurrence of IMR in 1 year follow-up. Serial echo examinations were performed in all patients at discharge, and at 1 and 12 months after surgery. Results: Logistic regression analysis revealed that in CABGa, group preoperative changes of tenting area (TA) and coaptation high (CH) during DBX remained the predictors of the recurrence of IMR in 12 months follow-up. TAdbx > 1 cm² provided a sensitivity of 90% and specificity of 29%, (AUC 0.6436). The best cut-off value for CHdbx was 0.4 cm (sensitivity 90%, specificity 34%; AUC 0.6432). In both groups (CABGa vs. CABGmp) no significant differences were observed in 12-month mortality (1.2% vs. 0%; p = 1.0), hospitalizations due to the heart failure (HF) exacerbation (5.9% vs. 8.5%; p = 0.72), and in the incidence of the composite endpoint (deaths/CV hosp/stroke) (7% vs. 8.5%; p = 0.742). Conclusions: The preoperative assessment of MDI changes during dbx can be used to identify patients with IMR qualified to CABG alone at increased risk of recurrence of IMR in 1 year follow-up. Mitral deformation analysis should be used for a better qualification of patients with IMR to the exact surgical approach. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

10 pages, 3223 KiB

Open AccessArticle

Speckle-Tracking Echocardiography with Novel Imaging Technique of Higher Frame Rate

by Kana Fujikura, Mohammed Makkiya, Muhammad Farooq, Yun Xing, Wayne Humphrey, Mohammad Hashim Mustehsan, Mario J. Garcia and Cynthia C. Taub

J. Clin. Med. 2021, 10(10), 2095; https://doi.org/10.3390/jcm10102095 - 13 May 2021

Cited by 6 | Viewed by 5006

Abstract

Background: The accuracy of speckle-tracking echocardiography (STE) depends on temporal resolution. The goal of this study was to demonstrate the feasibility of relatively high frame rate (rHi-FR) (~200 fps) for STE. Methods: In this prospective study, echocardiographic images were acquired using clinical scanners on patients with normal left ventricular systolic function using rHi-FR and conventional frame rate (Reg-FR) (~50 FPS). GLS values were evaluated on apical 4-, 2- and 3-chamber images acquired in both rHi-FR and Reg-FR. Inter-observer and intra-observer variabilities were assessed in rHi-FR and Reg-FR. Results: There were 143 echocardiograms evaluated in this study. The frame rate of rHi-FR was 190 ± 25 and Reg-FR was 50 ± 3, and the heart rate was 71 ± 13. Absolute strain values measured in rHi-FR were significantly higher than those measured in Reg-FR (all p < 0.001). Inter-observer and intra-observer correlations were strong in both rHi-FR and Reg-FR. Conclusions: We demonstrated that absolute strain values were significantly higher using rHi-FR when compared with Reg-FR. It is plausible that higher temporal resolution enabled the measurement of myocardial strain at desired time point. Further investigations are necessary to evaluate the value of rHi-FR to assess myocardial strain in the setting of tachycardia. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Figure 1

13 pages, 3779 KiB

Open AccessArticle

Towards an Enhanced Tool for Quantifying the Degree of LV Hyper-Trabeculation

by Gregorio Bernabé, José D. Casanova, Josefa González-Carrillo and Juan R. Gimeno-Blanes

J. Clin. Med. 2021, 10(3), 503; https://doi.org/10.3390/jcm10030503 - 1 Feb 2021

Cited by 4 | Viewed by 2016

Abstract

Left ventricular non-compaction (LVNC) is defined by an increase of trabeculations in left ventricular (LV) endomyocardium. Although LVNC can be in isolation, an increase in hypertrabeculation often accompanies genetic cardiomyopathies. Current methods for quantification of LV trabeculae have limitations. Several improvements are proposed and implemented to enhance a software tool to quantify the trabeculae degree in the LV myocardium in an accurate and automatic way for a population of patients with genetic cardiomyopathies (QLVTHCI). The software tool is developed and evaluated for a population of 59 patients (470 end-diastole cardiac magnetic resonance images). This tool produces volumes of the compact sector and the trabecular area, the proportion between these volumes, and the left ventricular and trabeculated masses. Substantial enhancements are obtained over the manual process performed by cardiologists, so saving important diagnosis time. The parallelization of the detection of the external layer is proposed to ensure real-time processing of a patient, obtaining speed-ups from 7.5 to 1500 with regard to QLVTHCI and the manual process used traditionally by cardiologists. Comparing the method proposed with the fractal proposal to differentiate LVNC and non-LVNC patients among 27 subjects with previously diagnosed cardiomyopathies, QLVTHCI presents a full diagnostic accuracy, while the fractal criteria achieve 78%. Moreover, QLTVHCI can be installed and integrated in hospitals on request, whereas the high cost of the license of the fractal method per year of this tool has prevented reproducibility by other medical centers. Full article

(This article belongs to the Special Issue Cardiovascular Imaging: Opportunities and Challenges in Clinical Application)

► Show Figures

Journal Menu

Journal Browser

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Related Special Issues

Published Papers (8 papers)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI