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Clinical Advances in Interstitial Lung Diseases
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Clinical Advances in Interstitial Lung Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 8707

Special Issue Editors

Dr. Yoshiaki Zaizen

E-Mail Website
Guest Editor
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
Interests: interstitial lung diseases; pulmonary medicine; diffuse lung disease; lung diseases; pulmonary fibrosis; tuberculosis
Special Issues, Collections and Topics in MDPI journals
Dr. Masaki Okamoto

E-Mail Website
Guest Editor
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
Interests: respirology; diffuse lung disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of interstitial lung disease has experienced significant progress over the past decade. The cryobiopsy method has been established as a method for obtaining tissue samples for the pathology. With the improvement of analysis technology using artificial intelligence, there have also been remarkable developments in genome classification. In pharmacological therapy, two antifibrotic agents, pirfenidone and nintedanib, have provided alternatives to conventional corticosteroid-based anti-inflammatory therapy and are effective in the treatment of idiopathic and progressive pulmonary fibrosis. Additionally, today, many compounds with antifibrotic activity are in development. Scientific evidence is also slowly but surely establishing non-pharmacological therapies, such as respiratory rehabilitation. We now need to understand the pathophysiology and prognoses of patients with interstitial lung disease and provide appropriate treatment and management.

In this Special Issue, we welcome authors to submit papers that will provide more reliable evidence of the advances in the diagnosis and treatment of interstitial lung disease.

You may choose our Joint Special Issue in Medicina.

Dr. Yoshiaki Zaizen
Dr. Masaki Okamoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interstitial lung disease
  • idiopathic interstitial pneumonias
  • idiopathic pulmonary fibrosis
  • hypersensitivity pneumonitis
  • connective tissue disease-associated interstitial lung disease
  • diagnosis
  • treatment

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Published Papers (4 papers)

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Research

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10 pages, 411 KiB  
Article
Does a Type of Inciting Antigen Correlate with the Presence of Lung Fibrosis in Patients with Hypersensitivity Pneumonitis?
by Kamila Deutsch, Katarzyna B. Lewandowska, Agata Kowalik, Iwona Bartoszuk, Piotr Radwan-Röhrenschef, Małgorzata Sobiecka, Małgorzata Dybowska, Witold Z. Tomkowski and Monika Szturmowicz
J. Clin. Med. 2024, 13(17), 5074; https://doi.org/10.3390/jcm13175074 - 27 Aug 2024
Viewed by 622
Abstract
Introduction: Hypersensitivity pneumonitis (HP) is an interstitial inflammatory lung disease that develops as a result of exposition to various, mostly organic antigens. In some patients, fibrotic HP is diagnosed. Factors predisposing to the development of fibrotic lung disease in HP patients are not [...] Read more.
Introduction: Hypersensitivity pneumonitis (HP) is an interstitial inflammatory lung disease that develops as a result of exposition to various, mostly organic antigens. In some patients, fibrotic HP is diagnosed. Factors predisposing to the development of fibrotic lung disease in HP patients are not well documented in the literature. The genetic susceptibility of the patient, type of inciting antigen, and type of exposure, as well as various demographic and clinical variables, may influence the fibrotic process. Aim: The aim of the present study was to investigate whether the type of inciting antigen increases the risk of fibrotic lung disease in HP patients. Methods: Clinical data of consecutive patients with HP diagnosed between 2019 and 2023 were retrospectively reviewed. The exposition to the inciting antigens was investigated by the standardized questionnaire. Recent HP classification into fibrotic (fHP) and non-fibrotic (non-fHP) types was applied. Results: Sixty-six patients diagnosed with HP were analyzed. All patients filled out the exposure questionnaire, and 62 (94%) reported at least one possible exposure. The most prevalent exposures reported were avian, water systems, feather duvets, and hay/straw. Exposure to avian antigens as well as to coal/biomass heating were significantly more prevalent among patients with fHP compared to those with non-fHP (70% vs. 40%, p = 0.03 and 27% vs. 5%, p = 0.04, respectively). Nevertheless, in the multivariate analysis, older age at diagnosis was the only factor influencing the development of fHP (OR 1.064, 95% CI 1.004 to 1.138, p = 0.04). Reported avian antigen exposure correlated well with positive precipitins to avian antigens, whereas no correlation was found between hay/straw exposure and positive antibodies to termophilic actinomycetes. Conclusions: Exposure to birds and coal heating was the most frequently present factor in subjects with fHP, but only older age at diagnosis remained a significant fHP predictor in the multifactor analysis. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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12 pages, 1784 KiB  
Article
Usefulness of Combined Measurement of Surfactant Protein D, Thrombin–Antithrombin III Complex, D-Dimer, and Plasmin–α2 Plasmin Inhibitor Complex in Acute Exacerbation of Interstitial Lung Disease: A Retrospective Cohort Study
by Yuichiro Takeshita, Masako To, Yusuke Kurosawa, Naho Furusho, Toru Kinouchi, Kenji Tsushima, Yuji Tada, Yasuo To and Seiichiro Sakao
J. Clin. Med. 2024, 13(8), 2427; https://doi.org/10.3390/jcm13082427 - 21 Apr 2024
Cited by 1 | Viewed by 1015
Abstract
Background/Objectives: The coagulation cascade due to tissue damage is considered to be one of the causes of poor prognostic outcomes in patients with acute exacerbations of interstitial lung disease (AE-ILD). This study aimed to confirm coagulopathy in AE-ILD by evaluating the differences [...] Read more.
Background/Objectives: The coagulation cascade due to tissue damage is considered to be one of the causes of poor prognostic outcomes in patients with acute exacerbations of interstitial lung disease (AE-ILD). This study aimed to confirm coagulopathy in AE-ILD by evaluating the differences in the clinical characteristics of coagulation/fibrinolysis markers between stable ILD and AE-ILD. Methods: Overall, 81 patients were enrolled in this retrospective study and categorized into the following two groups: a chronic ILD group comprising 63 outpatients and an acute ILD group comprising 18 inpatients diagnosed with AE-ILD. Serum markers, including thrombin–antithrombin III complex (TAT), D-dimer, plasmin–α2 plasmin inhibitor complex (PIC), and surfactant protein D (SP-D), were compared between the groups. Results: Among the 18 patients with acute ILD, 17 did not meet the International Society of Thrombosis and Hemostasis scoring system for disseminated intravascular coagulation. In acute ILD, the SP-D levels were statistically significantly positively correlated with TAT, D-dimer, and PIC levels, while the Krebs von den Lungen 6 (KL-6) levels showed no correlation with any of these coagulation/fibrinolytic markers. A positive correlation was observed between SP-D levels and TAT, D-dimer, and PIC levels in acute ILD. Serum TAT, D-dimer, and PIC all showed good area under the receiver operating characteristic (ROC) curve (AUC) values in ROC analysis for the diagnosis of acute ILD. Conclusions: In the clinical setting of AE-ILD, it may be important to focus not only on alveolar damage markers such as SP-D but also on coagulation/fibrinolytic markers including TAT, D-dimer, and PIC. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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14 pages, 1498 KiB  
Article
Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease
by Goushi Matama, Masaki Okamoto, Kiminori Fujimoto, Takeshi Johkoh, Masaki Tominaga, Hiroshi Mukae, Noriho Sakamoto, Kosaku Komiya, Kenji Umeki, Masamichi Komatsu, Yasuo Shimizu, Koichiro Takahashi, Saeko Tokisawa, Yoshiaki Zaizen, Norikazu Matsuo, Takashi Nouno, Shinjiro Kaieda, Hiroaki Ida, Kenji Izuhara and Tomoaki Hoshino
J. Clin. Med. 2023, 12(22), 7100; https://doi.org/10.3390/jcm12227100 - 15 Nov 2023
Cited by 1 | Viewed by 1812
Abstract
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without [...] Read more.
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without ILD, and 137 healthy controls (HC). All biomarkers were higher in RA-ILD than HC or RA without ILD. KL-6 accurately detected ILD in RA patients (area under curve [AUC] = 0.939) and moderately detected SP-D and monomeric and total periostin (AUC = 0.803, =0.767, =0.767, respectively). Monomeric and total periostin were negatively correlated with normal lung area and positively correlated with honeycombing, reticulation, fibrosis score, and the traction bronchiectasis grade but not inflammatory areas. Serum levels of SP-D, KL-6, and LDH did not correlate with the extent of those fibrotic areas on high-resolution CT. Serum monomeric and total periostin were higher in patients with RA-ILD with definite usual interstitial pneumonia pattern compared with other ILD patterns. Immunohistochemical analyses of biopsy or autopsy lung tissues from RA-ILD during the chronic phase and acute exacerbation showed that periostin was expressed in fibroblastic foci but not inflammatory or dense fibrosis lesions. Periostin is a potential biomarker for diagnosis, evaluating fibrosis, and deciding therapeutic strategies for patients with RA-ILD. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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Review

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25 pages, 2408 KiB  
Review
A Review of Myositis-Associated Interstitial Lung Disease
by Renuka Kannappan, Raagni Kumar, Kimberly Cichelli and Lawrence H. Brent
J. Clin. Med. 2024, 13(14), 4055; https://doi.org/10.3390/jcm13144055 - 11 Jul 2024
Cited by 1 | Viewed by 4622
Abstract
There is a well-established relationship between different subsets of idiopathic inflammatory myopathies (IIMs, myositis) and interstitial lung disease (ILD), with lung complications sometimes presenting prior to myopathic manifestations. The subtypes of myositis include those that are strongly associated with ILD, such as polymyositis [...] Read more.
There is a well-established relationship between different subsets of idiopathic inflammatory myopathies (IIMs, myositis) and interstitial lung disease (ILD), with lung complications sometimes presenting prior to myopathic manifestations. The subtypes of myositis include those that are strongly associated with ILD, such as polymyositis (PM) and dermatomyositis (DM). Research has shown that in certain patients, these can then be further divided into subtypes using myositis-specific antibodies (MSAs), which are specific for myositis, and myositis-associated antibodies (MAAs), which can be found in myositis in overlap syndromes with other connective tissue diseases (CTDs). Notably, certain MSAs and MAAs are associated with ILD in patients with myositis. The clinical presentations of ILD in patients with myositis can vary widely and can be insidious in onset and difficult to diagnose. As ILD can progress rapidly in some cases, it is essential that clinicians are able to identify and diagnose ILD in patients with myositis. For this reason, the aim of this review is to highlight the clinical features, diagnostic criteria, important histopathologic, laboratory, and radiographic features, and treatment modalities for those patients with myositis-associated ILD. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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