Current Developments in the Diagnosis of and Therapy for Respiratory Disease-Associated Pulmonary Hypertension

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2099

Special Issue Editor


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Guest Editor
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
Interests: respirology; diffuse lung disease
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Special Issue Information

Dear Colleagues,

Over last 20 years, advances in drug therapy strategies targeting prostaglandin I2 (PGI2), endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors have significantly improved prognosis in patients with pulmonary hypertension. Pulmonary hypertension caused by respiratory disease is classified into group 3 of the World Health Organization functional classification (WHO-FC). The major causative diseases of this disease are fibrosing interstitial lung disease, chronic obstructive pulmonary disease, or chronic pulmonary fibrosis and emphysema. The treatment utilized for pulmonary hypertension caused by respiratory disease has two major problems. First, detecting the development of pulmonary hypertension during the course of chronic respiratory disease is difficult and is often delayed. In addition, compared with pulmonary hypertension with other etiologies, vasodilator therapy is less effective and the risk of adverse events such as ventilation–perfusion mismatch is greater. On the other hand, the efficacy of inhaled treprostinil therapy for pulmonary with interstitial lung disease has been proven in a multicenter, randomized, doubleblind, placebo-controlled, 16-week trial (N Engl J Med. 2021; 384: 325–334).

This Special Issue aims to provide an open forum for those attempting to answer these questions, whether by reporting research or by providing comments for review articles. We look forward to receiving your submissions.

Dr. Masaki Okamoto
Guest Editor

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Keywords

  • pulmonary hypertension
  • interstitial lung disease
  • chronic obstructive pulmonary disease
  • chronic pulmonary fibrosis and emphysema
  • vasodilator
  • hemodynamics

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Published Papers (1 paper)

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Review

19 pages, 3469 KiB  
Review
Unmasking a Silent Threat: Improving Pulmonary Hypertension Screening Methods for Interstitial Lung Disease Patients
by Vaida Averjanovaitė, Lina Gumbienė, Ingrida Zeleckienė and Virginija Šileikienė
Medicina 2024, 60(1), 58; https://doi.org/10.3390/medicina60010058 - 28 Dec 2023
Cited by 1 | Viewed by 1764
Abstract
This article provides a comprehensive overview of the latest literature on the diagnostics and treatment of pulmonary hypertension (PH) associated with interstitial lung disease (ILD). Heightened suspicion for PH arises when the advancement of dyspnoea in ILD patients diverges from the expected pattern [...] Read more.
This article provides a comprehensive overview of the latest literature on the diagnostics and treatment of pulmonary hypertension (PH) associated with interstitial lung disease (ILD). Heightened suspicion for PH arises when the advancement of dyspnoea in ILD patients diverges from the expected pattern of decline in pulmonary function parameters. The complexity of PH associated with ILD (PH-ILD) diagnostics is emphasized by the limitations of transthoracic echocardiography in the ILD population, necessitating the exploration of alternative diagnostic approaches. Cardiac magnetic resonance imaging (MRI) emerges as a promising tool, offering insights into hemodynamic parameters and providing valuable prognostic information. The potential of biomarkers, alongside pulmonary function and cardiopulmonary exercise tests, is explored for enhanced diagnostic and prognostic precision. While specific treatments for PH-ILD remain limited, recent studies on inhaled treprostinil provide new hope for improved patient outcomes. Full article
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