Microbiome-Gut-Brain Interactions in Health and Neurological Disorders
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 27071
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gut microbiota, as first speculated in 1885 by Louis Pasteur, plays a crucial role in human health and disease. The alterations in the composition of gut microbiota may cause the onset and the course of a number of human pathologies such as colorectal cancer, metabolic syndrome, obesity, allergies, inflammatory bowel disease, type 2 diabetes, and heart failure (Daliri et al., 2018). In the recent years, a growing number of evidence points to the relationship between the gut microbiota and the central nervous system, as the intestine and the brain can interact with each other through the nervous system or chemical substances crossing the blood-brain barrier. Indeed, the gut-brain interaction not only relies on the connection between intestinal neurons and the central nervous system mediated by the vagus nerve (Collins et al., 2012), but also on the action of substances produced by gut microbiota, immunological, neuroendocrine, and direct neural mechanisms that can influence brain activity, with possible repercussions on glial and neuronal function (Erny et al., 2015; Wekerle et al., 2016; Dinan et al., 2017; Johnson et al., 2018; Gareau et al., 2010).
Moreover, the emerging body of evidence indicates that both the onset and the progression of neurodevelopmental (Sherwin et al., 2016) and neurodegenerative disorders can be linked to gut dysbiosis (Quigley et al., 2017; Jiang et al., 2017; Barichella et al., 2018)
In light of the rapid expansion of the microbiome-brain interaction field, we propose this Special Issue to bring increased awareness to the diverse effect of the gut microbiome on brain homeostasis and disease. The objective of this Special Issue is to collate a series of reviews, commentaries, and research articles on the effect of the gut microbiome in various brain functions settings including, but not limited to, synaptic functions, neurodevelopmental and neurodegenerative diseases.
Dr. Silvia Di Angelantonio
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Synaptic functions;
- Glia-neuron interactions;
- Neurodegeneration;
- Neurodevelopment;
- Microbiota-gut-brain axis;
- Alzheimer’s Disease;
- Organoids
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
