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Cellular Reprogramming and Differentiation
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Cellular Reprogramming and Differentiation

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 6537

Special Issue Editors

Dr. Maryam Moshref

E-Mail Website
Guest Editor
1. Translational Medicine, Genentech (A Member of Roche Group), South San Francisco, CA 94015, USA
2. Alumni, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Interests: cell therapy; analytical development; stem cell biology; differentiation; reprogramming; regenerative medicine; T cell engineering; cardiac progenitor cells; stem cell hybrids; induced pluripotent stem cells (human, canine)
Dr. Charles A. Easley IV

E-Mail Website
Guest Editor
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, USA
Interests: regenerative medicine; stem cell therapies; male reproduction and fertility; spermatogenesis; fertility preservation; stem cell differentiation; environmental impacts on male fertility; induced pluripotent stem cells (human and non-human primate)
Dr. Krista Symosko

E-Mail Website
Guest Editor
Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA
Interests: male reproductive biology and toxicology; spermatogenesis; human induced pluripotent stem cells; regenerative medicine

Special Issue Information

Dear Colleagues,

We are pleased to invite you to The Journal of Developmental Biology (JDB) special issue addressing cellular reprogramming and differentiation. Over the last several decades, research has focused on the unique ability of stem cells to self-renew and differentiate towards a variety of cell types. With many basic science and preclinical studies demonstrating the potential capabilities of stem cell-based therapeutics in the clinic, this special edition is interested in bringing together the topics of cellular reprogramming and differentiation to lead to promising outcomes in advancing stem cell usage in basic science, translational medicine, and regenerative medicine.

This special issue welcomes original manuscripts and reviews from collective complementary expertise, spanning the following areas:

  • Novel approaches of microfluidic, organoid, and 3D cell culture applications;
  • Molecular and epigenetic mechanisms in stem cell (de)differentiation, transdifferentiation, and reprogramming;
  • Toxicology, drug discovery, and disease modeling;
  • Generation of clinical grade iPSC lines ;
  • Analytical development, characterization of the new cell lines and iPSC derived cell products;
  • Genetic manipulation in iPSC and iPSC products;
  • Stem cells and veterinary regenerative medicine.

We welcome your contributions and look forward to highlighting your work!

In addition, we would like to thank Mrs. Krista M. Symosko Crow’s support and contribution to this Special Issue.

Dr. Maryam Moshref
Dr. Charles A. Easley IV
Dr. Krista Symosko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Developmental Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular reprogramming
  • differentiation
  • stem cells
  • regenerative medicine
  • organoids

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Review

17 pages, 944 KiB  
Review
Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine
by Raiane Cristina Fratini de Castro, Tiago William Buranello, Kaiana Recchia, Aline Fernanda de Souza, Naira Caroline Godoy Pieri and Fabiana Fernandes Bressan
J. Dev. Biol. 2024, 12(2), 14; https://doi.org/10.3390/jdb12020014 - 7 May 2024
Cited by 1 | Viewed by 2198
Abstract
The generation of mature gametes and competent embryos in vitro from pluripotent stem cells has been successfully achieved in a few species, mainly in mice, with recent advances in humans and scarce preliminary reports in other domestic species. These biotechnologies are very attractive [...] Read more.
The generation of mature gametes and competent embryos in vitro from pluripotent stem cells has been successfully achieved in a few species, mainly in mice, with recent advances in humans and scarce preliminary reports in other domestic species. These biotechnologies are very attractive as they facilitate the understanding of developmental mechanisms and stages that are generally inaccessible during early embryogenesis, thus enabling advanced reproductive technologies and contributing to the generation of animals of high genetic merit in a short period. Studies on the production of in vitro embryos in pigs and cattle are currently used as study models for humans since they present more similar characteristics when compared to rodents in both the initial embryo development and adult life. This review discusses the most relevant biotechnologies used in veterinary medicine, focusing on the generation of germ-cell-like cells in vitro through the acquisition of totipotent status and the production of embryos in vitro from pluripotent stem cells, thus highlighting the main uses of pluripotent stem cells in livestock species and reproductive medicine. Full article
(This article belongs to the Special Issue Cellular Reprogramming and Differentiation)
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20 pages, 1536 KiB  
Review
Cell Reprogramming and Differentiation Utilizing Messenger RNA for Regenerative Medicine
by Masahito Inagaki
J. Dev. Biol. 2024, 12(1), 1; https://doi.org/10.3390/jdb12010001 - 20 Dec 2023
Cited by 1 | Viewed by 3508
Abstract
The COVID-19 pandemic generated interest in the medicinal applications of messenger RNA (mRNA). It is expected that mRNA will be applied, not only to vaccines, but also to regenerative medicine. The purity of mRNA is important for its medicinal applications. However, the current [...] Read more.
The COVID-19 pandemic generated interest in the medicinal applications of messenger RNA (mRNA). It is expected that mRNA will be applied, not only to vaccines, but also to regenerative medicine. The purity of mRNA is important for its medicinal applications. However, the current mRNA synthesis techniques exhibit problems, including the contamination of undesired 5′-uncapped mRNA and double-stranded RNA. Recently, our group developed a completely capped mRNA synthesis technology that contributes to the progress of mRNA research. The introduction of chemically modified nucleosides, such as N1-methylpseudouridine and 5-methylcytidine, has been reported by Karikó and Weissman, opening a path for the practical application of mRNA for vaccines and regenerative medicine. Yamanaka reported the production of induced pluripotent stem cells (iPSCs) by introducing four types of genes using a retrovirus vector. iPSCs are widely used for research on regenerative medicine and the preparation of disease models to screen new drug candidates. Among the Yamanaka factors, Klf4 and c-Myc are oncogenes, and there is a risk of tumor development if these are integrated into genomic DNA. Therefore, regenerative medicine using mRNA, which poses no risk of genome insertion, has attracted attention. In this review, the author summarizes techniques for synthesizing mRNA and its application in regenerative medicine. Full article
(This article belongs to the Special Issue Cellular Reprogramming and Differentiation)
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