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Biomaterials for Bioimaging and Detection
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Biomaterials for Bioimaging and Detection

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3891

Special Issue Editors

Prof. Dr. Changmin Yu

E-Mail Website
Guest Editor
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
Interests: optical materials in sensor; photoelectric device and chemical biology
Dr. Bo Peng

E-Mail Website
Guest Editor
Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi’an 710072, China
Interests: bioimaging; stimulus-responsive chemistry; organ-on-chips and drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Optical bioimaging based on functional biomaterials has been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages, such as high spatio-temporal resolution, favorable sensitivity, and biocompatibility. In addition, the large surface area and easy modifcation of nanomaterials provide a platform for the design of multifunctional nanoparticles for disease targeting, diagnosis, and treatment. Recently, functional bio-nanomaterials have been strategically integrated and designed with imaging contrast agents for various molecular imaging modalities including fluorescence imaging, magnetic resonance imaging, ultrasound imaging, or multimodal imaging. Specially, optical bioimaging in the near-infrared spectrum has shown great potential for guiding surgeons during complex interventions. We envision that different materials with distinct properties combined with bioimaging function could will get extensive applications in biological, medical, chemical and material fields as a new analytical method.

In this Special Issue, we invite researchers to provide original research articles, as well as review articles focusing on the topic “Biomaterials for Bioimaging and Detection”.

The Special Issue contents are expected to include but not be limited to:

  • Biomaterials for Bioimaging;
  • Biomaterials for disease diagnosis;
  • Biomaterials for monitoring disease biomarker;
  • Biomaterials for healthcare applications.
  • Optical biomaterials
  • Fluorescent nanosensors and contrast agents

Prof. Dr. Changmin Yu
Dr. Bo Peng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • bioimaging
  • fluorescence
  • detection
  • diagnosis
  • photoelectric device and biology

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Published Papers (2 papers)

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Research

12 pages, 2195 KiB  
Article
Development of a COX-2-Selective Fluorescent Probe for the Observation of Early Intervertebral Disc Degeneration
by Cheol Ho Heo, Eun Ji Roh, Jaehee Kim, Hyemin Choi, Ho Yeon Jang, Giseong Lee, Chang Su Lim and Inbo Han
J. Funct. Biomater. 2023, 14(4), 192; https://doi.org/10.3390/jfb14040192 - 29 Mar 2023
Cited by 4 | Viewed by 1974
Abstract
Cyclooxygenase-2 (COX-2) is a biomolecule known to be overexpressed in inflammation. Therefore, it has been considered a diagnostically useful marker in numerous studies. In this study, we attempted to assess the correlation between COX-2 expression and the severity of intervertebral disc (IVD) degeneration [...] Read more.
Cyclooxygenase-2 (COX-2) is a biomolecule known to be overexpressed in inflammation. Therefore, it has been considered a diagnostically useful marker in numerous studies. In this study, we attempted to assess the correlation between COX-2 expression and the severity of intervertebral disc (IVD) degeneration using a COX-2-targeting fluorescent molecular compound that had not been extensively studied. This compound, indomethacin-adopted benzothiazole-pyranocarbazole (IBPC1), was synthesized by introducing indomethacin—a compound with known selectivity for COX-2—into a phosphor with a benzothiazole-pyranocarbazole structure. IBPC1 exhibited relatively high fluorescence intensity in cells pretreated with lipopolysaccharide, which induces inflammation. Furthermore, we observed significantly higher fluorescence in tissues with artificially damaged discs (modeling IVD degeneration) compared to normal disc tissues. These findings indicate that IBPC1 can meaningfully contribute to the study of the mechanism of IVD degeneration in living cells and tissues and to the development of therapeutic agents. Full article
(This article belongs to the Special Issue Biomaterials for Bioimaging and Detection)
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9 pages, 1840 KiB  
Communication
Atomic Force Microscopy Study of the Effect of an Electric Field, Applied to a Pyramidal Structure, on Enzyme Biomolecules
by Yuri D. Ivanov, Vadim Y. Tatur, Ivan D. Shumov, Andrey F. Kozlov, Anastasia A. Valueva, Irina A. Ivanova, Maria O. Ershova, Nina D. Ivanova, Igor N. Stepanov, Andrei A. Lukyanitsa and Vadim S. Ziborov
J. Funct. Biomater. 2022, 13(4), 234; https://doi.org/10.3390/jfb13040234 - 10 Nov 2022
Viewed by 1539
Abstract
The influence of an external constant strong electric field, formed using a pyramidal structure under a high electric potential, on an enzyme located near its apex, is studied. Horseradish peroxidase (HRP) is used as a model. In our experiments, a 27 kV direct [...] Read more.
The influence of an external constant strong electric field, formed using a pyramidal structure under a high electric potential, on an enzyme located near its apex, is studied. Horseradish peroxidase (HRP) is used as a model. In our experiments, a 27 kV direct current (DC) voltage was applied to two electrodes with a conducting pyramidal structure attached to one of them. The enzyme particles were visualized by atomic force microscopy (AFM) after the adsorption of the enzyme from its 0.1 µM solution onto mica AFM substrates. It is demonstrated that after the 40 min exposure to the electric field, the enzyme forms extended structures on mica, while in control experiments compact HRP particles are observed. After the exposure to the electric field, the majority of mica-adsorbed HRP particles had a height of 1.2 nm (as opposed to 1.0 nm in the case of control experiments), and the contribution of higher (>2.0 nm) particles was also considerable. This indicates the formation of high-order HRP aggregates under the influence of an applied electric field. At that, the enzymatic activity of HRP against its substrate 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) remains unaffected. These results are important for studying macroscopic effects of strong electromagnetic fields on enzymes, as well as for the development of cellular structure models. Full article
(This article belongs to the Special Issue Biomaterials for Bioimaging and Detection)
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