Functional Biomaterial for Bone Regeneration

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1929

Special Issue Editors


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Guest Editor
Department of Integrative Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia
Interests: guided tissue regeneration; histology; immunohistochemistry; dental implantology; oral surgery

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Guest Editor
Department of Anatomy, Histology, Embryology, Pathological Anatomy and Pathological Histology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia
Interests: biomaterials; histology; bone tissue regeneration; regenerative medicine; macrophages; collagen; resorbable metal
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia
Interests: biomaterials; histology; bone tissue regeneration; immunohistochemistry; histomorphometry; periodontology

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Guest Editor
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea
Interests: bone regeneration; bioceramics; biopolymers; hydrogels; scaffolds; dentistry; angiogenesis; hemostasis; mechanosignalling; bone graft substitutes; bone fillers; bone cement; bioadhesives

Special Issue Information

Dear Colleagues,

It is generally recognized that the success of bone regeneration depends not only on the choice of a particular surgical technique and the clinical experience of the therapist, but also on the knowledge, correct selection, and use of various biomaterials. Therefore, the science of biomaterials is one of the fastest growing disciplines in dentistry, and a more thorough knowledge of the properties of existing biomaterials, as well as the development of new biomaterials, are certainly areas that require special research attention. We believe that the topic of this Special Issue is of great importance to professionals working in the field of tissue engineering, dental implantology, and regenerative dentistry, and that this issue provides a great opportunity to publish previously unaddressed topics related to biomaterials for bone regeneration.

Dr. Marija Čandrlić
Dr. Željka Perić Kačarević
Dr. Matej Tomas
Dr. Arun Kumar Rajendran
Guest Editors

Manuscript Submission Information

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Keywords

  • tissue regeneration
  • implant dentistry
  • bone substitutes
  • membranes
  • regenerative dental medicine

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Published Papers (1 paper)

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Research

16 pages, 13656 KiB  
Article
Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis
by Marija Čandrlić, Ana Terezija Jerbić Radetić, Hrvoje Omrčen, Barbara Franović, Lara Batičić, Tamara Gulić, Tea Čaljkušić-Mance, Sanja Zoričić Cvek, Lucija Malešić, Željka Perić Kačarević and Olga Cvijanović Peloza
J. Funct. Biomater. 2024, 15(9), 270; https://doi.org/10.3390/jfb15090270 - 18 Sep 2024
Viewed by 1215
Abstract
The aim of this study was to evaluate the efficacy of autologous dentin (AD), bovine xenograft (BX) and magnesium-enriched bovine xenograft (BX + Mg) in the healing of critical cranial bone defects (CCBDs) in rats. Eighty male Wistar rats were divided into four [...] Read more.
The aim of this study was to evaluate the efficacy of autologous dentin (AD), bovine xenograft (BX) and magnesium-enriched bovine xenograft (BX + Mg) in the healing of critical cranial bone defects (CCBDs) in rats. Eighty male Wistar rats were divided into four groups: BX, BX + Mg, AD and the control group (no intervention). Eight mm CCBDs were created and treated with the respective biomaterials. Healing was assessed 7, 15, 21 and 30 days after surgery by micro-computed tomography (micro-CT), real-time polymerase chain reaction (RT-PCR) and immunohistochemical analysis. Micro-CT analysis showed that AD had the highest bone volume and the least amount of residual biomaterial at day 30, indicating robust bone formation and efficient resorption. BX + Mg showed significant bone volume but had more residual biomaterial compared to AD. RT-PCR showed that the expression of osteocalcin (OC), the receptor activator of nuclear factor κB (RANK) and sclerostin (SOST), was highest in the AD group at day 21 and vascular endothelial growth factor (VEGF) at day 15, indicating increased osteogenesis and angiogenesis in the AD group. Immunohistochemical staining confirmed intense BMP-2/4 and SMAD-1/5/8 expression in the AD group, indicating osteoinductive properties. The favorable gene expression profile and biocompatibility of AD and BX + Mg make them promising candidates for clinical applications in bone tissue engineering. Further research is required to fully exploit their potential in regenerative surgery. Full article
(This article belongs to the Special Issue Functional Biomaterial for Bone Regeneration)
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