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Synthesis, Biomanufacturing, and Bio-Application of Advanced Polymers
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Synthesis, Biomanufacturing, and Bio-Application of Advanced Polymers

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 2993

Special Issue Editors

Dr. Yujia Zhang

E-Mail Website
Guest Editor
Chemistry Research Laboratory, Department of Chemistry, 12 Mansfield Road, Oxford OX1 3TA, UK
Interests: biomedical engineering; soft implants; intelligent iontronics; biomaterials; energy devices; synthetic tissues; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Tiemei Lu

E-Mail Website
Guest Editor
Department of Chemistry, University of Oxford, Oxford, UK
Interests: coacervates; condensates; liposomes; synthetic tissues; bio-inspired materials; polyelectrolytes; polymer composites
Dr. Cheryl Tan

E-Mail Website
Guest Editor
Ludwig Cancar Research, Nuffield department of Medicine, University of Oxford, Oxford, UK
Interests: induced pluripotent potent stem cells; cell biology; molecular biology; vascular biology; bioprinting

Special Issue Information

Dear Colleagues,

Advanced polymers for biological applications represent foundational scaffold components in tissue engineering, regenerative medicine, and other medical fields. Tailoring the advanced properties offered by the polymer’s compositions, structures, and functionalities through biomanufacturing techniques to interface living matter has sparked remarkable interdisciplinary research interest. These techniques include, but are not limited to, 3D printing, electrospinning, microfluidics, injectables, patterning, and casting. Biomanufacturing techniques combine biomechanical modelling, engineering reformation, material functionalisation, and cell biology development to construct innovative results that could benefit clinical applications in the future.

Given the thriving nature of biopolymers in bioengineering applications, this Special Issue aims to showcase the state-of-the-art advances in polymer-related medical applications such as synthetic cell and tissue, coacervate, drug delivery, biomedical sensing and treatment, bio-inspired devices, biological interfaces, organoids, induced pluripotent stem cells, etc. We look forward to your submission of intriguing results that will enrich and inspire this interdisciplinary field.

Dr. Yujia Zhang
Dr. Tiemei Lu
Dr. Cheryl Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer
  • tissue engineering
  • biofabrication
  • medical device
  • bio-inspired device
  • biological interface
  • synthetic cell and tissue

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Published Papers (2 papers)

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Research

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15 pages, 5033 KiB  
Article
Electrospun Silk-ICG Composite Fibers and the Application toward Hemorrhage Control
by Ayesha Siddiqua, Elwin Clutter, Olga Garklavs, Hemalatha Kanniyappan and Rong R. Wang
J. Funct. Biomater. 2024, 15(9), 272; https://doi.org/10.3390/jfb15090272 - 19 Sep 2024
Viewed by 1188
Abstract
In trauma and surgery, efficient hemorrhage control is crucial to avert fatal blood loss and increase the likelihood of survival. There is a significant demand for novel biomaterials capable of promptly and effectively managing bleeding. This study aimed to develop flexible biocomposite fibrous [...] Read more.
In trauma and surgery, efficient hemorrhage control is crucial to avert fatal blood loss and increase the likelihood of survival. There is a significant demand for novel biomaterials capable of promptly and effectively managing bleeding. This study aimed to develop flexible biocomposite fibrous scaffolds with an electrospinning technique using silk fibroin (SF) and indocyanine green (ICG). The FDA-approved ICG dye has unique photothermal properties. The water permeability, degradability, and biocompatibility of Bombyx mori cocoon-derived SF make it promising for biomedical applications. While as-spun SF-ICG fibers were dissolvable in water, ethanol vapor treatment (EVT) effectively induced secondary structural changes to promote β-sheet formation. This resulted in significantly improved aqueous stability and mechanical strength of the fibers, thereby increasing their fluid uptake capability. The enhanced SF-ICG interaction effectively prevented ICG leaching from the composite fibers, enabling them to generate heat under NIR irradiation due to ICG’s photothermal properties. Our results showed that an SF-ICG 0.4% fibrous matrix can uptake 473% water. When water was replaced by bovine blood, a 25 s NIR irradiation induced complete blood coagulation. However, pure silk did not have the same effect. Additionally, NIR irradiation of the SF-ICG fibers successfully stopped the flow of blood in an in vitro model that mimicked a damaged blood vessel. This novel breakthrough offers a biotextile platform poised to enhance patient outcomes across various medical scenarios, representing a significant milestone in functional biomaterials. Full article
(This article belongs to the Special Issue Synthesis, Biomanufacturing, and Bio-Application of Advanced Polymers)
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Review

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14 pages, 8200 KiB  
Review
Recent Progress in Artificial Neurons for Neuromodulation
by Qinkai Jiang and Mengwei Liu
J. Funct. Biomater. 2024, 15(8), 214; https://doi.org/10.3390/jfb15080214 - 30 Jul 2024
Viewed by 1448
Abstract
Driven by the rapid advancement and practical implementation of biomaterials, fabrication technologies, and artificial intelligence, artificial neuron devices and systems have emerged as a promising technology for interpreting and transmitting neurological signals. These systems are equipped with multi-modal bio-integrable sensing capabilities, and can [...] Read more.
Driven by the rapid advancement and practical implementation of biomaterials, fabrication technologies, and artificial intelligence, artificial neuron devices and systems have emerged as a promising technology for interpreting and transmitting neurological signals. These systems are equipped with multi-modal bio-integrable sensing capabilities, and can facilitate the benefits of neurological monitoring and modulation through accurate physiological recognition. In this article, we provide an overview of recent progress in artificial neuron technology, with a particular focus on the high-tech applications made possible by innovations in material engineering, new designs and technologies, and potential application areas. As a rapidly expanding field, these advancements have a promising potential to revolutionize personalized healthcare, human enhancement, and a wide range of other applications, making artificial neuron devices the future of brain-machine interfaces. Full article
(This article belongs to the Special Issue Synthesis, Biomanufacturing, and Bio-Application of Advanced Polymers)
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