Feature Papers in Biomaterials for Cancer Therapies

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Cancer Therapies".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 6507

Special Issue Editor

Special Issue Information

Dear Colleagues,

Despite the advancement in current treatments for many malignant neoplasms, the prognosis for several cancers is still largely unfavorable. A main reason is that tumor biology and the tumor microenvironment are not fully mastered; thus, therapies cannot be pinpoint and effective. Not only new drugs have to be developed and tested, but also precise and personalized administration routes have to be assessed, along with understanding and correcting the genetic and epigenetic multifactorial aspects of cancer.

This Special Issue aims to collect and highlight the special and multifold role of biomaterials in ameliorating cancer therapies, thus unveiling novel opportunities to treat and study this disease. Biomaterials offer an infinitely versatile platform of smart tools to be applied in such a complex pathologic scenario, including, but not limited to, biomaterial-based approaches (i.e., nano/micro particles and robots) for systemic or targeted delivery of single or combined chemo/bioactive factors, for imaging enhancement, and thermal ablation, as well as biomaterial-based percutaneous or implantable devices for the local administration of chemotherapy, for metastasis trap, or the induction of cancer-immunotherapy. In addition, the promising application of biomaterials to study cancers encompasses hydrogels and polymeric scaffolds to tissue engineer complex 3D in vitro models representative of the tumor microenvironment, and also supports cancer-on-chip technology to investigate drug performance in a personalized fashion. Owing to their versatile and easily tunable properties, biomaterials hold promise for the treatment and study of neoplasms, thereby largely contributing to the societal challenge of cancer. Review papers, original contributions and perspective articles facing any aspect of biomaterials (biologic synthetic, bioartificial or composite), also a part of a device, on this topic are greatly welcome for this Special Issue.

Dr. Serena Danti
Guest Editor

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Keywords

  • biomaterials applications to fight cancers

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Published Papers (1 paper)

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Review

27 pages, 5562 KiB  
Review
Hydroxyapatite Nanoparticles for Improved Cancer Theranostics
by Saeid Kargozar, Sahar Mollazadeh, Farzad Kermani, Thomas J. Webster, Simin Nazarnezhad, Sepideh Hamzehlou and Francesco Baino
J. Funct. Biomater. 2022, 13(3), 100; https://doi.org/10.3390/jfb13030100 - 20 Jul 2022
Cited by 39 | Viewed by 5772
Abstract
Beyond their well-known applications in bone tissue engineering, hydroxyapatite nanoparticles (HAp NPs) have also been showing great promise for improved cancer therapy. The chemical structure of HAp NPs offers excellent possibilities for loading and delivering a broad range of anticancer drugs in a [...] Read more.
Beyond their well-known applications in bone tissue engineering, hydroxyapatite nanoparticles (HAp NPs) have also been showing great promise for improved cancer therapy. The chemical structure of HAp NPs offers excellent possibilities for loading and delivering a broad range of anticancer drugs in a sustained, prolonged, and targeted manner and thus eliciting lower complications than conventional chemotherapeutic strategies. The incorporation of specific therapeutic elements into the basic composition of HAp NPs is another approach, alone or synergistically with drug release, to provide advanced anticancer effects such as the capability to inhibit the growth and metastasis of cancer cells through activating specific cell signaling pathways. HAp NPs can be easily converted to smart anticancer agents by applying different surface modification treatments to facilitate the targeting and killing of cancer cells without significant adverse effects on normal healthy cells. The applications in cancer diagnosis for magnetic and nuclear in vivo imaging are also promising as the detection of solid tumor cells is now achievable by utilizing superparamagnetic HAp NPs. The ongoing research emphasizes the use of HAp NPs in fabricating three-dimensional scaffolds for the treatment of cancerous tissues or organs, promoting the regeneration of healthy tissue after cancer detection and removal. This review provides a summary of HAp NP applications in cancer theranostics, highlighting the current limitations and the challenges ahead for this field to open new avenues for research. Full article
(This article belongs to the Special Issue Feature Papers in Biomaterials for Cancer Therapies)
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