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Advanced Materials for Clinical Endodontic Applications (2nd Edition)
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Advanced Materials for Clinical Endodontic Applications (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 3932

Special Issue Editors

Prof. Dr. Saulius Drukteinis

E-Mail Website
Guest Editor
Institute of Odontology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania
Interests: engine-driven root canal instruments; root canal filling materials; hydraulic calcium silicate cement
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sivaprakash Rajasekharan

E-Mail Website1 Website2
Guest Editor
Department of Paediatric Dentistry, School of Oral Health Sciences, Ghent University, B-9000 Ghent, Belgium
Interests: dental; silicate cement; Medline; endodontics dentistry; pediatric dentistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Matthias Widbiller

E-Mail Website
Guest Editor
Department of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, D-93093 Regensburg, Germany
Interests: pulp biology; tissue engineering; dentin matrix proteins; dental pulp stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

It is a great pleasure to welcome you to contribute to this Special Issue titled “Advanced Materials for Clinical Endodontic Applications II”. During the last few decades, many new instruments and materials have been developed and introduced to the market. Along with these innovations, the new, more clinically appealing, and promising techniques of root canal cleaning, shaping, and obturation were introduced to increase the success rates of endodontic treatment, retreatment, and survival of endodontically treated teeth.

This Special Issue of the Journal of Functional Biomaterials will cover different topics of new biomaterials developed for endodontic application: materials for disinfection/irrigation of the root canal system, temporary and permanent endoaccess and root canal filling, management of endodontic complications, regenerative endodontics, or endodontic surgery.

This Special Issue will accept and publish high-quality original articles, short communications, and review articles in the field of modern endodontic materials. In addition, papers presenting results of in vitro, in vivo, or clinical studies are all welcomed.

Prof. Dr. Saulius Drukteinis
Prof. Dr. Sivaprakash Rajasekharan
Prof. Dr. Matthias Widbiller
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sealers
  • bioceramic
  • biomaterials
  • nanomaterials
  • irrigants
  • endodontic materials
  • regenerative endodontics
  • endodontic complications
  • endodontic surgery
  • root canal filling
  • tricalcium silicates
  • bioactive materials
  • pediatric endodontic materials

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Published Papers (4 papers)

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Research

13 pages, 4105 KiB  
Article
In Vitro Microscopical and Microbiological Assessment of the Sealing Ability of Calcium Silicate-Based Root Canal Sealers
by Karin Christine Huth, Sabina Noreen Wuersching, Leander Benz, Stefan Kist and Maximilian Kollmuss
J. Funct. Biomater. 2024, 15(11), 341; https://doi.org/10.3390/jfb15110341 - 12 Nov 2024
Viewed by 496
Abstract
This in vitro study evaluated the sealing ability and microleakage of calcium silicate-based sealers compared to an epoxy resin-based sealer. One hundred twenty-five roots from anterior teeth were chemo-mechanically prepared and divided into four groups: AH Plus (AH), ProRoot MTA (PR), Medcem MTA [...] Read more.
This in vitro study evaluated the sealing ability and microleakage of calcium silicate-based sealers compared to an epoxy resin-based sealer. One hundred twenty-five roots from anterior teeth were chemo-mechanically prepared and divided into four groups: AH Plus (AH), ProRoot MTA (PR), Medcem MTA (MC), and Total Fill BC Sealer/BC-coated gutta-percha (TF); n = 30. Confocal laser scanning microscopy was used to measure sealer penetration at three horizontal levels in 10 roots per group, while glucose leakage over 30 days was assessed in 20 roots. A lateral compaction technique was used for most groups, except for TF, which employed a single-cone method. Data were analyzed using Python with a Kruskal–Wallis test and Dunn’s post hoc test. TF showed significantly greater penetration in the coronal and middle sections, while PR had the least penetration in the apical section. PR exhibited the highest canal circumference penetration, especially compared to MC and TF. Glucose leakage increased over time in all groups, with TF showing the highest permeability after 30 days. Overall, calcium silicate-based sealers PR, MC, and TF performed similarly to the epoxy resin standard AH, with all groups exhibiting decreasing penetration from coronal to apical and increased leakage over time. Full article
(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (2nd Edition))
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11 pages, 1565 KiB  
Article
An Evaluation of the Cytocompatibility of Endodontic Bioceramics in Human Periodontal-Ligament-Derived Cells
by Asuka Aka, Takashi Matsuura and Atsutoshi Yoshimura
J. Funct. Biomater. 2024, 15(8), 231; https://doi.org/10.3390/jfb15080231 - 19 Aug 2024
Viewed by 737
Abstract
The present study evaluated the cytocompatibility of three endodontic bioceramics in human periodontal-ligament-derived cells (hPDLCs): MTA Repair HP (HP), MTA Flow White (F), and Nishika Canal Sealer BG multi (BG). In addition, we also evaluated the effect of the powder–liquid (paste) ratio of [...] Read more.
The present study evaluated the cytocompatibility of three endodontic bioceramics in human periodontal-ligament-derived cells (hPDLCs): MTA Repair HP (HP), MTA Flow White (F), and Nishika Canal Sealer BG multi (BG). In addition, we also evaluated the effect of the powder–liquid (paste) ratio of F and BG on cytocompatibility. Discs of endodontic bioceramics (diameter = 8 mm, thickness = 1 mm) were prepared with HP, F, and BG. hPDLCs obtained from extracted teeth and cultured for three to five passages were used in the experiment. The prepared discs were placed at the bottom of a 48-well plate, seeded with hPDLCs at 100,000 cells/well, cultured for 7 or 28 days, and subjected to a 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. hPDLCs cultured without any discs were used as a negative control (NC) group. Discs made of F or BG mixed in three different consistencies were also used in this experiment. The absorbance values at days 7 and 28 were high in the order of HP > NC > BG > F. Furthermore, F or BG with higher consistency showed higher absorbance values. MTA Repair HP had the highest cytocompatibility among the three materials. Furthermore, it also showed that higher consistency improved cytocompatibility. Full article
(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (2nd Edition))
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15 pages, 6283 KiB  
Article
Chitosan–Gelatin Scaffolds Loaded with Different Antibiotic Formulations for Regenerative Endodontic Procedures Promote Biocompatibility and Antibacterial Activity
by Maha Alghofaily, Aljowhara Almana, Jenan Alrayes, Rhodanne Lambarte, Michael D. Weir and Fahd Alsalleeh
J. Funct. Biomater. 2024, 15(7), 186; https://doi.org/10.3390/jfb15070186 - 4 Jul 2024
Cited by 1 | Viewed by 1185
Abstract
Background: This study investigated the biocompatibility and antibacterial efficacy of chitosan–gelatin (CH-G) scaffolds loaded with slow-releasing antibiotic formulations used in regeneration endodontic procedures (REPs). Methods: Scaffolds were fabricated using freeze drying and loaded with varying concentrations of augmentin or modified triple antibiotic paste [...] Read more.
Background: This study investigated the biocompatibility and antibacterial efficacy of chitosan–gelatin (CH-G) scaffolds loaded with slow-releasing antibiotic formulations used in regeneration endodontic procedures (REPs). Methods: Scaffolds were fabricated using freeze drying and loaded with varying concentrations of augmentin or modified triple antibiotic paste (mTAP). High-resolution scanning electron microscopy (SEM) was used to characterize the scaffold, while drug release was monitored via UV-Vis spectrophotometry. Immortalized human mesenchymal stem cells (hMSCs) were cultured on CH-G scaffolds alone (control), either 0.1 mg/mL or 1 mg/mL of augmentin or mTAP, and 10 mg/mL calcium hydroxide (Ca(OH)2). Cell viability and proliferation were assessed using the Alamar Blue assay and SEM, respectively, and live/dead staining further corroborated cell viability. Antibacterial activity against Enterococcus faecalis was evaluated using the MTT assay and confocal laser scanning microscopy (CLSM). Results: Augmentin at 0.1 mg/mL appeared to promote better cell growth and attachment within the scaffolds than all other formulations, exhibiting acceptable viability. SEM revealed improved cell attachment in augmentin and mTAP groups compared to the Ca(OH)2 group. Augmentin at 1 mg/mL and mTAP groups significantly reduced viable bacteria compared to controls. Augmentin groups and mTAP at 1 mg/mL were highly effective in eliminating E. faecalis biofilms, with mTAP potentially causing more cell death within the remaining biofilm structures. Conclusions: This study suggests that CH-G scaffolds loaded with augmentin and mTAP, particularly at a concentration of 1 mg/mL, offer promising advantages for REPs due to their biocompatibility, antibacterial efficacy, and ability to promote cell attachment. Further research may explore the long-term effects in clinical settings. Full article
(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (2nd Edition))
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10 pages, 1212 KiB  
Article
Effect of Calcium Silicate-Based Intracanal Medicament and Calcium Hydroxide on Growth Factor TGF-β1 Release from Root Canal Dentine
by Goda Bilvinaite, Saulius Drukteinis, Egidijus Simoliunas, Matthias Widbiller and Simas Sakirzanovas
J. Funct. Biomater. 2024, 15(6), 139; https://doi.org/10.3390/jfb15060139 - 22 May 2024
Cited by 1 | Viewed by 1036
Abstract
Effective root canal disinfection and the subsequent release of natural growth factors from dentin are crucial to the success of regenerative endodontic procedures. This study evaluated the effect of newly introduced calcium silicate-based temporary intracanal medicament Bio-C Temp and calcium hydroxide-based material UltraCal [...] Read more.
Effective root canal disinfection and the subsequent release of natural growth factors from dentin are crucial to the success of regenerative endodontic procedures. This study evaluated the effect of newly introduced calcium silicate-based temporary intracanal medicament Bio-C Temp and calcium hydroxide-based material UltraCal XS on the release of transforming growth factor β1 (TGF-β1) from root canal dentin. Twenty-two intact and fully developed human premolars from patients aged 15–18 were shaped and irrigated according to the current clinical recommendations. The teeth were then gently split in half, and the root canal dentin of paired samples was covered with Bio-C Temp or UltraCal XS. After 3 weeks of incubation, the specimens were conditioned with 17% EDTA and the collected solution was subjected to the quantification of the released TGF-β1 by performing an ELISA. One-way analysis of variance (ANOVA), followed by Tukey’s test, was selected to determine the statistically significant differences between the groups at the 0.95 confidence level. The highest mean value of released TGF-β1 (1993.1 pg/mL) was detected in the control group, where the root canal dentin was conditioned with 17% EDTA alone. Regarding the experimental groups, Bio-C Temp released a statistically significantly higher amount of TGF-β1 (282.14 pg/mL) compared to UltraCal XS (114.28 pg/mL; p = 0.0158). Bio-C Temp affected the release of growth factors from root canal dentin less than UltraCal XS and may therefore serve as an intracanal medicament for regenerative endodontic procedures. Full article
(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (2nd Edition))
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