Novel Biomaterials for Tissue Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1405

Special Issue Editors


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Guest Editor
Bristol Medical School (THS), University of Bristol, Bristol, UK
Interests: bioprinting; tissue engineering; bioinspired materials; protein-based materials
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Bristol Medical School (THS), University of Bristol, Bristol, UK
Interests: biomaterials; hydrogels; tissue engineering; chemical and physical modifications; drug delivery systems

Special Issue Information

Dear Colleagues,

Tissue engineering is the development of biomaterials that guide tissue regeneration while providing mechanical support and biological cues. Understanding the biological principles of tissue growth and the interplay between cells and biomaterials is crucial. Advancements in manufacturing technologies enable the precise control of biomaterial properties, allowing tailored approaches to address specific clinical needs.

Advanced biomaterials are essential for tissue engineering, aiding in regenerating and repairing damaged tissues or organs. The integration of advanced biomaterials with diagnostic technologies is also crucial for real-time monitoring and feedback. For instance, incorporating sensors and imaging modalities into biomaterials will enable researchers to create materials that respond actively to environmental changes, enhancing therapeutic efficacy.

This Special Issue explores the latest advancements in biomaterials and fabrication technologies tailored for regenerative medicine. Topics of interest include, but are not limited to, the following:

  1. Novel fabrication technologies;
  2. Cutting-edge features and design requirements of biofabricated structures;
  3. The development of innovative biomaterials;
  4. Stimuli-responsive materials for drug delivery systems;
  5. Self-assembling and self-healing materials for biomedical applications.

We encourage the submission of original research, review articles, short communications, and perspectives that elucidate the current state of the art of advanced biomaterials in regenerative medicine and provide insights into the future directions of this field.

Dr. Farnaz Ghorbani
Dr. Mina Aleemardani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biomacromolecules
  • tissue engineering
  • scaffolds
  • biofabrication
  • regenerative medicine
  • drug delivery

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Published Papers (1 paper)

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Research

18 pages, 2903 KiB  
Article
Evaluating the Effects of BSA-Coated Gold Nanorods on Cell Migration Potential and Inflammatory Mediators in Human Dermal Fibroblasts
by Nouf N. Mahmoud, Ayat S. Hammad, Alaya S. Al Kaabi, Hend H. Alawi, Summaiya Khatoon and Maha Al-Asmakh
J. Funct. Biomater. 2024, 15(10), 284; https://doi.org/10.3390/jfb15100284 - 26 Sep 2024
Viewed by 1034
Abstract
Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with limited exploration. In this study, gold nanorods (GNR) were prepared and coated with bovine serum albumin (BSA) [...] Read more.
Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with limited exploration. In this study, gold nanorods (GNR) were prepared and coated with bovine serum albumin (BSA) to produce GNR-BSA. The functionalized nanoparticles were characterized based on their optical absorption spectra, morphology, surface charge, and quantity of attached protein. The interaction between GNR-BSA and BSA with normal cells was investigated using human dermal fibroblasts. The cytotoxicity test indicated cell viability between ~63–95% for GNR-BSA over concentrations from 30.0 to 0.47 μg/mL and ~85–98% for BSA over concentrations from 4.0 to 0.0625 mg/mL. The impact of the GNR-BSA and BSA on cell migration potential and wound healing was assessed using scratch assay, and the modulation of cytokine release was explored by quantifying a panel of cytokines using Multiplex technology. The results indicated that GNR-BSA, at 10 μg/mL, delayed the cell migration and wound healing 24 h post-treatment compared to the BSA or the control group with an average wound closure percentage of 6% and 16% at 6 and 24 h post-treatment, respectively. Multiplex analysis revealed that while GNR-BSA reduced the release of the pro-inflammatory marker IL-12 from the activated fibroblasts 24 h post-treatment, they significantly reduced the release of IL-8 (p < 0.001), and CCL2 (p < 0.01), which are crucial for the inflammation response, cell adhesion, proliferation, migration, and angiogenesis. Although GNR-BSA exhibited relatively high cell viability towards human dermal fibroblasts and promising therapeutic applications, toxicity aspects related to cell motility and migration must be considered. Full article
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering)
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