Progress and Challenges in Antimicrobial Resistance

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 894

Special Issue Editors


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Guest Editor
Cooperativa de Ensino Superior, Politécnico e Universitário, Gandra, Portugal
Interests: microbiology; microbial forensics; botany; botany forensic; molecular markers; genetics
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Guest Editor
LAQV-REQUIMTE, Research Centre in Health and Environment (CISA), Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal
Interests: pharmaceutical sciences; adverse drug reactions (ADR); antibiotics; microbiology; genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the rising threat of antimicrobial resistance (AMR) has emerged as a pressing global challenge to human health, animal welfare, and environmental sustainability. The widespread nature of AMR demands a multidisciplinary approach to understand its mechanisms, implications, and potential mitigation strategies. Over the past decade, remarkable advancements in microbiology have provided unique insights into the complex dynamics of AMR. For instance, several recently published manuscripts have enlightened the power of metagenomics in deciphering the global landscape of antimicrobial resistance. These studies shed light on the diverse reservoirs of resistance genes across urban microbiomes worldwide, characterize the genetic determinants of resistance, explore the role of microbial communities in propagating resistance traits, and elucidate the ecological factors shaping the dissemination of resistance genes.

This Special Issue of the Journal of Fungi and Microorganisms aims to explore the recent advances in antimicrobial resistance, considering the developments observed in the last ten years. As such, this Special Issue seeks to further clarify the intricate interplay between microbial communities, antimicrobial agents, and resistance mechanisms. Furthermore, it intends to explore the clinical, veterinary, agricultural, and environmental dimensions of this problem, encompassing studies on novel therapeutic approaches, surveillance strategies, and interventions to mitigate the spread of resistance.

We invite contributions that encompass original research articles, reviews, perspectives, and commentaries addressing various aspects of AMR. Through collaborative efforts and interdisciplinary dialogue, we aim to advance our collective knowledge and contribute to the global efforts to combat antimicrobial resistance.

Sincerely,
Dr. Manuela Oliveira
Dr. Diana Dias Da Silva
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance
  • novel therapeutics
  • resistance mechanisms
  • molecular epidemiology
  • one health approach

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Published Papers (1 paper)

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Research

10 pages, 1469 KiB  
Article
The Effects of COVID-19 on Antifungal Prescribing in the UK—Lessons to Learn
by Katharine Pates, Zhendan Shang, Rebeka Jabbar, Darius Armstrong-James, Silke Schelenz, Jimstan Periselneris, Rossella Arcucci and Anand Shah
J. Fungi 2024, 10(11), 787; https://doi.org/10.3390/jof10110787 - 13 Nov 2024
Viewed by 427
Abstract
Fungal infections are increasingly prevalent; however, antifungal stewardship attracts little funding or attention. Previous studies have shown that knowledge of guidelines and scientific evidence regarding antifungals is poor, leading to prescribing based on personal experiences and the inherent biases this entails. We carried [...] Read more.
Fungal infections are increasingly prevalent; however, antifungal stewardship attracts little funding or attention. Previous studies have shown that knowledge of guidelines and scientific evidence regarding antifungals is poor, leading to prescribing based on personal experiences and the inherent biases this entails. We carried out a retrospective study of inpatient antifungal usage at two major hospitals. We assessed the longitudinal trends in antifungal usage and the effect of COVID-19 on antifungal prescription, alongside levels of empirical and diagnostically targeted antifungal usage. Our results showed that the longitudinal patterns of total systemic antifungal usage within the trusts were similar to national prescribing trends; however, the composition of antifungals varied considerably, even when looking exclusively at the more homogenous group of COVID-19 patients. We showed a high level of empirical antifungal use in COVID-19 patients, with neither trust adhering to international recommendations and instead appearing to follow prior prescribing habits. This study highlights the significant challenges to optimise antifungal use with prescribing behaviour largely dictated by habit, a lack of adherence to guidelines, and high rates of empirical non-diagnostic-based prescribing. Further research and resources are required to understand the impact of antifungal stewardship on improving antifungal prescribing behaviours in this setting and the effects on outcome. Full article
(This article belongs to the Special Issue Progress and Challenges in Antimicrobial Resistance)
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