Progress and Challenges in Antimicrobial Resistance

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 6205

Special Issue Editors


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Guest Editor
1. Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences, CESPU, Avenida Central de Gandra 1317, 4585-116 Gandra, Portugal
2. UCIBIO, Research Unit on Applied Molecular Biosciences, Forensic Sciences Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), Avenida Central de Gandra 1317, 4585-116 Gandra, Portugal
Interests: microbiology; microbial forensics; botany; botany forensic; molecular markers; genetics
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LAQV-REQUIMTE, Research Centre in Health and Environment (CISA), Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal
Interests: pharmaceutical sciences; adverse drug reactions (ADR); antibiotics; microbiology; genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the rising threat of antimicrobial resistance (AMR) has emerged as a pressing global challenge to human health, animal welfare, and environmental sustainability. The widespread nature of AMR demands a multidisciplinary approach to understand its mechanisms, implications, and potential mitigation strategies. Over the past decade, remarkable advancements in microbiology have provided unique insights into the complex dynamics of AMR. For instance, several recently published manuscripts have enlightened the power of metagenomics in deciphering the global landscape of antimicrobial resistance. These studies shed light on the diverse reservoirs of resistance genes across urban microbiomes worldwide, characterize the genetic determinants of resistance, explore the role of microbial communities in propagating resistance traits, and elucidate the ecological factors shaping the dissemination of resistance genes.

This Special Issue of the Journal of Fungi and Microorganisms aims to explore the recent advances in antimicrobial resistance, considering the developments observed in the last ten years. As such, this Special Issue seeks to further clarify the intricate interplay between microbial communities, antimicrobial agents, and resistance mechanisms. Furthermore, it intends to explore the clinical, veterinary, agricultural, and environmental dimensions of this problem, encompassing studies on novel therapeutic approaches, surveillance strategies, and interventions to mitigate the spread of resistance.

We invite contributions that encompass original research articles, reviews, perspectives, and commentaries addressing various aspects of AMR. Through collaborative efforts and interdisciplinary dialogue, we aim to advance our collective knowledge and contribute to the global efforts to combat antimicrobial resistance.

You may choose our Joint Special Issue in Journal of Fungi.

Sincerely,
Dr. Manuela Oliveira
Dr. Diana Dias Da Silva
Guest Editors

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Keywords

  • antibiotic resistance
  • novel therapeutics
  • resistance mechanisms
  • molecular epidemiology
  • one health approach

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Published Papers (1 paper)

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Review

51 pages, 2630 KiB  
Review
An Overview of the Recent Advances in Antimicrobial Resistance
by Manuela Oliveira, Wilson Antunes, Salete Mota, Áurea Madureira-Carvalho, Ricardo Jorge Dinis-Oliveira and Diana Dias da Silva
Microorganisms 2024, 12(9), 1920; https://doi.org/10.3390/microorganisms12091920 - 21 Sep 2024
Viewed by 5469
Abstract
Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires a comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by its widespread prevalence and constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every [...] Read more.
Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires a comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by its widespread prevalence and constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, and selective pressure) contribute to the emergence and dissemination of new resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention and control strategies—IPCs) emphasize the importance of responsible antimicrobial use and surveillance. A One Health approach (i.e., the interconnectedness of human, animal, and environmental health) highlights the necessity for interdisciplinary collaboration and holistic strategies in combating AMR. Advancements in novel therapeutics (e.g., alternative antimicrobial agents and vaccines) offer promising avenues in addressing AMR challenges. Policy interventions at the international and national levels also promote ASPs aiming to regulate antimicrobial use. Despite all of the observed progress, AMR remains a pressing concern, demanding sustained efforts to address emerging threats and promote antimicrobial sustainability. Future research must prioritize innovative approaches and address the complex socioecological dynamics underlying AMR. This manuscript is a comprehensive resource for researchers, policymakers, and healthcare professionals seeking to navigate the complex AMR landscape and develop effective strategies for its mitigation. Full article
(This article belongs to the Special Issue Progress and Challenges in Antimicrobial Resistance)
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