Pathogenic Fungi: Morphogenesis, Pathogenicity and Biosynthesis of Secondary Metabolites—Second Edition

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 524

Special Issue Editor


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Guest Editor
Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province, Key Laboratory of Biopesticide and Chemical Biology of Education Ministry, Proteomic Research Center, and School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Interests: the regulatory mechanism of morphogenesis; secondary metabolism and pathogenicity, especially in the field of epigenetics
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Special Issue Information

Dear Colleagues,

There are an estimated 1.5 million species of fungi, among which pathogenic fungi can cause diseases to humans, plants, animals and even other fungi. Morphological changes are required for pathogenic fungi to cause disease. Physiological and environmental stimuli regulate morphogenic differentiation through conserved signaling pathways. In addition to cell size and shape, morphogenesis is linked to changes in cell surface composition, which are required by diverse microbes to be successful as pathogens. Pathogenic fungi utilize various pathogenic effectors to infect their hosts. The effectors are important virulence determinants of pathogenic fungi and play important roles in successful pathogenesis, predominantly by avoiding the host surveillance system. However, besides being important for pathogenesis, fungal effectors might be recognized by resistant cultivars of the host which produce a strong immune response to ward off pathogens. Pathogenic fungi, such as Aspergillus, Penicillium, Fusarium and Alternaria toxigenic species, are found to produce a wide variety of toxic secondary metabolites which seriously threaten human health and green agricultural practice.

In recent years, the development of molecular biology tools has led to the development of faster, more reliable detection techniques, providing valuable insights into the mechanisms underlying the adaptation and speciation of pathogenic fungi. The aim of this Special Issue is to characterize the morphogenesis, pathogenicity and biosynthesis of secondary metabolites of pathogenic fungi through comprehensive reviews, original studies and novel perspectives.

Prof. Dr. Zhenhong Zhuang
Guest Editor

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Keywords

  • pathogenic fungi
  • morphogenesis
  • pathogenicity
  • secondary metabolites

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Published Papers (1 paper)

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Research

24 pages, 3919 KiB  
Article
A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis
by Yang Yang and Xuebo Hu
J. Fungi 2025, 11(1), 81; https://doi.org/10.3390/jof11010081 - 20 Jan 2025
Viewed by 429
Abstract
Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of T. versicolor using Illumina, PacBio HiFi, and Hi-C sequencing technologies. The assembled genome is 47.42 Mb in [...] Read more.
Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of T. versicolor using Illumina, PacBio HiFi, and Hi-C sequencing technologies. The assembled genome is 47.42 Mb in size and contains 13,307 protein-coding genes. BUSCO analysis revealed genome and gene completeness results of 95.80% and 95.90%, respectively. Phylogenetic analysis showed that T. versicolor is most closely related to T. pubescens, followed by T. cinnabarina and T. coccinea. Comparative genomic analysis identified 266 syntenic blocks between T. versicolor and Wolfiporia cocos, indicating a conserved evolutionary pattern between the two species. Gene family analysis highlighted the expansion and contraction of genes in functional categories related to the biosynthesis of secondary metabolites, including several T. versicolor-specific genes. Key genes involved in lignocellulose degradation and triterpene production were identified within the CAZyme and CYP450 gene families. Transcriptomic analysis under dark and light conditions revealed significant changes in the expression of genes related to secondary metabolism, suggesting that light signals regulate metabolic pathways. A total of 2577 transporter proteins and 2582 membrane proteins were identified and mapped in the T. versicolor genome, and 33 secondary metabolite gene clusters were identified, including two light-sensitive triterpene biosynthesis clusters. This study offers a comprehensive genomic resource for further investigation into the functional genomics, metabolic regulation, and triterpene biosynthesis of T. versicolor, providing valuable insights into fungal evolution and biotechnological applications. Full article
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