Diagnosis and Personalized Management of Endometriosis

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 4437

Special Issue Editors


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Guest Editor
1. Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2. Clinical Hospital of Obstetrics and Gynaecology “Prof. Dr. Panait Sârbu”, Bucharest, Romania
Interests: endometriosis; minimally invasive surgery (vaginal, laparoscopic and robotic surgery); urogynecology; gynecological oncology

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: endometriosis; infertility; hysteroscopy; laparoscopy; maternal fetal medicine
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Special Issue Information

Endometriosis is a chronic inflammatory disease that leads to pain and infertility, and occurs primarily in women of reproductive age. Endometriosis has a significant impact on women's health and health care costs. Endometriosis affects 6–10 ​% of reproductive-aged women and more than 175 million women worldwide. Most women with endometriosis suffer physically and emotionally in their day-to-day function as a result of these painful symptoms. Despite current research efforts, diagnosis and treatment options remain lacking. There remains doubt as to whether MRI is redundant and whether transvaginal ultrasound examination should be the only diagnostic method. The number of surgeries performed for endometriosis worldwide is ever increasing; thus, measuring the magnitude of the effect of surgery is of the utmost importance in order to define a therapeutic balance between benefits, harms and costs in various clinical conditions. We aim to present a selection of papers in this Special Issue that will focus on the optimum diagnostic techniques employed to treat this disease, as well as novel therapeutic approaches. We welcome you to submit original papers, reviews, and perspectives on the challenges present and information available with regard to cutting-edge endometriosis diagnosis and treatment.

Dr. Elvira Bratila
Dr. Claudia Mehedintu
Guest Editors

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Keywords

  • endometriosis
  • pain
  • infertility
  • minimally invasive surgery
  • ultrasound
  • MRI
  • medical treatment

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Published Papers (1 paper)

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Review

20 pages, 1920 KiB  
Review
Vitamin D—The Iceberg in Endometriosis—Review and Meta-Analysis
by Alexandra Ursache, Ludmila Lozneanu, Iuliana Elena Bujor, Cristina Elena Mandici, Lucian Vasile Boiculese, Alexandra Irma Gabriela Bausic, Mihaela Grigore, Demetra Socolov and Daniela Roxana Matasariu
J. Pers. Med. 2024, 14(1), 119; https://doi.org/10.3390/jpm14010119 - 20 Jan 2024
Cited by 4 | Viewed by 3919
Abstract
(1) Background: Although vitamin D has many known biological effects, very little research has been conducted on how vitamin D may be related or play a role in endometriosis. The aim of our study was to perform an evaluation regarding vitamin D levels [...] Read more.
(1) Background: Although vitamin D has many known biological effects, very little research has been conducted on how vitamin D may be related or play a role in endometriosis. The aim of our study was to perform an evaluation regarding vitamin D levels and possible implications in endometriosis through a statistical analysis of the data collected from the included studies. (2) Methods: For this review, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and PubMed/Internet portal of the National Library of Medicine databases using several keywords related to our topic. (3) Results: Only nine articles were identified as complete or possessing the capacity to compute all available data. We totalized a number of 976 patients with endometriosis and 674 controls. From the nine studies included in our analysis, three of them claim there is no difference between women with and without endometriosis concerning 25(OH) vitamin D levels; however, the other six studies found significant differences regarding this aspect. (4) Conclusions: Our results underscored the complexity of analyzing the role of the vitamin D complex in a challenging condition like endometriosis and suggest that focusing on the tissue level might be essential to obtain accurate answers to our inquiries. Full article
(This article belongs to the Special Issue Diagnosis and Personalized Management of Endometriosis)
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