Towards Precision Medicine in Parkinson’s Disease
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 25 June 2025 | Viewed by 1405
Special Issue Editor
Interests: deep brain stimulation; Parkinson’s disease; neurology and neurological rehabilitation; movement disorder
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Parkinson’s Disease (PD) is the second most common neurodegenerative condition characterized by multifaceted clinical presentation and disease course. Several motor and non-motor symptoms that can interplay, by defining for each single patient the specific clinical PD phenotype. Indeed, over the years, PD has been subdivided and phenotyped on the basis of motor and non-motor symptoms, and, more recently, on the basis of the hypothesized pathophysiological mechanisms (see, for example, the brain-first VS body-first classification). The main purpose of all these efforts for defining the different phenotypes of PD is to define the clinical and instrumental biomarkers of disease progression and response to dopaminergic drugs and advanced therapies (i.e., Deep Brain Stimulation, Levodopa–Carbidopa intestinal gel) in order to increasingly develop personalized medicine for PD patients. This also includes the recent discoveries that have made in the genetics of PD; thus, it is possible to also classify the disease on the basis of a specific genetic background. Based on these premises, the scope of this Special Issue encompasses various aspects of PD diagnosis and management with a focus on the classification of the different PD phenotypes and the identification of novel biomarkers that can allow to better define the progression of the disease and the response to treatments. By bringing together the latest research, clinical insights, and expert opinions, this Special Issue aims to provide a valuable resource for clinicians, researchers, and healthcare professionals involved in the diagnosis and management of PD. The collective knowledge presented here will contribute towards improved patient care and pave the way for future advancements in this field.
Dr. Francesco Cavallieri
Guest Editor
Manuscript Submission Information
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Keywords
- Parkinson’s disease
- Deep Brain Stimulation
- genetic
- GBA
- Levodopa–Carbidopa intestinal gel
- biomarkers
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